基于网络药理学与分子对接技术探讨青蛇方外用治疗湿疹的作用机制

目的：基于网络药理学与分子对接技术探讨青蛇方外用治疗湿疹的作用机制。方法：应用TCMSP和UniProt数据库平台查询青蛇方组方的有效活性成分及靶基因,与疾病靶基因取交集后构建蛋白质-蛋白质相互作用(PPI)网络;应用DAVID数据库,对潜在核心作用靶点基因进行基因本体（GO）功能、京都基因与基因组百科全书（KEGG）通路富集分析。利用分子对接原理论证青蛇方生物活性成分与核心靶点的分子结合能力。结果：筛选出青蛇方有效成分63种,作用靶点99个;主要有β-谷甾醇、2,4,7-三羟基-9,10-二氢菲、靛蓝素、豆甾醇、色氨酸等关键成分;转录因子AP-1（JUN）、肿瘤坏死因子（TNF）、原癌基因（RELA）、干扰素γ（IFNG）、转化生长因子-β1（TGF-β1）等核心基因。关键信号通路有癌症信号通路、恰加斯病通路、弓形体病通路、脂质和动脉粥样硬化通路等,分子对接结果显示活性成分与核心靶点基因结合能力较强。结论：青蛇方外用可以通过多种活性成分、多种通路有效抑制免疫炎症反应,促进免疫系统正常运行,从而达到治疗湿疹的目的。     

淇、卫河流域“96·8”致洪暴雨过程的数值模拟

应用LASGREMM模式 ,对淇、卫河流域“96·8”致洪暴雨过程进行了模拟预报分析。结果表明 ,LAS GREM模式不仅能较准确地预报淇、卫河流域暴雨落区 ,而且可以进一步分析天气过程的特点及演变情况     

2003年5月4日新疆伽师-岳普湖5.8级地震烈度分布及建筑物结构破坏特点

新疆伽师-岳普湖5．8级地震宏观震中位于岳普湖县的铁热木乡和兵团农三师42团的北面，震中烈度为Ⅶ度。本次地震影响范围位于巴楚-伽师6．8级地震Ⅵ-Ⅶ度影响区域内，累计破坏效应造成了较为严重的房屋破坏。通过对大量震害资料和强震记录的分析，根据建筑物的破坏情况和场地峰值加速度衰减特征，在尽可能排除累计破坏效应的基础上确定了地震烈度分布，分析了不同烈度区中的建筑物结构破坏特点及其与地震动影响场的关系。     

静力弹塑性分析(Pushover Analysis)的基本原理和计算实例

阐述了美国两本手册FEMA273／274和ATC-40中关于静力弹塑性分析的基本原理和方法，给出了利用ETABS程序进行适合我国地震烈度分析的计算步骤，并用一框剪结构示例予以说明，表明Pushover方法是目前对结构进行在罕遇地震作用下弹塑性分析的有效方法。     

带"人字"支撑的新型复合结构体系动力特征研究

探讨了一种新型复合结构——带“人字”支撑的梁柱体系的动力特征问题。在满足静力荷载作用下承载力要求的基础上，根据结构动力学原理，推导了该结构体系的动力特征方程，分析了复合结构体系的支撑截面和型式的变化对动力特征的影响，计算显示，增加支撑对提高结构的频率即抗侧刚度有明显作用，且随支撑截面尺寸增大，固有频率单调增加。支撑倾角在一定范围内变化时，对频率影响较大，而超过该范围时，其影响明显减小，由此说明“人字”支撑为较合理的支撑型式。结果表明，所研究的具有“人字”支撑的复合结构体系具有较高的抗侧能力。     

Typical basin-fill sequences and basin migration in Yanshan, North China--Response to Mesozoic tectonic transition

Basin-fill sequences of Mesozoic typical basins in the Yanshan area, North China may be divided into four phases, reflecting lithosphere tectonic evolution from flexure (T3), flexure with weak rifting (J1+2), tectonic transition (J3), and rifting (K). Except the first phase, the other three phases all start with lava and volcaniclastic rocks, and end with thick coarse clastic rocks and/or conglomerates, showing cyclic basin development rather than simple cyclic rift mechanism and disciplinary basin-stress change from extension to compression in each phase. Prototype basin analysis, based on basin-fill sequences, paleocurrent distribution and depositional systems, shows that single basin-strike and structural-line direction controlling basin development had evidently changed from east-west to northeast in Late Jurassic in the Yanshan area, although basin group still occurred in east-west zonal distribution. Till Early Cretaceous, main structural-line strike controlling basins just turned to northeast by north in the studied area.     

Structural features and petroleum geology of the fold-thrust belt in the southern Tarim basin, China

The west Kunlun fold-thrust belt (WKFTB) and the Altun fold-thrust belt (AFTB) are respectively located in the southern margin of the Tarim basin, NW China. The analyses of typical structures and regional dynamics of the fold-thrust belts reveal their different structural and petroleum features and mechanisms. WKFTB differs from AFTB by abundant fault-related folds and triangles zones, and was formed by northward extrusion of the west Kunlun orogen. AFTB was affected synchronously by northward extrusion of the Altun orogen and the sinistral strike-slipping of the Altun Fault, so it is characterized by the minor scale and the monotonous structural styles. The Aqike anticline and the Aqike fault, of which the strikes are orthogonal to the strike of the fold-thrust belts, are regarded as the adjustive structures between both of the fold-thrust belts. The oil-gas pools of WKFTB develop mainly in the faulted-related anticline traps, but the oil-gas pools of AFTB develop mainly in the low fault-block and anticlines traps related with the paleo-uplifts. There are different exploration countermeasures for both of the fold-thrust belts.     

Development of joints and shear fractures in the Kuqa depression and its implication to regional stress field switching

The superimposed basin must have undergone the changes of regional stress field. Study on the nature and switch of regional stress field of superimposed basin is very useful to understanding its stress state and tectonic events during its formation and evolution. As sensitive markers of small stress changes, joint and shear fracture, characterized by consistency of orientation over wide area, can be used to reconstruct paleostress state and its evolution. Detailed observations and analysis on the orientations, geometrical patterns, sequences of joints and shear fractures and their chronological relation to faults and folds show that, the NEE-SWW systematic joints and NNW-SSE systematic joints developed in the Mesozoic and Cenozoic strata are much more prominent than NW-SE systematic joints and shear fractures with different orientations. And the NWW-SEE and NW-SE systematic joints formed later than NEE-SWW systematic joints but earlier than shear fractures with different orientations. According to the relationships between joint and shear fractures and stress, the NEE-SWW systematic joints are inferred to result from lateral weak extension caused by the late Cretaceous regional uplift, while the NNW-SSE and NW-SE systematic joints are interpreted as syn-tectonic deformation relating to strong N-S compression in the Neogene. But some conjugate shear fractures occur probably due to sinistral strike-slip faulting in the Kuqa depression. At the beginning of the Neogene, the stress field changed and the maximal principal stress σ1 switched from vertical to horizontal.     

GPS水汽遥感中的大气干延迟局地订正模型研究

在GPS遥感水汽过程中,大气干延迟模型的精度直接影响水汽遥感的精度。根据广东清远站1995～2001年的气象探空资料,计算了GPS水汽测量中的实际大气干延迟。在此资料基础上,利用地面气象要素建立了大气干延迟的年和分月局地订正模型。分析结果表明,年模型的精度优于目前广泛使用的普适模型;月模型与年模型相比,效果不是很明显,建立局地分月订正模型意义不大;在对高度角的敏感程度上,局地模型略大些;当高度角小于75时,大气干延迟弯曲路径与直线路径之差ΔS随天顶角增大而迅速增大。     

从安徽气候变化看2003年洪涝和高温的必然性

利用近 50年温度和降水资料研究了安徽夏季气候变化特征 ,解释了 2 0 0 3年夏季洪涝、高温等极端气候事件出现的必然性。研究结果表明 :(1 )近 50年来安徽夏季温度呈下降趋势 ,降水则呈增加趋势 ,两者变化是相协调的。目前夏季温度处于较低的气候基本态 ,降水处于高基本态。 (2 )无论是温度还是降水 ,其变率都在 2 0世纪80年代中后期开始上升 ,目前均处于高气候变率时期。降水的“两高”(高基本态和高气候变率 )结合决定了 2 0 0 3年夏季洪涝出现的必然性 ;温度的较低基本态决定了“凉夏”背景 ,但由于基本态的回升和变率的加大 ,仍会出现像 2 0 0 3年夏季的若干高温天气。 (3)最大熵谱估计表明 ,安徽夏季降水变化的主周期为 2 5年 ,反映了降水的准两年振荡特征