基于网络药理学探究补阳还五汤治疗颈椎病的作用机制

目的：基于网络药理学与分子对接技术分析补阳还五汤治疗颈椎病的作用机制。方法：使用TCMSP、化学专业数据库获取补阳还五汤的活性成分,并对潜在靶点进行预测及规范。分别从PharmGKB、DisGeNET、OMIM、GeneCards数据库中得到颈椎病疾病靶点,利用韦恩图获取补阳还五汤与颈椎病的交集靶点。通过CytoScape软件构建中药-活性成分-疾病靶点和蛋白质-蛋白质相互作用（PPI）网络,获得核心有效成分与关键靶点,利用David数据库对潜在靶点进行富集分析。最后运用AutoDock Vina软件对补阳还五汤核心有效成分与关键靶点进行分子对接验证。结果：共获得补阳还五汤治疗颈椎病的有效活性成分97个,包括槲皮素、山柰酚、黄芩素、木犀草素等;交集靶点64个,关键靶点有白细胞介素-6（IL-6）、肿瘤坏死因子（TNF）、丝氨酸/苏氨酸蛋白激酶1（AKT1）、白细胞介素-1B（IL-1B）等;主要涉及肿瘤坏死因子（TNF）、白细胞介素-17（IL-17）、磷脂酰肌醇3-激酶（PI3K）/蛋白激酶B（Akt）等信号通路,分子对接结果显示核心有效成分与关键靶点之间结合紧密,为补阳还五汤治疗颈椎病提供相应条件。结论：该研究在总体上预测了补阳还五汤治疗颈椎病的活性成分、靶点和信号通路,作用途径广泛,为下一步的临床应用提供参考及思路。     

2003年6月青岛崂山4级震群序列初步分析

从震群监测、地震影响、地震地质构造、序列特点及性质判定等方面对2003年6月青岛崂山王哥庄发生的4级震群进行了介绍及初步分析。此次地震的活动强度、频次、持续时间均为青岛历史上所罕见。地震时整个青岛市普遍有感，震中区有一定破坏，造成较大的社会影响。     

Timing and geochemical characters of the Sanchazi magmatic arc in Mianlüe tectonic zone, South Qinling

The Sanchazi mafic-ultramafic complex in Mianlue tectonic zone, South Qinling can be subdivided into two blocks, i.e. Sanchazi paleo-magmatic arc and Zhuangkegou paleo-oceanic crust fragment (ophiolite). The Sanchazi paleo-magmatic arc is mainly composed of andesite, basaltic and basalt-andesitic gabbro (or diorite), andesitic dyke, plagiogranite and minor ultramafic rocks, which have typical geochemical features of island arc volcanic rocks, such as high field strength element (e.g. Nb, Ti) depletions and lower Cr, Ni contents. The Light rare earth element (LREE) and K enrichments of these rocks and zircon xenocrystals of 900 Ma from plagiogranite suggest that this magmatic arc was developed on the South active continental margin of the South Qinling micro-continent. The U-Pb age of (300 ± 61)Ma for zircons from plagiogranite indicates that the Mianlue paleo-oceanic crust was probably subducted underneath the South Qinling micro-continent in Carboniferous. This is consistent with the formation time (309Ma) of the Huwan eclogite originating from oceanic subduction in Dabie Mountains, suggesting that the Mianlue paleo-ocean probably extended eastward to the Dabie Mountains in Carboniferous. The high-Mg adakitic rocks in Sanchazi paleo-magmatic arc suggest that the subducted oceanic crust was relatively young (＜25Ma) and hot.     

The diurnal and seasonal characteristics of urban heat island variation in Beijing city and surrounding areas and impact factors based on remote sensing satellite data

Based on the land surface temperature (LST), the land cover classification map,vegetation coverage, and surface evapotranspiration derived from EOS-MODIS satellite data, and by the use of GIS spatial analytic technique and multivariate statistical analysis method, the urban heat island (UHI) spatial distribution of the diurnal and seasonal variabilities and its driving forces are studied in Beijing city and surrounding areas in 2001. The relationships among UHI distribution and landcover categories, topographic factor, vegetation greenness, and surface evapotranspiration are analyzed. The results indicate that: (i) The significant UHI occur in Beijing city areas in the four seasons due to high heat capacity and multi-reflection of compression building, as well as with special topographic features of its three sides surrounded by mountains,especially in the summer. The UHI spatial distribution is corresponding with the urban geometry structure profile. The LST difference is approximately 4-6℃ between Beijing city and suburb areas, comparatively is 8- 10℃ between Beijing city area and outer suburb area in northwestern regions. (ii) The UHI distribution and intensity in daytime are different from nighttime in Beijing city area, the nighttime UHI is obvious. However, in the daytime, the significant UHI mainly appears in the summer, the autumn takes second place, and the UHI in the winter and the spring seem not obvious. The surface evapotranspiration in suburb areas is larger than that in urban areas in the summer, and high latent heat exchange is evident, which leads to LST difference between city area and suburb area. (iii) The reflection of surface landcover categories is sensitive to the UHI, the correlation between vegetation greenness and UHI shows obviously negative.The scatterplot shows that there is the negative correlation between NDVI and LST (R2 = 0.6481).The results demonstrate that the vegetation greenness is an important factor for reducing the UHI,and large-scale construction of greenbelts can considerably reduce the UHI effect.     

Post-depositional modification of NO-3 in snow layers at EastAntarctica and at the headwater of ürumqi River

Acidic species, such as Nitrate, in polar snow and firn layers are “reversibly” deposited, and are sufficiently volatile to undergo significant postdepositional exchange between snow/firn and the atmosphere. Through comparison of the snowpit and snowpack nitrate concentrations from central East Antarctica and the headwater of ürumqi River, we conclude that the nitrate peaks in the uppermost surface snow layers in central Antarctica are not related to an atmospheric signal and must account for post-depositional effects. Such effects, however, are not found in the surface snowpack nitrate profiles from the headwater of ürumqi River. Two reasons may account for the post-depositional difference. At first, nitrate in the polar snow and firn layers appears to be hydrated ion, which can be taken up by the atmosphere, while at the headwater of ürumqi River it seems mainly as mineral ion, which assembles the behavior of aerosol-derived species that are “irreversibly” deposited and do not undergo significant post-depositional exchange with the atmosphere. Secondly, the chemical features of the snow and ice on the Antarctica are mainly determined by wet deposition, to the contrary, dry deposition is more significant at the headwater of lUrumqi River than that on the East Antarctic Plateau.     

季节内印度洋-西太平洋对流涛动对次季节-季节尺度大气可预报性的影响

利用非线性局部Lyapunov指数和条件非线性局部Lyapunov指数定量估计了季节内印度洋-西太平洋对流涛动（IPCO）和实时多变量Madden-Julian指数（RMM指数）可预报期限,量化了季节内IPCO对S2S尺度大气可预报性的贡献,深入研究了季节内IPCO演变下S2S尺度可预报期限空间分布的变化规律。结果表明：（1）与RMM指数相比,季节内IPCO指数可预报性更强,可预报期限达到31天左右,比RMM指数高出2周以上;（2）印度洋-西太平洋区域S2S尺度大气可预报性最强,可预报期限达到30天以上,其中季节内IPCO是该地区的主要可预报性来源之一,其贡献达到6天,占总可预报期限的25%以上;（3）随着季节内IPCO的演变,印度洋-西太平洋地区S2S尺度大气可预报性有空间结构变化,表现为可预报期限异常的传播和振荡。S2S尺度大气可预报期限正负异常沿季节内IPCO传播路径,一支以赤道中西印度洋为起点北传至印度半岛,一支向东传播,经过海洋性大陆到赤道西太平洋后向北传播,到达日本南部。同时,可预报性异常的传播在在东印度洋和西太平洋表现出反向变化的特征,形成东西两极振荡,当季节内IPCO向正位相发展时,东印度洋具有更强的可预报性,西太平洋具有更弱的可预报性,反之亦然。季节内IPCO的发展（衰退）可使东印度洋（西太平洋）S2S尺度大气可预报性更强,表明模式预报技巧对此具有更大的提升空间。     

青藏高原东部表层土壤色度的空间变化特征及其环境意义

认识青藏高原东部现代表土的色度特征及其空间分布,理解其与现代气候因子之间的联系,对于高原地区黄土-古环境重建和揭示第四纪环境变化历史具有重要意义。通过对研究区表层土壤色度的详细分析,对比现代气候资料,探讨了青藏高原东部表层土壤色度的空间变化特征及其环境意义。结果表明：① 高原东部表土色度参数空间变化特征差异显著,表现为随纬度升高,土壤亮度呈先减小后增大的趋势,而红度和黄度则逐步减小;随经度的升高,黄度先增大后减小,而红度值逐步减小;红度和黄度整体随着海拔上升而呈先减小后升高的特征。这些变化特征和差异是表土色度对高原东部复杂地理环境和水热条件变化响应的结果。② 在高原的干旱-半湿润区,土壤亮度对降水的响应敏感;红度和黄度对大尺度的温度变化响应较敏感,而较冷的环境下,红度对温度响应复杂,但与降水存在一定的联系。红度/黄度比值主要指示了气候控制下的赤铁矿和针铁矿的变化和竞争,对干旱-半湿润区域的降水变化响应较为敏感。青藏高原东部现代表土色度与气候密切相关,其空间变化特征一定程度上反映了该地区现代气候因子的空间变化;另一方面由于该区地形和气候复杂多变,部分色度指标与气候关系复杂,在重建青藏高原东部黄土古环境变化历史时需要谨慎。     

基于球面QTM的大范围有源淹没算法研究

面对海平面上升后沿海区域大范围淹没模拟的应用需求,提出了一种基于球面QTM的大范围有源淹没算法,首先构建了研究区域的QTM三角格网集,并利用海陆分离的思想确定了初始淹没单元;然后基于QTM的12邻近搜索设计了面向多目标三角格网的淹没范围扩张方法,将初始淹没单元递归扩张得到最终的淹没范围;最后应用Visual C#语言及Microsoft DirectX三维图形接口设计开发了相应的试验原型系统,并利用天地图高分辨率影像和SRTM地形数据对试验区域进行了海平面上升后的大范围淹没模拟试验。结果表明,该算法具有较好的实用性,可以有效地对海平面上升后的大区域范围进行动态地淹没模拟,对辅助防灾减灾具有一定意义。     

基于奇异值分解的遥感图像鲁棒水印算法探讨

针对遥感图像的安全保护问题,文章提出了一种基于DCT-SVD和最近区间量化的鲁棒水印算法,将遥感图像进行分块,选择视觉掩蔽效应好的纹理子块作为嵌入区域,根据混合变换后的系数在各自所属区间上的位置,将系数进行最近区间量化来嵌入水印信息;利用密钥即可实现水印的提取,不需要原始遥感图像参与。实验结果表明,该算法对加噪、滤波、旋转、缩放、随机剪切、JPEG压缩等攻击均具有较强的鲁棒性,可有效保护遥感图像的安全。     

基于遥感和GIS技术的漓江自然地貌破坏现状调查

针对漓江流域自然地貌被人为破坏的现状,以0.61 m分辨率的QuickBird 2和5.6m分辨率的IRS-P6卫星遥感数据为信息源,在ENVI和MapGIS软件的支持下,对漓江流经桂林市区段,即兰洲大桥—磨盘山大桥之间约30 km河岸自然地貌遭受人为破坏的现状开展了遥感调查.通过遥感图像处理、分析和人机交互解译,对3种河岸地类(农林用地、建筑用地和自然景观区用地)进行了测量与统计分析,结果表明:2009年漓江两岸农林用地占岸长度为河岸总长度的57.78％,建筑用地占35.95％,自然景观用地仅占6.27％.这说明,随着桂林城市规模的急速扩展,人类活动对漓江自然地貌形态造成了严重破坏,漓江综合治理已经刻不容缓.