Kinetics of hepatic phase I and II biotransformation reactions in eight finfish species |
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| Authors: | Jaime Fernando Gonzlez Renate Reimschuessel Badar Shaikh Andrew S Kane |
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| Institution: | aSchool of Veterinary Medicine and Animal Science, Universidad Nacional de Colombia, AA 146224 Bogotá, Colombia;bCenter for Veterinary Medicine, Food Drug Administration (USFDA), Laurel, MD, USA;cCollege of Public Health and Health Professions, University of Florida, Gainesville, FL, USA |
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| Abstract: | Hepatic microsomes and cytosols of channel catfish (Ictalurus punctatus), rainbow trout (Oncorhynchus mykiss), Atlantic salmon (Salmo salar), red tilapia (Oreochromis sp.), largemouth bass (Micropterus salmoides), striped bass (Morone saxatilis), hybrid striped bass (M. saxatilis × M. crysops), and bluegill (Lepomis macrochuris) (n = 8) were used to study the kinetics of phase I (ECOD, EROD, PROD, BROD) and phase II (UDP-glucuronosyltransferase (UDPGT)-, sulfotransferase (ST)- and glutathione-s-transferase (GST)-mediated) reactions. The best catalytic efficiency for ECOD and GST activities was performed by channel catfish, Atlantic salmon, rainbow trout and tilapia. The highest EROD catalytic efficiency was for Atlantic salmon. None of the species had either PROD or BROD activities. Rainbow trout had very similar UDPGT catalytic efficiency to tilapia, channel catfish, Atlantic salmon, largemouth bass and bluegill. Sulfotransferase conjugation had no significant differences among the species. In summary, tilapia, channel catfish, Atlantic salmon and rainbow trout had the best biotransforming capabilities; striped bass, hybrid striped bass and bluegill were low metabolizers and largemouth bass shared some capabilities with both groups. |
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| Keywords: | Hepatic Phase I and II biotransformation reactions Finfish Kinetics |
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