噻唑烷酸对肝组织GSH含量的影响及其作用机制的研究

建立丁胱亚磺酰亚胺(L-Buthionine Sulfoximine,BSO)排空小鼠肝组织谷胱甘肽(Glutathione,GSH)模型,研究噻唑烷酸(N-acetyl-glucosamine-thiazolidine-4(R)-carboxylic acid,GlcNAcCys)提高肝组织GSH含量,保护肝脏免受外源性毒物、药物损伤的可能机制。正常对照组小鼠腹腔注射生理盐水,BSO组及GlcNAcCys不同剂量组小鼠注射BSO(6mmol/kg体质量,i.p.)。2 h后,正常对照组和BSO组注射生理盐水,GlcNAcCys低、中、高剂量组分别注射不同剂量的GlcNAcCys(200、4009、00 mg/kg体质量)。6 h后,用Ellman’s法测定肝匀浆总巯基(Total Sulfhydryl,T-SH)含量;荧光分光光度法测定GSH含量;用试剂盒检测肝匀浆中谷胱甘肽还原酶(Glutathione Reductase,GR)和谷胱甘肽-S转移酶(Glutathione S-transferase,GST)活性;RT-PCR法检测谷氨酰半胱氨酸连接酶催化亚基(Glutamyl-L-cysteine Ligase,GCL)基因表达。GlcNAcCys能够提高肝匀浆中T-SH和GSH含量,增强抗氧化酶GR、GST活性,RT-PCR结果显示,GlcNAcCys能够诱导GCL mRNA的表达。GlcNAcCys能够提高肝组织T-SH、GSH的含量,增强GST、GR酶活力,增强肝脏的解毒功能,保护肝脏免受毒性中间代谢物的损伤。GlcNAcCys提高肝组织T-SH、GSH含量的机制与其诱导GCLmRNA的表达有关。     

中国经济增长与制度变迁的空间面板数据分析

以North的体制经济学为理论依据,将新古典经济学的Solow增长模型扩展为一个包含制度变量的计量经济学模型,并结合空间面板数据分析方法,使用1997—2005年中国省区的社会经济数据实证检验了经济制度环境对经济增长的影响。研究结果表明:该时期的制度变迁对中国的经济增长具有显著贡献力,证实了North的制度经济学理论假设。此外,空间面板数据的分析方法深入地揭示了省域经济活动之间存在的空间自相关性,即地区之间通过技术扩散、要素转移以及社会文化交流等在地理空间上发生相互影响。     

Geochronology and geochemistry of leucosomes in the North Dabie Terrane, East China: implication for post-UHPM crustal melting during exhumation

Migmatites are widespread in the North Dabie ultrahigh-pressure metamorphic terrane (NDT) of Dabie orogen, East China. Idiomorphic and poikilitic amphibole grains in both leucosome and melanosome contain inclusions of plagioclase, quartz and biotite, suggesting formation of leucosome by fluid-present melting of biotite + plagioclase + quartz-bearing protoliths at P = 5–7 kbar, T = 700–800 °C. Precise SIMS zircon U–Pb dating indicates that migmatization of Dabie orogen initiated at ~140 Ma and lasted for ~10 Ma, coeval with the formation of low-Mg^# adakitic intrusions in Dabie orogen. Based on mineralogical, petrographic and geochemical data, leucosomes in NDT can be subdivided into three groups. (1) High La/Yb_(N)–Medium Sr/Y group (Group I), whose high Dy/Yb_(N) but medium Sr/Y ratios are caused by amphibole and plagioclase residual during partial melting of dioritic to granodioritic gneisses. (2) Low La/Yb_(N)–Low Sr/Y group (Group II), whose flat HREE patterns are produced by entrainment of peritectic amphiboles into melts derived from partial melting of dioritic gneiss. (3) High La/Yb_(N)–High Sr/Y and Eu^# group (Group III), whose extremely high Sr and Eu but low other REE concentrations are caused by accumulation of plagioclase and quartz. Although Group I and III fall in the adakitic fields on La/Yb_(N)–Yb_(N) and Sr/Y–Y diagrams, they are chemically distinct from contemporary high-pressure adakitic intrusions in Dabie orogen in a series of geochemical indexes, for example, lower Dy/Yb_(N) and/or Sr/Y ratios at given La/Yb_(N) ratio, lower Sr/CaO ratios, lower Rb concentration but higher K/Rb ratios. Therefore, leucosomes are produced by anatexis of the exhumed ultrahigh-pressure metamorphic rocks at middle crustal level, instead of partial melting of thickened lower crust with garnet-rich and plagioclase-poor residual. The coeval occurrence of migmatites and high-pressure adakitic intrusions in Dabie orogen indicates large-scale partial melting of middle to thickened lower crustal column in the early Cretaceous. The required heat source may be the mantle heat conducting through the lithospheric mantle whose lower parts have been convectively removed.     

青藏高原东北部新近纪古流向与物源分布对隆升的响应

通过对青藏高原东北部11个新近纪沉积盆地的沉积相演化、古流向和物源演变的详细对比研究,揭示了研究区新近纪4次沉积演变与构造隆升的响应.①中新世早期(23～19.5Ma):阿牙克库木湖、柴达木、德令哈和酒泉盆地的古流向和物源分析表明东昆仑和阿尔金已经抬升成剥蚀区.循化、贵德和临夏等盆地物源和古流向指示西秦岭和拉脊山也已成为隆起区.区域上整体地势差异不显著.②中新世早中期(17.5～15Ma):区域湖盆面积扩大,阿牙克库木湖、索尔库里、柴达木和酒泉盆地的资料反映东昆仑、阿尔金和祁连山已经全面隆升,贵德循化、临夏盆地的古流向反映为盆地周缘型,指示西秦岭和拉脊山明显抬升,区域差异隆升造成盆地凹陷扩张进入湖泛期.③中新世中晚期(10～7Ma):阿牙克库木湖、索尔库里、柴达木和酒泉盆地沉积物的粒径和沉积速率增大,与热年代学证据一致,揭示出阿尔金山和祁连山进一步快速隆升.贵德、循化和临夏盆地古流向和物源反映为显著的多源性,除西秦岭和拉脊山外,位于循化和临夏两盆地间的积石山也开始隆起.④上新世(5.3Ma以来):索尔库里、柴达木和酒泉盆地古流向没有明显变化,沉积速率和粒径继续增大,阿尔金和祁连山加速隆升为高海拔地貌.贵德盆地主物源区是拉脊山.区域上,地势差异加强,湖盆被肢解后逐步萎缩消亡.     

第四纪以来塔里木河流域对罗布泊的钾离子输运量

研究塔里木盆地周边河流对罗布泊盐湖的盐分补给,对于研究罗布泊盐湖钾盐物质来源具有重要意义。文章在分析前人对塔里木盆地气候、温度、径流量变化等研究的基础上,分别根据竺可桢近5000年的古温度曲线、青藏高原古里雅冰芯δ¹⁸O记录的古气候变化及六盘山朝那黄土剖面磁化率记录的古温度变化,得出了近5000年、12万年、200万年的温度变化,并根据温度-径流量变化模型,估算了塔里木河流域三源流在研究时段内的径流总量。根据径流总量和河水中的K⁺浓度,估算了第四纪200万年以来塔里木河流域河水对罗布泊钾离子的输运量。     

基于总梯度模分析的磁源体边界信息提取及找矿意义

低纬度地区磁异常的化极处理极不稳定,甚至出现奇异现象。因此,低纬度地区磁异常的化极处理一直是位场研究的难点。磁异常总梯度模的曲线形态与磁化强度的大小及方向无关,且其极大值位置与磁源边界具有一定的对应性,模型试验表明了该方法在低纬度地区磁异常分析与解释方面的有效性。本文将基于总梯度模的磁异常分析方法应用于老挝爬立山铁矿区的磁测资料处理,由此排除了由化极不稳定导致的虚假磁异常,圈定了矿致异常的分布范围,进一步指导矿区铁矿勘探。已完成的钻孔资料证明,由该方法确定的磁异常区域与区内磁铁矿体分布位置的吻合性较好。由此表明,该方法对低纬度区磁异常分析与解释具有重要的意义。     

喜马拉雅中东部镜像均衡重力异常的形成研究

青藏高原南缘处于重力不均衡状态,由北向南可依次分为高原近重力均衡区、喜马拉雅山正均衡异常区和山前盆地负均衡异常区,正、负异常呈现壮观的镜像分布。本文选取喜马拉雅中东部的均衡重力异常数据,结合地貌高程、地壳厚度、降雨量、冰川及山前沉积等的分布状况,探讨地貌分异与均衡重力异常分布的相互关系。由上述资料获得3条跨越喜马拉雅山的综合剖面,结果显示喜马拉雅中东部正均衡重力异常的分布与冰川、河流等代表的地表剥蚀作用存在明显的空间耦合关系,而与降雨量无直接联系,山前盆地负均衡重力异常与沉积厚度的分布也存在很好的耦合。利用数值模型计算得到了喜马拉雅地区的均衡调整时间域在1 Ma左右的时间尺度内。通过与地貌响应时间域相对比,以及对地表剥蚀厚度的估计,认为山脉地区的正均衡异常主要由地壳厚度补偿不足引起(侧重Airy假说),而山前盆地的负均衡异常主要由低密度沉积层的分布引起(侧重Pratt假说),由于地貌响应时间快于均衡调整时间,在大约5～2 Ma以来,地壳的均衡调整始终延迟于山脉的持续剥蚀和山前的持续沉积,使得岩石圈朝着"反均衡"方向演变,最终形成了喜马拉雅现今壮观的镜像均衡重力异常分布。     

Late Mesozoic compressional to extensional tectonics in the Yiwulüshan massif,NE China and its bearing on the evolution of the Yinshan–Yanshan orogenic belt: Part I: Structural analyses and geochronological constraints

With a cratonic nucleus, the North China Craton (NCC) experienced a complex tectonic evolution with multiphase compressional and extensional events during Mesozoic times. Along the northern part of the NCC, the Yinshan–Yanshan fold and thrust belt was a typical intraplate orogen. Jurassic and Cretaceous continental sedimentation, magmatism, widespread intraplate characterize the Yinshan–Yanshan orogenic belt. The geodynamic significance of these tectonic events is still in dispute. In the western part of the Liaoning province, the Yiwulüshan massif crops out at the eastern end of the Yinshan–Yanshan orogenic belt. The Yiwulüshan massif presents an elliptical domal shape with a NE–SW striking long axis. The structural evolution of this massif brings new insights for the understanding of the Mesozoic plutonic–tectonic history of the NCC. A multidisciplinary study involving structural geology, geochronology, Anisotropy of Magnetic Susceptibility (AMS) and gravity modeling have been carried out. The presentation of the new results splits into two parts. Part I (this paper) deals with field and laboratory structural observations, and presents the main geochronological results. The AMS, gravity modeling data will be provided in a companion paper (Part II). The early compressional deformation (D₁) corresponds to a Late Jurassic to Early Cretaceous southward thrusting. The subsequent deformation is related to the Early Cretaceous exhumation of the Yiwulüshan massif. A detailed structural analysis allows us to distinguish several deformation events (D₂, D₃, and D₄). The Cretaceous extensional structures, such as syntectonic plutons bounded by ductile normal faults, metamorphic core complexes, and half-graben basins are recognized in many places in East Asia. These new data from the Yiwulüshan massif constitute a link between Transbaikalia, Mongolia, North China and South China, indicating that NW–SE extensional Mesozoic tectonics occurred throughout the entire region.     

河东煤田三交区块水文地质条件控气的正负耦合效应

煤层气的开采受多种地质因素的影响,不同区块的主控因素各不相同.山西河东煤田三交区块构造简单,煤岩渗透率和临储比相对其他区块较优,含气性良好,是煤层气开采的优势区块,但是区内不同气井产气量却相差很大.结合现场排采井采出水的水质分析实验与stiff图解法,综合分析各种地质因素,认为水文条件是该区块控气的主要因素,且水文地质控气存在着正负效应耦合的特殊性,合理分析水文地质特征是成功开采煤层气的关键所在.