我国低硒地带人群全血硒含量及其与大骨节病关系的研究

本文指出我国低硒环境中人群硒的营养状态受环境控制。全血硒均值与动物硒反应症临界值(0.02微克/毫升)相同,其时空和在人群中的变化规律与大骨节病流行病学规律相一致。人体硒营养水平与发病率呈非常显著之负相关,提示大骨节病可能是典型的人体硒反应症。

A STUDY OF THE RELATION BETWEEN THE WHOLE BLOOD SELENIUM CONTENT OF THE POPULATION AND KASCHIN-BECK DISEASE IN THE LOW SELENIUM REGIONS IN CHINA

The whole blood selenium content of the population is 0.009-0.020μ/ml according to 327 cases (5-60 years old) in 12 low selenium sites, and in 246 cases (5-15 years old) the content is 0.017 ± 0.008μg/ml (X ± S.D), which is the lowest selenium content seen in literature.In the normal selenium environment the whole blood selenium content of population is 0.053-0.091μg/ml according to 241 cases (5-50 years old) and 0.076 ± 0.017μg/ml (X±S.D) in 206 cases(5-15 years old).It is coincident with the literature value in low selenium regions in the world.The whole blood selenium content is in normal distribution.The whole blood selenium content of population in low selenium has the same critical value(0.020μg/ml) as Seresponsive disease in animals.The whole blood selenium content of 66,61% population is less than 0.020μg/ml.The whole blood selenium content is low in spring and high in summer in both selenium environments according to the seasonal dynamics.And the population are in poor state in lower selenium fenvironment.The whole blood content of the population who are fed with foreign commercial food is higher than that of the rural population fed with local food.The former does not suffer from kaschin-Beck disease.The selenium nutrition state of population in low selenium environment in China is strongly controlled by the selenium flux in the environment and low selenium nutrition is basic character.The rule of the temporal and spatial changes of population in selenium nutrition is Coincident with the ruel of epidemiology.The incidence is significantly in negative relation to the selenium content in human body.This is the typical Se-respounsive disease in human body.The authors suggested that the diseases related to low whole blood content according to some literature may be caused by some other diseases instead of the low selenium environment.