基于网络药理学探究补阳还五汤治疗颈椎病的作用机制

目的：基于网络药理学与分子对接技术分析补阳还五汤治疗颈椎病的作用机制。方法：使用TCMSP、化学专业数据库获取补阳还五汤的活性成分,并对潜在靶点进行预测及规范。分别从PharmGKB、DisGeNET、OMIM、GeneCards数据库中得到颈椎病疾病靶点,利用韦恩图获取补阳还五汤与颈椎病的交集靶点。通过CytoScape软件构建中药-活性成分-疾病靶点和蛋白质-蛋白质相互作用（PPI）网络,获得核心有效成分与关键靶点,利用David数据库对潜在靶点进行富集分析。最后运用AutoDock Vina软件对补阳还五汤核心有效成分与关键靶点进行分子对接验证。结果：共获得补阳还五汤治疗颈椎病的有效活性成分97个,包括槲皮素、山柰酚、黄芩素、木犀草素等;交集靶点64个,关键靶点有白细胞介素-6（IL-6）、肿瘤坏死因子（TNF）、丝氨酸/苏氨酸蛋白激酶1（AKT1）、白细胞介素-1B（IL-1B）等;主要涉及肿瘤坏死因子（TNF）、白细胞介素-17（IL-17）、磷脂酰肌醇3-激酶（PI3K）/蛋白激酶B（Akt）等信号通路,分子对接结果显示核心有效成分与关键靶点之间结合紧密,为补阳还五汤治疗颈椎病提供相应条件。结论：该研究在总体上预测了补阳还五汤治疗颈椎病的活性成分、靶点和信号通路,作用途径广泛,为下一步的临床应用提供参考及思路。     

淄博市淄川区规范土地交易市场建设

规范、完善的土地交易市场，不仅是地方经济社会发展与成熟的重要标志，也是保证土地资源参与宏观调控的有利手段。近年来，淄博市国土资源局淄川区分局为进一步加强土地管理，积极发挥有形土地市场的作用，满足地方经济发展用地需求，逐步探索出了土地交易市场建设“一二三四五”的工作思路，不仅扭转了土地需求决定土地供给的局面，而且创造了良好的用地环境，为淄川区的经济发展注入了强大活力。     

基于岩溶水动态的岩溶地面塌陷预测预报方法

由于突发性、影响因素多样性等特点,岩溶地面塌陷的预测预报目前只能做到区域上的危险区划定,而不能实现危险区内何时、何处发生塌陷的预测预报。已有岩溶地面塌陷调查结果表明,岩溶地面塌陷的发生是有前兆的,即附近水井会提前出现水位波动大、水浑浊等现象。本文据此提出了建立健全岩溶水监测网络,对岩溶水位、水量、浊度及主要化学组分等指标进行实时动态监测,结合岩溶水流向等参数,实现短时间（数小时至数日）、小范围（小于监测网络间距）的较高精度岩溶地面塌陷预测预报的方法,并以山东省莱芜市孟家庄地区为例做了简要说明。      

卡里马塔海峡水体交换的季节变化

Four trawl-resistant bottom mounts, with acoustic Doppler current profilers(ADCPs) embedded, were deployed in the Karimata Strait from November 2008 to June 2015 as part of the South China Sea-Indonesian Seas Transport/Exchange and Impact on Seasonal Fish Migration(SITE) Program, to estimate the volume and property transport between the South China Sea and Indonesian seas via the strait. The observed current data reveal that the volume transport through the Karimata Strait exhibits significant seasonal variation. The winteraveraged(from December to February) transport is –1.99 Sv(1 Sv=1×10~6 m~3/s), while in the boreal summer(from June to August), the average transport is 0.69 Sv. Moreover, the average transport from January 2009 to December2014 is –0.74 Sv(the positive/negative value indicates northward/southward transport). May and September are the transition period. In May, the currents in the Karimata Strait turn northward, consistent with the local monsoon. In September, the southeasterly trade wind is still present over the strait, driving surface water northward, whereas the bottom flow reverses direction, possibly because of the pressure gradient across the strait from north to south.     

塔克拉玛干沙漠和田河西侧胡杨沙堆的形态特征及空间分布格局

胡杨沙堆是风沙流遇到胡杨干扰,沙物质堆积而形成的一种风积地貌类型。在风沙地貌领域,对胡杨沙堆的研究几乎空白。和田河西侧、麻扎塔格山以南的塔克拉玛干沙漠中分布有大量胡杨沙堆。基于野外RTK测量数据,利用GIS和统计手段,对胡杨沙堆进行信息提取与统计,定量分析了和田河西侧10个样方内胡杨沙堆的形态参数及沙堆空间分布格局。结果表明:1)沙堆形态不规则,形态参数空间差异显著,南北向形态参数均值变化较东西向稳定; 2)样方内沙堆形态参数间有良好的相关性,大部分沙堆处于发育阶段; 3)沙堆分布较稀疏,自西向东沙堆分布密度逐渐增大,从南到北为减小-增大-减小的变化趋势,总体上南部密度大于北部,东部密度大于西部; 4)10个样方沙堆与特定距离的随机分布差异性较小,整体上为离散分布,但东部较西部、北部较南部有小部分区域聚集分布。     

基于MODIS数据的新疆叶尔羌河流域山区积雪特征分析

科学监测新疆叶尔羌河流域山区积雪面积及其变化特征对该区域的气候研究、雪水资源开发利用、环境灾害预报和生态环境保护等方面有重要意义. 利用2000-2012年近13 a的MOD10A2积雪产品提取研究区域内积雪,结合DEM数据分析研究区内积雪面积的动态变化特征. 结果显示：新疆叶尔羌河流域山区的积雪面积的年际变化幅度较大,其中,2005年和2009年积雪面积较大,2007年则为典型少雪年;年内变化差异显著,总体上呈现“M”型的特点,12月和3月处于高位,2月和8月处于低谷. 叶尔羌河流域山区积雪覆盖率随着海拔的上升逐渐增大,稳定积雪主要分布在海拔5 000 m以上的地区;不同坡向的积雪覆盖率差异比较明显,西北坡、东坡、东北坡的积雪覆盖率比北坡、东南坡、西坡、南坡的积雪覆盖率高,西北坡高达52.8%,南坡仅为20%. 叶尔羌河流域山区的积雪面积与气温呈负相关,与降水量呈正相关,积雪面积变化对气温因素更为敏感.     

Observations of the Karimata Strait througflow from December 2007 to November 2008

In order to quantitatively estimate the volume and property transports between the South China Sea and Indonesian Seas via the Karimata Strait, two trawl-resistant bottom mounts, with ADCPs embedded, were deployed in the strait to measure the velocity profile as part of the South China Sea-Indonesian Seas transport/exchange (SITE) program. A pair of surface and bottom acoustic modems was employed to transfer the measured velocity without recovering the mooring. The advantage and problems of the instruments in this field work are reported and discussed. The field observations confirm the existence of the South China Sea branch of Indonesian throughflow via the Karimata Strait with a stronger southward flow in boreal winter and weaker southward bottom flow in boreal summer, beneath the upper layer northward (reversal) flow. The estimate of the averaged volume, heat and freshwater transports from December 2007 to March 2008 (winter) is (-2.7 ± 1.1) × 10 6 m3/s, (-0.30 ± 0.11) PW, (-0.18 ± 0.07) × 106m3/s and from May to September 2008 (summer) is (1.2 ± 0.6) × 106m3/s, (0.14 ± 0.03) PW, (0.12 ± 0.04) × 106m3/s and for the entire record from December 2007 to October 2008 is (-0.5 ± 1.9) × 10 6 m3/s, (-0.05 ± 0.22) PW, (-0.01 ± 0.15) × 106m3/s (negative/positive represents southward/northward transport), respectively. The existence of southward bottom flow in boreal summer implies that the downward sea surface slope from north to south as found by Fang et al. (2010) for winter is a year-round phenomenon.     

Warming and depth convergence of the Arctic Intermediate Water in the Canada Basin during 1985-2006

The warming of the Arctic Intermediate Water (AIW) is studied based on the analyses of hydrographic observations in the Canada Basin of the Arctic Ocean during 1985-2006. It is shown that how the anomalously warm AIW spreads in the Canada Basin during the observation time through the analysis of the AIW temperature spatial distribution in different periods. The results indicate that by 2006, the entire Canada Basin has almost been covered by the warming AIW. In order to study interannual variability of the AIW in the Canada Basin, the Canada Basin is divided into five regions according to the bottom topography. From the interannual variation of AIW temperature in each region, it is shown that a cooling period follows after the warming event in upstream regions. At the Chukchi Abyssal Plain and Chukchi Plateau, upstream of the Arctic Circumpolar Boundary Current (ACBC) in the Canada Basin, the AIW temperature reached maximum and then started to fall respectively in 2000 and 2002. However, the AIW in the Canada Abyssal Plain and Beaufort Sea continues to warm monotonically until the year 2006. Furthermore, it is revealed that there is convergence of the AIW depth in the five different regions of the Canada Basin when the AIW warming occurs during observation time. The difference of AIW depth between the five regions of the Canada Basin is getting smaller and smaller, all approaching 410 m in recent years. The results show that depth convergence is related to the variation of AIW potential density in the Canada Basin.     

Screening of marine fungus from Nanji Island and activity of their metabolites against pathogenic Vibrio from Pseudosciaena crocea

Seventy-eight marine fungal strains were isolated from sediment samples collected off the coast of Nanji Island,Wenzhou,Zhejiang Province,China.Antibacterial screening using the agar disc method showed that 19 of the isolated strains could inhibit at least one pathogenic Vibrio from Pseudosciaena crocea.Subsequent screening confirmed that nine strains produced antibacterial metabolites that had activity against one or several types of pathogenic Vibrio.Strain NJ0104 had the widest antimicrobial spectrum and strong activity,particularly against Vibrio parahaemolyticus-MM0810072.A preliminary study of NJ0104 antibacterial metabolites demonstrated that they had thermal stability up to 80°C,ultraviolet stability up to 40 min and pH stability between 4.0-7.0.In addition,the antibacterial metabolites were readily soluble in butanol.To identify the specific strain,the ITS-5.8S rDNA regions of NJ0104 were PCR amplified and sequenced.Based on the combination of phenotypic and genotypic data,the strain was identified as Arthrinium sp.     

新疆和田河流域柽柳沙堆的生物地貌发育过程(英文)

Tamarix nabkha is one of the most widespread nabkhas,distributing in the arid region of China.Based on the observations outdoors and the simulation experiments in laboratories,analysis in this paper refers to the biological geomorphologic features and growth process of Tamarix nabkhas in the middle and lower reaches of the Hotan River,Xin- jiang.And the results indicate that the ecological type of Tamarix in the study area is a kind of Tugaic soil habitat based on the deep soil of the Populus Diversifolia f...