A MESO-β SCALE SIMULATION OF THE EFFECTS OF BOREAL FOREST ECOSYSTEM ON THE LOWER ATMOSPHERE

Based on the Intensive Field Campaign(IFC-1)data of Boreal Ecosystem-Atmosphere Study(BOREAS).a three-dimensional meso-β scale model is used to simulate the effect of boreal forests onthe lower atmosphere.A fine horizontal resolution of 2 km×2 km is used in order to distinguish thevegetative heterogeneity in the boreal region.A total of 20×25 grid points cover the entire sub-modeling area in BOREAS' South Study Area(SSA).The ecosystem types and their coverage ineach grid square are extracted from the North American Land Cover Characteristics Data Base(NALCCD)generated by the U.S.Geographical Survey(USGS)and the University of Nebraska-Lincoln(UNL).The topography of the study area is taken from the Digital Elevation Map(DEM)of USGS.The model outputs include the components of the energy balance budget within the canopyand at the ground.the turbulence parameters in the atmospheric boundary layer and the wind.temperature and humidity profiles extending up to a height of 1500 m.In addition to the fine timeand spatial step,the unique feature of the present model is the incorporation of both dynamic andbiological effects of the Boreal forest into the model parameterization scheme.The model resultscompare favorably with BOREAS' IFC-1 data in 1994 when the forest was in the luxuriant growingperiod.     

基于网络药理学探究补阳还五汤治疗颈椎病的作用机制

目的：基于网络药理学与分子对接技术分析补阳还五汤治疗颈椎病的作用机制。方法：使用TCMSP、化学专业数据库获取补阳还五汤的活性成分,并对潜在靶点进行预测及规范。分别从PharmGKB、DisGeNET、OMIM、GeneCards数据库中得到颈椎病疾病靶点,利用韦恩图获取补阳还五汤与颈椎病的交集靶点。通过CytoScape软件构建中药-活性成分-疾病靶点和蛋白质-蛋白质相互作用（PPI）网络,获得核心有效成分与关键靶点,利用David数据库对潜在靶点进行富集分析。最后运用AutoDock Vina软件对补阳还五汤核心有效成分与关键靶点进行分子对接验证。结果：共获得补阳还五汤治疗颈椎病的有效活性成分97个,包括槲皮素、山柰酚、黄芩素、木犀草素等;交集靶点64个,关键靶点有白细胞介素-6（IL-6）、肿瘤坏死因子（TNF）、丝氨酸/苏氨酸蛋白激酶1（AKT1）、白细胞介素-1B（IL-1B）等;主要涉及肿瘤坏死因子（TNF）、白细胞介素-17（IL-17）、磷脂酰肌醇3-激酶（PI3K）/蛋白激酶B（Akt）等信号通路,分子对接结果显示核心有效成分与关键靶点之间结合紧密,为补阳还五汤治疗颈椎病提供相应条件。结论：该研究在总体上预测了补阳还五汤治疗颈椎病的活性成分、靶点和信号通路,作用途径广泛,为下一步的临床应用提供参考及思路。     

Freshening of the Intermediate Waters in the Northern South China Sea over the PastSix Decades

The properties of salinity in the South China Sea (SCS), a significant marginal sea connecting the Pacific andIndian Oceans, are greatly influenced by the transport of fresh water flux between the two oceans. However, the long-termchanges in the intermediate water in the SCS have not been thoroughly studied due to limited data, particularly in relationto its thermodynamic variations. This study utilized reanalysis data products to identify a 60-year trend of freshening in theintermediate waters of the northern South China Sea (NSCS), accompanied by an expansion of low-salinity water. Thestudy also constructed salinity budget terms, including advection and entrainment processes, and conducted an analysis ofthe salinity budget to understand the impacts of external and internal dynamic processes on the freshening trend of theintermediate water in the NSCS. The analysis revealed that the freshening in the northwest Pacific Ocean and theintensification of intrusion through the Luzon Strait at intermediate levels are the primary drivers of the salinity changes inthe NSCS. Additionally, a weakened trend in the intensity of vertical entrainment also contributes to the freshening in theNSCS. This study offers new insights into the understanding of regional deep sea changes in response to variations in boththermodynamics and oceanic dynamic processes.     

基于数据挖掘探析张奇文治疗癫痫的用药规

目的：基于数据挖掘技术探析全国名中医张奇文治疗癫痫的用药规律。方法：收集1998年9月1日至2019年9月30日张奇文治疗癫痫的医案,对医案中的数据进行规范化处理,构建数据库,应用古今医案云平台V2.3.5对中药使用频次、四气五味、功效归经、关联、聚类等进行分析,并总结临床经验。结果：共筛选出40首处方,中药120味。排前10位的中药分别为全蝎、蜈蚣、僵蚕、炙甘草、麦芽、山楂、钩藤、羚羊角、珍珠、牛黄,药性以平、温为主,药味主要为甘、辛、苦,主要归肝、肺、脾经,功效以通络止痛、攻毒散结、息风镇痉等为主。关联组合支持度高的组合为全蝎-蜈蚣、全蝎-僵蚕、僵蚕-蜈蚣、钩藤-全蝎、钩藤-蜈蚣。结论：张奇文治疗癫痫标本兼顾,治标重视息风,治本重视健脾。     

基于网络药理学与分子对接技术探讨青蛇方外用治疗湿疹的作用机制

目的：基于网络药理学与分子对接技术探讨青蛇方外用治疗湿疹的作用机制。方法：应用TCMSP和UniProt数据库平台查询青蛇方组方的有效活性成分及靶基因,与疾病靶基因取交集后构建蛋白质-蛋白质相互作用(PPI)网络;应用DAVID数据库,对潜在核心作用靶点基因进行基因本体（GO）功能、京都基因与基因组百科全书（KEGG）通路富集分析。利用分子对接原理论证青蛇方生物活性成分与核心靶点的分子结合能力。结果：筛选出青蛇方有效成分63种,作用靶点99个;主要有β-谷甾醇、2,4,7-三羟基-9,10-二氢菲、靛蓝素、豆甾醇、色氨酸等关键成分;转录因子AP-1（JUN）、肿瘤坏死因子（TNF）、原癌基因（RELA）、干扰素γ（IFNG）、转化生长因子-β1（TGF-β1）等核心基因。关键信号通路有癌症信号通路、恰加斯病通路、弓形体病通路、脂质和动脉粥样硬化通路等,分子对接结果显示活性成分与核心靶点基因结合能力较强。结论：青蛇方外用可以通过多种活性成分、多种通路有效抑制免疫炎症反应,促进免疫系统正常运行,从而达到治疗湿疹的目的。     

淇、卫河流域“96·8”致洪暴雨过程的数值模拟

应用LASGREMM模式 ,对淇、卫河流域“96·8”致洪暴雨过程进行了模拟预报分析。结果表明 ,LAS GREM模式不仅能较准确地预报淇、卫河流域暴雨落区 ,而且可以进一步分析天气过程的特点及演变情况     

Typical basin-fill sequences and basin migration in Yanshan, North China--Response to Mesozoic tectonic transition

Basin-fill sequences of Mesozoic typical basins in the Yanshan area, North China may be divided into four phases, reflecting lithosphere tectonic evolution from flexure (T3), flexure with weak rifting (J1+2), tectonic transition (J3), and rifting (K). Except the first phase, the other three phases all start with lava and volcaniclastic rocks, and end with thick coarse clastic rocks and/or conglomerates, showing cyclic basin development rather than simple cyclic rift mechanism and disciplinary basin-stress change from extension to compression in each phase. Prototype basin analysis, based on basin-fill sequences, paleocurrent distribution and depositional systems, shows that single basin-strike and structural-line direction controlling basin development had evidently changed from east-west to northeast in Late Jurassic in the Yanshan area, although basin group still occurred in east-west zonal distribution. Till Early Cretaceous, main structural-line strike controlling basins just turned to northeast by north in the studied area.     

Structural features and petroleum geology of the fold-thrust belt in the southern Tarim basin, China

The west Kunlun fold-thrust belt (WKFTB) and the Altun fold-thrust belt (AFTB) are respectively located in the southern margin of the Tarim basin, NW China. The analyses of typical structures and regional dynamics of the fold-thrust belts reveal their different structural and petroleum features and mechanisms. WKFTB differs from AFTB by abundant fault-related folds and triangles zones, and was formed by northward extrusion of the west Kunlun orogen. AFTB was affected synchronously by northward extrusion of the Altun orogen and the sinistral strike-slipping of the Altun Fault, so it is characterized by the minor scale and the monotonous structural styles. The Aqike anticline and the Aqike fault, of which the strikes are orthogonal to the strike of the fold-thrust belts, are regarded as the adjustive structures between both of the fold-thrust belts. The oil-gas pools of WKFTB develop mainly in the faulted-related anticline traps, but the oil-gas pools of AFTB develop mainly in the low fault-block and anticlines traps related with the paleo-uplifts. There are different exploration countermeasures for both of the fold-thrust belts.     

Development of joints and shear fractures in the Kuqa depression and its implication to regional stress field switching

The superimposed basin must have undergone the changes of regional stress field. Study on the nature and switch of regional stress field of superimposed basin is very useful to understanding its stress state and tectonic events during its formation and evolution. As sensitive markers of small stress changes, joint and shear fracture, characterized by consistency of orientation over wide area, can be used to reconstruct paleostress state and its evolution. Detailed observations and analysis on the orientations, geometrical patterns, sequences of joints and shear fractures and their chronological relation to faults and folds show that, the NEE-SWW systematic joints and NNW-SSE systematic joints developed in the Mesozoic and Cenozoic strata are much more prominent than NW-SE systematic joints and shear fractures with different orientations. And the NWW-SEE and NW-SE systematic joints formed later than NEE-SWW systematic joints but earlier than shear fractures with different orientations. According to the relationships between joint and shear fractures and stress, the NEE-SWW systematic joints are inferred to result from lateral weak extension caused by the late Cretaceous regional uplift, while the NNW-SSE and NW-SE systematic joints are interpreted as syn-tectonic deformation relating to strong N-S compression in the Neogene. But some conjugate shear fractures occur probably due to sinistral strike-slip faulting in the Kuqa depression. At the beginning of the Neogene, the stress field changed and the maximal principal stress σ1 switched from vertical to horizontal.