Studies on the antitumor activity and isolation of the glycoprotein from the gonad ofChlamys (Azumapecten) farreri |
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Authors: | Gu Qian-qun Fang Yu-chun Wang Chang-yun Xiao Hang Qin Yu-qing |
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Affiliation: | (1) Institute of Marine Drugs and Foods, Ocean University of Qingdao, 266003 Qingdao |
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Abstract: | After being degreased with acetone, the female gonad ofChlamys (Azumapecten) farreri was extracted with water, and then subjected to DEAE—cellulose column chromatography and purified by Sephadex G-100 chromatography to obtain a pure female gonad glycoprotein (FGGP). The IR spectra, electrophoresis and chemical analysis of FGGP indicated that it was a kind of acid glycoprotein and that the content of total protein and sugar were 54.8% and 40%, respectively. Pharmacological tests showed that FGGP could inhibit (inhibition rate of 40.87%) the growth of Sarcoma 180 of mice. |
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Keywords: | Chlamys (Azumapecten) farreri gonad glycoprotein antitumor activity |
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