Population-level genotyping of coat colour polymorphism in woolly mammoth (Mammuthus primigenius) |
| |
| Authors: | Claire Workman Love Dalen Sergey Vartanyan Beth Shapiro Pavel Kosintsev Andrei Sher Anders Gotherstrom Ian Barnes |
| |
| Affiliation: | 1. School of Biological Sciences, Royal Holloway University of London, Egham, Surrey, TW20 0EX, England, UK;2. Molecular Systematics Laboratory, Swedish Museum of Natural History, SE-104 05, Stockholm, Sweden;3. Department of Geography, Herzen University, nab. Moyki, 48, St. Petersburg, 191186, Russia;4. Department of Biology, The Pennsylvania State University, 208 Mueller Laboratory, University Park, PA 16802, USA;5. Institute of Plant and Animal Ecology, Russian Academy of Sciences, 202 8 Marta Street, 620144 Ekaterinburg, Russia;6. Severtsov Institute of Ecology and Evolution, Russian Academy of Sciences (RAS), 33 Leninskiy Prospect, 119071 Moscow, Russia;7. Department of Evolutionary Biology (EGS), Uppsala University, SE-752 36 Uppsala, Sweden;1. Dipartimento di Scienze della Terra, via Valperga Caluso 35, 10125 Torino, Italy;2. Departamento de Paleontología, Facultad de Ciencias Geológicas, calle José Antonio Novais, 2, Universidad Complutense de Madrid, 28040 Madrid, Spain;1. Department of Geophysics, Geological Faculty, Taras Shevchenko National University of Kyiv, Vasyl''kivska 90, 03022 Kyiv, Ukraine;2. Department of Physical Geography and Natural Management, Geographical Faculty, Chernivtsi ‘Yuriy Fed''kovych’ National University, Kotsubynskogo 2, 58012 Chernivtsi, Ukraine;1. Institute for the Material Culture History, Russian Academy of Sciences, 18 Dvortsovaya nab., St Petersburg, 191186, Russia;2. Arctic & Antarctic Research Institute, 38 Bering St., St Petersburg, 199397, Russia;3. Geological Institute, Russian Academy of Sciences, 7 Pyzhevsky per., 119017 Moscow, Russia;1. Geographical Institute “Jovan Cvijic” of the Serbian Academy of Sciences and Arts, Djure Jak?i?a 9, 11000, Belgrade, Serbia;2. Department of Historical and Dynamic Geology, University of Belgrade, Faculty of Mining and Geology, Kamenicka 6, 11000, Belgrade, Serbia;3. Geological Survey of Serbia, Rovinjska 12, 11000, Belgrade, Serbia;4. Chair of Physical Geography, Faculty of Sciences, University of Novi Sad, Trg Dositeja Obradovi?a 3, 21000, Novi Sad, Serbia;5. Department of Palaeontology, University of Belgrade, Faculty of Mining and Geology, Kamenicka 6, 11000, Belgrade, Serbia |
| |
| Abstract: | Patterns in the spatial or temporal distribution of genotypes may be indicative of natural selection. Previous work on the woolly mammoth melanocortin-1 receptor (Mc1r) gene identified three polymorphic positions that suggest Pleistocene populations may have harboured both light- and dark-haired mammoths (Rompler et al., 2006, 313: 62). Here, we extend this work and present the first population-level analysis of a functional gene in an extinct species. We genotyped the Mc1r gene in 47 woolly mammoth samples excavated from sites across the central portion of the woolly mammoths’ former range to examine the extent of variation of this polymorphism through time and across space. Only one individual was found to be heterozygous, indicating that the frequency of the ‘light’ mutant allele was very low. We conclude that light-coloured woolly mammoths would have been very rare, and may even have been non-existent if the ‘light’ mutant allele was strongly selected against in its homozygotic form. With the increasing availability of large-scale sequencing technologies, population-level datasets capable of identifying local adaptation will become increasingly attainable. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
