基于网络药理学和分子对接探讨左金丸治疗肝癌的作用机制

目的：运用网络药理学和分子对接方法探讨左金丸治疗肝癌的作用机制。方法：从TCMSP和BATMAN-TCM数据库获取左金丸的化合物及其相应靶点,检索GeneCards、OMIM和TTD 3个数据库获得肝癌的相关靶基因,取两者靶基因交集得到左金丸治疗肝癌的预测靶基因;运用Cytoscape 3.7.1软件构建左金丸-化合物-靶点-肝癌和PPI网络图;运用R软件对预测靶基因进行GO和KEGG富集分析;最后运用分子对接技术对关键化合物和靶点进行验证。结果：共获取左金丸35个化合物及173个相应靶点,左金丸与肝癌的共同靶点有103个。PPI结果表明AKT1、MAPK1、TP53、JUN和RELA可能为左金丸治疗肝癌的关键靶点。富集分析示左金丸可能通过乙型肝炎、卡波西肉瘤相关疱疹病毒感染、人巨细胞病毒感染、丙型肝炎、MAPK信号通路、肝癌等信号通路抗肝癌。分子对接结果示槲皮素和黄连素均能与AKT1和MAPK1稳定结合。结论：本研究初步揭示了左金丸通过多成分、多靶点、多通路治疗肝癌的作用机制,为后续左金丸治疗肝癌提供理论参考。     

基于网络药理学-分子对接探索大黄牡丹汤治疗大肠癌的作用机制

目的：利用网络药理学-分子对接技术探索经方大黄牡丹汤治疗大肠癌的作用机制。方法：通过TCMSP、TCMID数据库获得大黄牡丹汤药物成分,通过PubChem、Swisstarget prediction数据库获得药物成分对应靶点,分析GSE113513芯片获得差异基因,随即获取大黄牡丹汤与大肠癌的共同靶点。利用R、Cytoscape、Autodock软件进行PPI、GO、KEGG、分子对接等分析。结果：获得大黄牡丹汤靶点561个,大肠癌差异基因1227个,共同靶点71个。共同靶点的通路富集分析显示主要与PPAR、p53等信号通路相关,Reactome机制分析显示大黄牡丹汤治疗大肠癌主要通过影响信号转导、免疫系统、疾病等产生作用,分子对接结果显示大肠癌核心靶点与大黄牡丹汤主要成分亲和力较好,能够有效自由结合。结论：经方大黄牡丹汤可通过多层次、多途径、多靶点发挥对大肠癌的治疗作用。     

轴压作用下双金属复合管组合作用与承载力分析

为探究轴压作用下双金属复合海底管道的组合作用与承载性能,对双金属复合海底管道进行了试验研究和理论分析。开展了不锈钢衬管材料性能试验,对比了国际主流不锈钢本构关系模型和试验结果。利用ABAQUS建立了精细化的双金属复合管道轴压试验有限元模型,系统研究了关键参数如复合工艺产生的环向复合应力、钢管初始缺陷幅值等对双金属复合管在轴压作用下力学性能的影响规律。通过对比已有轴压双金属复合管道试验结果,验证有限元模型。基于验证的有限元模型,对轴压作用下双金属复合管道的组合作用以及径厚比和材料强度对承载力的影响进行了分析。结果表明双金属复合管道的轴压极限承载力主要取决于基管的截面屈服荷载,并随着管径和材料强度的提高而增大。并依据分析结果对双金属复合海底管道的设计提出建议。     

Faith and Doubt in an American Working Landscape: The Importance of Scale,Work, and Place in Rural Development Planning

The term “working landscape” (WL) is increasingly used by American planners and policy makers to describe the rural places and livelihoods they aim to shape. This paper draws from a mixed-methods study of WL language as a collective action frame in the state of Vermont, where WL has been formalized into policy. Natural resource leaders and professionals share a common definition of WL that is supported by four key beliefs. However, interviews conducted in two representative farming communities suggest that landuse practitioners have not adopted WL language, and in some cases are skeptical of its meaning. The analysis explores potential explanations for the failure of the WL collective action frame to resonate across scales. The paper argues for a bottom-up planning approach that produces working landscapes policies that allow for diverse forms of work and accommodate the specificities of place.     

Developing and Sequencing Community Engagement and Experiential Education: A Case Study of Urban Geography Teaching and Research

Community engagement curricula and course design can provide substantial experiences for both community members and participating students. Using a case study approach, this research focuses on four steps in this process: initial community relationship forming, engaging in community service, transitioning to civic engagement, and developing a community-based research program. Narrative examples from student course evaluations position these community-based experiences as transformative for multiple parties. Institutional structures are presented as helpful entrees to engagement for students, while noting that community relationships provide contextualized, powerful, and meaningful relationships, supporting recommendations for emerging and existing community engagement programs.     

传承和发扬人文与经济地理学前辈的精神和知识体系——人文与经济地理学青年论坛综述

2018年1月27-28日,人文与经济地理学青年论坛暨第二届中国科学院区域可持续发展分析与模拟重点实验室青年论坛在北京国家会议中心成功举办。论坛以“人文与经济地理学的传承与创新：青年学者的责任与行动”为主题,来自全国100余家高校和研究机构从事人文与经济地理学相关研究的青年学者370余人参会。这说明人文与经济地理学青年学者很活跃、有热情、有担当意识。青年学者要加强学习、传承和发扬人文与经济地理学前辈的精神和知识体系,迎接人文与经济地理学繁荣发展的新时代。     

Responses of Riverbed Particles to Geomorphologic Processes in Aeolian-Fluvial Action Area: A Case Study of the Heilaigou Basin in Inner Mongolia of China

The Heilaigou basin, located in the Inner Mongolia of China, is predominantly influenced by the aeolian-fluvial actions, with complicated sediment transport conditions on the mainstream riverbed. In order to identify the relationship between sedimentary particles and geomorphic processes, mechanisms for the formation of characteristics of grain size composition were investigated by analyzing grain size parameters and external dynamic geomorphologic features. Firstly, the grain size parameters of the riverbed, stream power, maximum grain size of the wind-blown particles and HI values of the mainstream channel were calculated and analyzed, and they were used to establish multiple regression functions of grain size parameters in order to determine the effects of wind and river actions on particles. The results show that sediments in different reaches are formed in different environments: the upper stream is controlled by fluvial and aeolian processes; the sorting properties of riverbed sediments in the middle stream are worse than those in the upper stream since they are affected mainly by fluvial processes as indicated by the larger stream power there; and the particles on the downstream riverbed are likely contributed by the Kubuqi Desert. The size of particles on the riverbed depends on the hydrodynamic conditions, but is not significantly associated with the evolution of landform. Sorting is significantly related to both the hydrodynamic conditions and wind actions. Riverbed deposits brought in by winds likely become finer from the lower to the upper reaches, which are not coarser than 0.88f. Generally speaking, the stream power has a major effect on sedimentation characteristics of the riverbed, followed by wind power.     

“一带一路”战略的河南行动

"一带一路"战略是我国现代化建设与世界和平发展的一项世纪伟业。河南参与建设"一带一路"的行动,要以发挥优势、主动融入、服务大局为宗旨,把实施三大国家战略纳入"一带一路"框架内。构建全方位对外开放的新格局、大格局,努力推动基础设施联通、能源资源拓展、金融保障构筑、经贸产业深化、人文交流强化等领域的筹划与协作。完善一个载体,打造四个体系,组建大郑州都市地区,形成我国内陆腹地支撑"一带一路"的"中原板块"。     

干旱环境胁迫下农户适应性研究——基于民勤绿洲地区农户调查数据

适应能力及其评估框架为农户生计研究提供了一个新思路。本文在干旱环境背景下,借鉴农户可持续生计和适应能力相关理论,探讨民勤绿洲地区农户适应能力及适应行为。按照适应能力评估框架,构建农户适应能力评价指标体系,通过问卷和实地调查获取数据,在农户适应行为分类的基础上,测量不同适应类型农户的适应能力,分析影响农户适应类型的因素。结果表明：①从农户的适应行为来看,积极主动的适应行为选择较多,减少消费、参加社会保险等适应行为选择较少;农户适应类型中,综合适应型的比重最大,被动适应型最小。②农户的适应能力方面,各维度整体分布较为均衡,但自然能力和社会能力存在显著分异,而物质能力、金融能力、劳动能力和学习能力较均衡;不同农户适应类型中,综合适应型农户适应能力更稳定,务工主导型和被动适应型的稳定性较差。在适应能力六大维度中,物质能力在六大农户适应类型中所占比重最大,自然能力最小。③家庭物质资产、非农就业比重、社会网络、人均“退还关压”面积、受教育程度等适应能力指标对农户的适应行为选择具有显著影响。     

基于执行依赖启发式动态规划的船舶减摇鳍在线最优控制

针对船舶线性横摇系统,设计了一种基于执行依赖启发式动态规划（ADHDP）方法的在线学习最优减摇鳍控制器.在设计过程中直接使用输入输出数据获取系统状态值.利用评价网络来逼近针对船舶减摇鳍控制系统设计的性能指标函数,并通过执行网络获得最优控制律,这两个网络都是多层前馈神经网络,即反向传播（BP）神经网络.在训练过程中,这两个神经网络不仅可以使用实时测量数据,也可以减少船舶横摇模型的内部误差和不确定性干扰的影响,从而提高系统的鲁棒性.最后,仿真结果表明所提出的ADHDP控制器对于降低船舶横摇有很好的控制效果.