卫矛醇对C6胶质瘤细胞体外抗癌活性及机制探讨

目的:研究卫矛醇对C6胶质瘤细胞株的体外增殖及凋亡的影响。方法：将C6大鼠胶质瘤细胞随机分为对照组、卫矛醇干预组、卫矛醇+雷帕霉素组、卫矛醇+3-MA组,各组予不同药物孵育,采用MTT法检测卫矛醇对C6细胞的体外增殖抑制率,筛选出抑制率相对较高且生长状态良好的细胞;应用Hoechest 33342染色透射电镜观察细胞凋亡亚显微结构的改变,采用免疫荧光和Western Blot技术检测与凋亡和自噬相关蛋白的表达水平。结果:卫矛醇对C6胶质瘤细胞增殖有明显的抑制作用,并呈现出良好的浓度-效应相关性,与对照组比较,随着浓度的增加,细胞的增殖抑制率上升(P＜0.01);Hoechst染色结果显示,与对照组相比,共同孵育卫矛醇24 h后的C6细胞出现明显的核固缩现象,证明有大量的细胞出现凋亡;Western Blot结果显示,与对照组相比,促凋亡基因Bax表达上调,抗凋亡基因Bcl-2表达下调。结论:卫矛醇能够抑制C6细胞的增殖,并诱导其凋亡,其作用机制可能与上调Bax、下调Bcl-2有关。     

西藏自治区土壤侵蚀特点及现状

西藏自治区地域辽阔,土壤侵蚀复杂多样。本文在野外调查的基础上,对西藏自治区土壤侵蚀特点作了全面论述,并对西藏自治区不同类型土壤侵蚀区的土壤侵蚀现状做了较全面的分区评价。同时取雅江中游地区19个县作为典型区域,利用1999年1:20万TM遥感图像土壤侵蚀解译结果,对该典型区域的土壤侵蚀现状作了定量评价。最后根据评价结果,对西藏自治区土壤侵蚀的发展趋势做了预测。     

淇、卫河流域“96·8”致洪暴雨过程的数值模拟

应用LASGREMM模式 ,对淇、卫河流域“96·8”致洪暴雨过程进行了模拟预报分析。结果表明 ,LAS GREM模式不仅能较准确地预报淇、卫河流域暴雨落区 ,而且可以进一步分析天气过程的特点及演变情况     

2003年5月4日新疆伽师-岳普湖5.8级地震烈度分布及建筑物结构破坏特点

新疆伽师-岳普湖5．8级地震宏观震中位于岳普湖县的铁热木乡和兵团农三师42团的北面，震中烈度为Ⅶ度。本次地震影响范围位于巴楚-伽师6．8级地震Ⅵ-Ⅶ度影响区域内，累计破坏效应造成了较为严重的房屋破坏。通过对大量震害资料和强震记录的分析，根据建筑物的破坏情况和场地峰值加速度衰减特征，在尽可能排除累计破坏效应的基础上确定了地震烈度分布，分析了不同烈度区中的建筑物结构破坏特点及其与地震动影响场的关系。     

四川内江松柏寨旅游资源特征及开发浅论

详细介绍了内江松柏寨的七山、七堰、八景等自然景观；对以般若寺为代表的寺庙、寨门以及历代名人所留下的行踪和墨迹作了生动描写；提出以生态旅游为理念进行统一规划，并采取保护性开发的若干建议。     

Timing and geochemical characters of the Sanchazi magmatic arc in Mianlüe tectonic zone, South Qinling

The Sanchazi mafic-ultramafic complex in Mianlue tectonic zone, South Qinling can be subdivided into two blocks, i.e. Sanchazi paleo-magmatic arc and Zhuangkegou paleo-oceanic crust fragment (ophiolite). The Sanchazi paleo-magmatic arc is mainly composed of andesite, basaltic and basalt-andesitic gabbro (or diorite), andesitic dyke, plagiogranite and minor ultramafic rocks, which have typical geochemical features of island arc volcanic rocks, such as high field strength element (e.g. Nb, Ti) depletions and lower Cr, Ni contents. The Light rare earth element (LREE) and K enrichments of these rocks and zircon xenocrystals of 900 Ma from plagiogranite suggest that this magmatic arc was developed on the South active continental margin of the South Qinling micro-continent. The U-Pb age of (300 ± 61)Ma for zircons from plagiogranite indicates that the Mianlue paleo-oceanic crust was probably subducted underneath the South Qinling micro-continent in Carboniferous. This is consistent with the formation time (309Ma) of the Huwan eclogite originating from oceanic subduction in Dabie Mountains, suggesting that the Mianlue paleo-ocean probably extended eastward to the Dabie Mountains in Carboniferous. The high-Mg adakitic rocks in Sanchazi paleo-magmatic arc suggest that the subducted oceanic crust was relatively young (＜25Ma) and hot.     

Vicissitude of Sogo Nur and environmental-climatic change during last 1500 years

Lakes in arid zone are sensitive to climatic changes. The lacustrine sediment sequence in Sogo Nur has well and truly recorded climatic events such as the Sui-Tang Dynasty Warm Period, the Song-Liao Dynasty Cold Period, the Medieval Warm Period, the Little Ice Age and the 20th Century Warm Period. Commonly, the climate in warm Periods was relatively humid,accordingly the lake area extended and water level rose, and vice versa. Apart from climatic change, human activity is also an important factor of influencing lake vicissitude, and they played the dominant role alternatively during different periods; the factor of climatic change predominated in historical period, while since the beginning of the 20th century the utilization of water resources by human has became decisive.     

Study of charge structure and radiation characteristic of intracloud discharge in thunderstorms of Qinghai-Tibet Plateau

The comprehensive observations on lightning discharges were conducted in Naqu area of Qinghai-Tibet Plateau in summer of 2002. The electric structures of thunderstorms and the characteristics of lightning discharges at initial stage were analyzed by using the observation data. The results show that most of intracloud (IC) lightning flashes were polarities inverted in thunderstorms with tripole electric charge structure and occurred between negative charge region located in the middle of the thunderstorm and positive charge region located at the bottom of the thunderstorm. The radiation characteristics of discharge processes in cloud with longer lasting time involved in Cloud-to-Ground (CG) lightning flashes were similar to that of IC discharges.A lot of radiation pulses were produced in these discharge processes. Because the IC discharges took place at the bottom of thundercloud and were near the ground, they may produce more serious damage to equipment on the ground therefore should not be neglected in lightning protection.     

Sedimentary environment and development controls of the hydrocarbon source beds:Middle and Upper Proterozoic in northern North China

Problem on development control of marine source bed hold in Chinese petroleum industry progression. The Hongshuizhuang Formation,Tieling Formation and Xiamaling Formation in the Middle and Upper Proterozoic are important hydrocarbon source beds in northern North China, and investigation of their sedimentary environments and the controls has great significance for petroleum exploration in North China. Based on sedimentology (sequence stratigraphy), palaeoecology, sedimentary geochemistry, and sedimentary palaeogeography, their development pattern is discussed. All these studies indicate that the development controls of the hydrocarbon source beds include a favorite palaeogeographic location, exceeding propagation of biomes in low and middle latitudes, anoxic environments, enrichment of phosphorus element and the adsorption of clay minerals during the preservation of organic matter in the marine carbonates.     

重庆市地学旅游资源研究

重庆市的地学旅游资源极其丰富，可划分为岩石圈旅游资源等4个大类、地质旅游资源等11个基本类型、地层旅游景观等18种景观和黔江县上白垩统正阳组剖面等107个景区(景点)。它们具有类型齐全、分布广泛、岩溶精品和森林独特的特点。从加强岩溶旅游资源调查等6个方面入手，就可提高对它们的开发利用程度.