RETRACTED ARTICLE: Quorum-sensing of bacteria and its application |
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Authors: | Guoliang Jiang Mingxia Su |
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Institution: | College of Marine Life Sciences, Ocean University of China, Qingdao 266003, P. R. China |
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Abstract: | Quorum sensing, or auto induction, as a cell density dependent signaling mechanism in many microorganisms, is triggered via
auto inducers which passively diffuse across the bacterial envelope and therefore intracellulaly accumulate only at higher
bacterial densities to regulate specialized processes such as genetic competence, bioluminescence, virulence and sporulation.
N-acyl homoserine lactones are the most common type of signal molecules. Aquaculture is one of the fastest-growing food-producing
industries, but disease outbreaks caused by pathogenic bacteria are a significant constraint on the development of the sector
worldwide. Many of these pathogens have been found to be controlled by their quorum sensing systems. As there is relevance
between the pathogenic bacteria’s virulence factor expression and their auto inducers, quorum quenching is a new effective
anti-infective strategy to control infections caused by bacterial pathogens in aquaculture. The techniques used to do this
mainly include the following: (1) the inhibition of signal molecule biosynthesis, (2) blocking signal transduction, and (3)
chemical inactivation and biodegradation of signal molecules. To provide a basis for finding alternative means of controlling
aquatic diseases by quorum quenching instead of treatment by antibiotics and disinfectants, we will discuss the examination,
purification and identification of auto inducers in this paper. |
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Keywords: | quorum sensing N-acyl homoserine lactones auto inducer quorum quenching |
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