基于网络药理学与分子对接技术探讨青蛇方外用治疗湿疹的作用机制

目的：基于网络药理学与分子对接技术探讨青蛇方外用治疗湿疹的作用机制。方法：应用TCMSP和UniProt数据库平台查询青蛇方组方的有效活性成分及靶基因,与疾病靶基因取交集后构建蛋白质-蛋白质相互作用(PPI)网络;应用DAVID数据库,对潜在核心作用靶点基因进行基因本体（GO）功能、京都基因与基因组百科全书（KEGG）通路富集分析。利用分子对接原理论证青蛇方生物活性成分与核心靶点的分子结合能力。结果：筛选出青蛇方有效成分63种,作用靶点99个;主要有β-谷甾醇、2,4,7-三羟基-9,10-二氢菲、靛蓝素、豆甾醇、色氨酸等关键成分;转录因子AP-1（JUN）、肿瘤坏死因子（TNF）、原癌基因（RELA）、干扰素γ（IFNG）、转化生长因子-β1（TGF-β1）等核心基因。关键信号通路有癌症信号通路、恰加斯病通路、弓形体病通路、脂质和动脉粥样硬化通路等,分子对接结果显示活性成分与核心靶点基因结合能力较强。结论：青蛇方外用可以通过多种活性成分、多种通路有效抑制免疫炎症反应,促进免疫系统正常运行,从而达到治疗湿疹的目的。     

An examination of directional discontinuities and magnetic polarity changes around interplanetary sector boundaries usingE > 2 keV electrons

Past studies of interplanetary magnetic sector boundaries have been based on the assumption that one can determine the field polarities by comparing the field directions with those of the nominal Parker spiral angles. Previous investigators have found evidence for decreases of B, the magnitude of the magnetic fieldB, and increases of , the angle betweenB and the ecliptic plane, at sector boundaries. Others have argued that the characteristic thickness of sector boundaries exceeds that of tangential discontinuities, making sector boundaries a separate class of structures.We use a simple technique for inferring the polarities of interplanetary magnetic fields based on the assumption thatE > 2 keV electrons are always flowing along the magnetic field away from the Sun. Electron data from the UC Berkeley experiment on the ISEE-3 spacecraft are used to examine periods around several apparent sector boundaries in 1978 and 1979. We compare properties of (a) boundaries with field polarity changes and (b) large-angle ( > 60°) directional discontinuities with no field polarity changes. We find no significant differences between the sector boundaries and the directional discontinuities in terms of associated decreases in B or of values of . These results suggest no significant difference between sector boundaries and directional discontinuities other than the change in field polarities. Within limited statistics we find that about half the polarity changes would not have been identified using a requirement that > 90° and that half of the > 120° discontinuities would have been misidentified as polarity changes.     

Doppler velocity measurements made with a scanning photoelectric magnetograph

We discuss the problems connected with the measurements and evaluation of line-of-sight velocities, obtained with a scanning photoelectric magnetograph using a line-shifter with enhanced sensitivity. We bring arguments for the validity of the results of our photoelectric Doppler velocity recordings. We have found a network of cellularly shaped patterns in the distribution of photo-electrically measured line-of-sight motions, upflowing in the magnetically quiet (blue-shifted) and downflowing in magnetically active (red-shifted) areas of the photosphere, if the mean velocity level is estimated for a sufficiently large measured area. The features of both directions are mutually complementary. We demonstrate the effect of the shift of the reference zero velocity level on the topology of the line-of-sight velocity maps, and the dependence of this level on the size of the area from which it is estimated.     

Dynamical evolution of NEAs: Close encounters, secular perturbations and resonances

We discuss the main mechanisms affecting the dynamical evolution of Near-Earth Asteroids (NEAs) by analyzing the results of three numerical integrations over 1 Myr of the NEA (4179) Toutatis. In the first integration the only perturbing planet is the Earth. So the evolution is dominated by close encounters and looks like a random walk in semimajor axis and a correlated random walk in eccentricity, keeping almost constant the perihelion distance and the Tisserand invariant. In the second integration Jupiter and Saturn are present instead of the Earth, and the 3/1 (mean motion) and v ₆ (secular) resonances substantially change the eccentricity but not the semimajor axis. The third, most realistic, integration including all the three planets together shows a complex interplay of effects, with close encounters switching the orbit between different resonant states and no approximate conservation of the Tisserand invariant. This shows that simplified 3-body or 4-body models cannot be used to predict the typical evolution patterns and time scales of NEAs, and in particular that resonances provide some fast-track dynamical routes from low-eccentricity to very eccentric, planet-crossing orbits.On leave from the Department of Mathematics, University of Pisa, Via Buonarroti 2, 56127 Pisa, Italy, thanks to the G. Colombo fellowships of the European Space Agency.     

基于“3N”理念的德化县旅游资源开发思路

现代社会的都市化及人工化,引发人类种种生理、心理问题,生活在钢筋水泥森林中的都市人逃出“现代围城”的欲望日益强烈,让身心回归真正的自然,于是“3N”旅游应运而生。本文结合德化县的实例,探讨“3N”旅游及其产品的开发问题。     

战略环境评价若干问题研究

分析了传统环境影响评价制度的不足，回顾了战略环境评价的研究与实践进展，阐述了战略环境评价与环境可持续发展的关系，并对以实现环境可持续发展为目标的战略环境评价体系所存在的问题进行了分析。     

淇、卫河流域“96·8”致洪暴雨过程的数值模拟

应用LASGREMM模式 ,对淇、卫河流域“96·8”致洪暴雨过程进行了模拟预报分析。结果表明 ,LAS GREM模式不仅能较准确地预报淇、卫河流域暴雨落区 ,而且可以进一步分析天气过程的特点及演变情况     

壳幔混染作用——下扬子区早中生代玄武岩同位素地质特征

下扬子区中生代（231Ma）玄武质火山岩全岩εNd（t）值-8.62～1.92,87Sr/86Sr 值0.7074～0.7179，206Pb/204Pb值为17.786～18.323。岩石中含有前寒武纪捕虏晶锆石。研究表明玄武质岩石可能是由亏损地幔与元古宙地壳岩石混染作用的结果。