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| 注射用丹红(粉针)-中间体-药材HPLC指纹图谱相关性研究 | |
| 引用本文： | 唐旭利,刘静,李国强,钟惠民,张静.注射用丹红(粉针)-中间体-药材HPLC指纹图谱相关性研究[J].中国海洋大学学报(自然科学版),2009,39(1). |
| 作者姓名： | 唐旭利 刘静 李国强 钟惠民 张静 |
| 作者单位： | 1. 中国海洋大学化学化工学院,中国海洋大学医药学院,山东,青岛,266003 2. 青岛科技大学,山东,青岛,266042 3. 安徽合肥紫金医药科技有限公司,安徽,合肥,230088 |
| 基金项目： | 国家高技术研究发展计划(863计划)，青岛市自然科学基金 |
| 摘 要： | 探讨中药指纹图谱相关性研究方法,运用Agilent 1100 DAD-HPLC高效液相色谱仪,采用色谱条件:大连依利特SinoChrom ODS-BP(250 mm×4.6 mm,5um)色谱柱,甲醇-0.1%磷酸水梯度洗脱,柱温30℃,流速1.0 mL·min-1检测波长280mm,进样量20uL.建立了的相同条件下丹红注射剂、中间体和药材的HPLC指纹图谱.所建立的指纹图谱个峰分离度较好,指纹信息完整,符合指纹图谱技术规范.进一步利用相似度分析软件进行了指纹图谱相关性分析,揭示了丹红注射剂与中间体和药材具有较好的相关性.共有峰的相对保留时间及相对峰面积参数,可作为中药注射剂质量控制的重要依据. |
| 关 键 词： | 丹红注射剂 丹参 红花 指纹图谱相关性 |
Relationship of RP-HPLC Fingerprint Among Danhong Injection,Intermediate and Raw Drugs |
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| TANG Xu-Li,LIU Jing,LI Guo-Qiang,ZHONG Hui-Min,ZHANG Jing.Relationship of RP-HPLC Fingerprint Among Danhong Injection,Intermediate and Raw Drugs[J].Periodical of Ocean University of China,2009,39(1). | |
| Authors: | TANG Xu-Li LIU Jing LI Guo-Qiang ZHONG Hui-Min ZHANG Jing |
| Institution: | 1.College of Chemistry and Chemical Engineering;School of Medicine and Pharmacy;Ocean University of China;Qingdao 266003;China;2.Qingdao University of Scince & Technology Qingdao 266042;3.Hefei ZiJin Medicine Technology Co.Ltd.;Hefei 230088;China |
| Abstract: | To discuss the method for establishing the fingerprint relationship of TCM,fingerprints of Danhong injection,intermediate and raw drugs were built by Agilent 1100 DAD-HPLC.The Danhong injection fingerprint exhibited better separation for the each peak,revealing amount of finger information,and showed good relationship between injection,intermediate and raw drugs according to the technical requirements of fingerprint on Injection of TCM.The parameters of relative retention times and peak areas for common pea... |
| Keywords: | HPLC |
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