Finite element formulation and algorithms for unsaturated soils. Part II: Verification and application

The finite‐element formulation and integration algorithms developed in Part I are used to analyse a number of practical problems involving unsaturated and saturated soils. The formulation and algorithms perform well for all the cases analysed, with the robustness of the latter being largely insensitive to user‐defined parameters such as the number of coarse time steps and error control tolerances. The efficiency of the algorithms, as measured by the CPU time consumed, does not depend on the number of coarse time steps, but may be influenced by the error control tolerances. Based on the analyses presented here, typical values for the error control tolerances are suggested. It is also shown that the constitutive modelling framework presented in Part I can, by adjusting one constitutive equation and one or two material parameters, be used to simulate soils that expand or collapse upon wetting. Treating the suction as a strain variable instead of a stress variable proves to be an efficient and robust way of solving suction‐dependent plastic yielding. Moreover, the concept of the constitutive stress is a particularly convenient way of handling the transition between saturation and unsaturation. Copyright © 2003 John Wiley & Sons, Ltd.     

Effect of spatial variation characteristics on contouring of design storm depth

The ordinary kriging method, a geostatistical interpolation technique, was applied for developing contour maps of design storm depth in northern Taiwan using intensity–duration–frequency (IDF) data. Results of variogram modelling on design storm depths indicate that the design storms can be categorized into two distinct storm types: (i) storms of short duration and high spatial variation and (ii) storms of long duration and less spatial variation. For storms of the first category, the influence range of rainfall depth decreases when the recurrence interval increases, owing to the increasing degree of their spatial independence. However, for storms of the second category, the influence range of rainfall depth does not change significantly and has an average of approximately 72 km. For very extreme events, such as events of short duration and long recurrence interval, we do not recommend usage of the established design storm contours, because most of the interstation distances exceed the influence ranges. Our study concludes that the influence range of the design storm depth is dependent on the design duration and recurrence interval and is a key factor in developing design storm contours. Copyright © 2003 John Wiley & Sons, Ltd.     

Uncoupling of coupled flows in soil—a finite element method

Coupled flow of water, chemicals, heat and electrical potential in soil are of significance in a variety of circumstances. The problem is characterized by the coupling between different flows, i.e. a flow of one type driven by gradients of other types, and by the dual nature of certain flows, i.e. combined convection and conduction. Effective numerical solutions to the problem are challenged due to the coupling and the dual nature. In this paper, we first present a general expression that can be used to represent various types of coupled flows in soil. A finite element method is then proposed to solve the generalized coupled flows of convection-conduction pattern. The unknown vector is first decomposed into two parts, a convective part forming a hyperbolic system and a conductive part forming a parabolic system. At each time step, the hyperbolic system is solved analytically to give an initial solution. To solve the multi-dimensional hyperbolic system, we assume that a common eigenspace exists for the coefficient matrices, so that the system can be uncoupled by transforming the unknown vector to the common eigenspace. The uncoupled system is solved by the method of characteristics. Using the solution of the hyperbolic system as the initial condition, we then solve the parabolic system by a Galerkin finite element method for space discretization and a finite difference scheme for time stepping. The proposed technique can be used for solving multi-dimensional, transient, coupled or simultaneous flows of convection-conduction type. Application to a flow example shows that the technique indeed exhibits optimality in convergence and in stability.     

基于生物信息学探讨骨质疏松症与2型糖尿病的关系

目的：基于生物信息学探讨骨质疏松症与 2 型糖尿病的关系。方法：通过基因表达汇编（GEO）数据库检索骨质疏松症和2型糖尿病的相关数据集,并筛选骨质疏松症-2型糖尿病共同差异表达基因,将数据导入STRING数据库找寻关键基因,以一个单细胞测序数据集作为检验集验证关键基因细胞层面的表达水平,对筛选结果进行基因本体（GO）功能及京都基因与基因组百科全书（KEGG）通路富集分析,并对关键靶点、相关中药进行频数统计及功效分类。结果：骨质疏松症与 2 型糖尿病相关通路集中在 ErbB信号通路、丝活化蛋白激酶（MAPK）信号通路、神经营养素信号通路、NOD样受体信号通路。频数统计结果显示,与骨质疏松症-2型糖尿病关键基因相关的中药有51味,以功效分类,可分为清热解毒药、止痛药、祛风药、补虚药、止呕药。结论：骨质疏松症和2型糖尿病都是复杂的代谢性疾病,涉及众多基因表达网络和信号通路。尽管两种疾病存在复杂的基因网络背景,但是分析结果表明两种疾病之间仍存在高度重合的差异基因表达和信号通路。这表明两种疾病的分子机制密切相关,可能存在共同调控的靶点,因此这些靶点可能成为药物同时干预两种疾病的治疗靶点。     

基于网络药理学与分子对接技术探讨青蛇方外用治疗湿疹的作用机制

目的：基于网络药理学与分子对接技术探讨青蛇方外用治疗湿疹的作用机制。方法：应用TCMSP和UniProt数据库平台查询青蛇方组方的有效活性成分及靶基因,与疾病靶基因取交集后构建蛋白质-蛋白质相互作用(PPI)网络;应用DAVID数据库,对潜在核心作用靶点基因进行基因本体（GO）功能、京都基因与基因组百科全书（KEGG）通路富集分析。利用分子对接原理论证青蛇方生物活性成分与核心靶点的分子结合能力。结果：筛选出青蛇方有效成分63种,作用靶点99个;主要有β-谷甾醇、2,4,7-三羟基-9,10-二氢菲、靛蓝素、豆甾醇、色氨酸等关键成分;转录因子AP-1（JUN）、肿瘤坏死因子（TNF）、原癌基因（RELA）、干扰素γ（IFNG）、转化生长因子-β1（TGF-β1）等核心基因。关键信号通路有癌症信号通路、恰加斯病通路、弓形体病通路、脂质和动脉粥样硬化通路等,分子对接结果显示活性成分与核心靶点基因结合能力较强。结论：青蛇方外用可以通过多种活性成分、多种通路有效抑制免疫炎症反应,促进免疫系统正常运行,从而达到治疗湿疹的目的。     

中国兴凯湖北岸平原晚全新世花粉记录及泥炭沼泽形成

通过兴凯湖北岸平原泥炭剖面高分辩率花粉分析研究，对晚全新世花粉划分4个组合带。XKH-4组合时期(1857～1746aB．P．)为沼泽发育前期，这一时期花粉浓度小，陆生草本植物占优势，气候干冷。XKH-3组合时期(1746～1287aB．P．)为沼泽发育早期，这一时期花粉浓度较大，且水生植物花粉含量为剖面最高，喜温落叶阔叶植物大发展时期，气候温和湿润。XKH-2组合时期(1287～602aB．P．)为沼泽发育中期，这一时期花粉浓度最小，但以陆生草本植物为主，木本植物为辅，水生植物急剧减少，针叶植物出现两次高峰，气候向冷干方向发展。XKH-1组合时期(602aB．P．至今)为沼泽发育盛期，这一时期花粉浓度最大，陆生草本植物大发展时期，气候波动较大。     

Experimental study on reduction of U (Ⅵ) by an anaerobic bacterium, Shewanella putrefaciens: Application to sandstone-hosted interlayer oxidation-zone type uranium deposits, China

An experimental study on reduction of U (Ⅵ) by anaerobic bacteria, Shewane//a putrefaciens, is first reported here in China. The experimental conditions were: 35℃ and pH =7.0-7.4, corresponding to a physicochemical environments in which the sandstone-hosted interlayer oxidation-zone type uranium deposit formed in Northwest China's Xinjiang. Bacteria adopted in the present experiment, Shewanella putrefaciens, occur extensively in natural environment. Our study shows that nano-crystal precipitates of uraninite quickly occurred on the surface of the cells within one week. It was found that the pitchblende was characterized by a random arrangement of uraninite nanocrystals (2-4 nm) in it, significantly different from natural pitchblende in which uraninite nanocrystals are arranged in order. Finally, a possible mechanism of uranium biomineralization by microorganisms in the deposits is discussed. Our investigation may supply a technical train of thoughts for bioremediation of nuclear-contaminated water environments and for underground dissolving extraction of the sandstone-hosted uranium ores.     

常州市数字化测绘工程及GIS建库概述

数字化地形图和地籍图是城市规划、建设和管理及国土资源管理的重要基础资料．也是开展数字城市和信息化建设的最基础平台。通过对系统总体结构的设计和应用成果介绍，分析了目前基础地理数据生产、管理和应用的现状，介绍了基于GIS的常州市数字化地形图、地籍图测绘工程总体目标及基础地理信息系统总体设计．并概述了整个数字化测绘工程的实施过程和特点。     

前方交会法测定建筑物主体倾斜

通过建筑物倾斜观测实例,介绍了应用前方交会法进行倾斜观测的方法、精度要求及注意事项。     

基于三层C/S模式的测量在线数据处理服务

讨论了测量数据处理软件的在线实现问题;并基于三层C/S模式,探讨了从客户端、中间层到后端数据处理模块的实现方法;最后以三角网平差作为实例,详细说明了用.Java语言实现一个网上测量在线数据处理服务系统的全过程.