基于网络药理学与分子对接技术探讨青蛇方外用治疗湿疹的作用机制

目的：基于网络药理学与分子对接技术探讨青蛇方外用治疗湿疹的作用机制。方法：应用TCMSP和UniProt数据库平台查询青蛇方组方的有效活性成分及靶基因,与疾病靶基因取交集后构建蛋白质-蛋白质相互作用(PPI)网络;应用DAVID数据库,对潜在核心作用靶点基因进行基因本体（GO）功能、京都基因与基因组百科全书（KEGG）通路富集分析。利用分子对接原理论证青蛇方生物活性成分与核心靶点的分子结合能力。结果：筛选出青蛇方有效成分63种,作用靶点99个;主要有β-谷甾醇、2,4,7-三羟基-9,10-二氢菲、靛蓝素、豆甾醇、色氨酸等关键成分;转录因子AP-1（JUN）、肿瘤坏死因子（TNF）、原癌基因（RELA）、干扰素γ（IFNG）、转化生长因子-β1（TGF-β1）等核心基因。关键信号通路有癌症信号通路、恰加斯病通路、弓形体病通路、脂质和动脉粥样硬化通路等,分子对接结果显示活性成分与核心靶点基因结合能力较强。结论：青蛇方外用可以通过多种活性成分、多种通路有效抑制免疫炎症反应,促进免疫系统正常运行,从而达到治疗湿疹的目的。     

Diffuse band extinction and polarization in core-mantle grains

Diffuse band shapes in both extinction and polarization are calculated for interstellar coremantle particles for varying size distributions of mantle thickness. It is shown that no matter whether the source of the bands is in the silicate cores or the accreted icy mantles the polarization shapes are highly asymmetric for all mantel thicknesses. The extinction band shapes are significantly less asymmetric although the effect is clearly present. The only apparent possibility for producing symmetric band shapes in the dust grains is in the very small bare particles in interstellar space which, if they are aligned and produce the 2200 band, must exhibit a strong polarization effect in this region.Work supported in part by NASA Grant NGR-33-011-043.Paper presented at the Symposium on Solid State Astrophysics, held at the University College, Cardiff, Wales, between 9–12 July, 1974.     

基于“3N”理念的德化县旅游资源开发思路

现代社会的都市化及人工化,引发人类种种生理、心理问题,生活在钢筋水泥森林中的都市人逃出“现代围城”的欲望日益强烈,让身心回归真正的自然,于是“3N”旅游应运而生。本文结合德化县的实例,探讨“3N”旅游及其产品的开发问题。     

战略环境评价若干问题研究

分析了传统环境影响评价制度的不足，回顾了战略环境评价的研究与实践进展，阐述了战略环境评价与环境可持续发展的关系，并对以实现环境可持续发展为目标的战略环境评价体系所存在的问题进行了分析。     

淇、卫河流域“96·8”致洪暴雨过程的数值模拟

应用LASGREMM模式 ,对淇、卫河流域“96·8”致洪暴雨过程进行了模拟预报分析。结果表明 ,LAS GREM模式不仅能较准确地预报淇、卫河流域暴雨落区 ,而且可以进一步分析天气过程的特点及演变情况     

2003年5月4日新疆伽师-岳普湖5.8级地震烈度分布及建筑物结构破坏特点

新疆伽师-岳普湖5．8级地震宏观震中位于岳普湖县的铁热木乡和兵团农三师42团的北面，震中烈度为Ⅶ度。本次地震影响范围位于巴楚-伽师6．8级地震Ⅵ-Ⅶ度影响区域内，累计破坏效应造成了较为严重的房屋破坏。通过对大量震害资料和强震记录的分析，根据建筑物的破坏情况和场地峰值加速度衰减特征，在尽可能排除累计破坏效应的基础上确定了地震烈度分布，分析了不同烈度区中的建筑物结构破坏特点及其与地震动影响场的关系。     

静力弹塑性分析(Pushover Analysis)的基本原理和计算实例

阐述了美国两本手册FEMA273／274和ATC-40中关于静力弹塑性分析的基本原理和方法，给出了利用ETABS程序进行适合我国地震烈度分析的计算步骤，并用一框剪结构示例予以说明，表明Pushover方法是目前对结构进行在罕遇地震作用下弹塑性分析的有效方法。     

带"人字"支撑的新型复合结构体系动力特征研究

探讨了一种新型复合结构——带“人字”支撑的梁柱体系的动力特征问题。在满足静力荷载作用下承载力要求的基础上，根据结构动力学原理，推导了该结构体系的动力特征方程，分析了复合结构体系的支撑截面和型式的变化对动力特征的影响，计算显示，增加支撑对提高结构的频率即抗侧刚度有明显作用，且随支撑截面尺寸增大，固有频率单调增加。支撑倾角在一定范围内变化时，对频率影响较大，而超过该范围时，其影响明显减小，由此说明“人字”支撑为较合理的支撑型式。结果表明，所研究的具有“人字”支撑的复合结构体系具有较高的抗侧能力。     

Typical basin-fill sequences and basin migration in Yanshan, North China--Response to Mesozoic tectonic transition

Basin-fill sequences of Mesozoic typical basins in the Yanshan area, North China may be divided into four phases, reflecting lithosphere tectonic evolution from flexure (T3), flexure with weak rifting (J1+2), tectonic transition (J3), and rifting (K). Except the first phase, the other three phases all start with lava and volcaniclastic rocks, and end with thick coarse clastic rocks and/or conglomerates, showing cyclic basin development rather than simple cyclic rift mechanism and disciplinary basin-stress change from extension to compression in each phase. Prototype basin analysis, based on basin-fill sequences, paleocurrent distribution and depositional systems, shows that single basin-strike and structural-line direction controlling basin development had evidently changed from east-west to northeast in Late Jurassic in the Yanshan area, although basin group still occurred in east-west zonal distribution. Till Early Cretaceous, main structural-line strike controlling basins just turned to northeast by north in the studied area.     

Vicissitude of Sogo Nur and environmental-climatic change during last 1500 years

Lakes in arid zone are sensitive to climatic changes. The lacustrine sediment sequence in Sogo Nur has well and truly recorded climatic events such as the Sui-Tang Dynasty Warm Period, the Song-Liao Dynasty Cold Period, the Medieval Warm Period, the Little Ice Age and the 20th Century Warm Period. Commonly, the climate in warm Periods was relatively humid,accordingly the lake area extended and water level rose, and vice versa. Apart from climatic change, human activity is also an important factor of influencing lake vicissitude, and they played the dominant role alternatively during different periods; the factor of climatic change predominated in historical period, while since the beginning of the 20th century the utilization of water resources by human has became decisive.