锶,硼和氟联合作用的亚急性毒理实验及环境意义

本文以自由饮水给药方式进行了锶、硼和氟联合作用的亚急性实验，以探讨锶、硼对氟的拮抗作用。实验结果，给予小鼠200×l0^-6 F 六个月后，可使其骨氟含量显著升高(P<0.01)，肾碱性磷酸酶活力(ALP)显著增高(P<0.01)，4、5个月后血清碱性磷酸酶(ALP)活力亦显著增高(P<0.O1)，同时给予80×l0^-1 B3+、100×l0^-6Sr2+ 时，可以显著降低骨氟含量，抑制血清、肾碱性磷酸酶的活力，表明锶与硼对氟存在拮抗作用。

SUBACUTE TOXICITY TEST ON THE COMBINED EFFECT OF STRONTIUM,BORON AND FLUORINE

Subacute toxicity of combined effect of strontium (Sr ), boron (B)and fluorine (F ) was tested on mice by drinking water containingSr(+), B(3+) and F-. The results showed that F content in bones and activity of alkaline phoshatase (Al-P )in kidney increased significantly (p <0. 01 )after the test of water containing 200 ppm F - for six months. Al-P activity in serum also increased sharply (p<0. 01 )after 4. 5 months. Sr2+ and B3+addcd to the water with final concentration of 80 ppm and 100ppm respectively could induce the decrease of F content in bones and activity of Al.P in kidney and serum. This indicates that Sr and B are both antidotes to F.