| 负载姜黄素β-环糊精功能化纳米银诱导HepG2细胞凋亡机制 |
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| 引用本文： | 陈建平,钟赛意,秦小明,谌素华,李三宝.负载姜黄素β-环糊精功能化纳米银诱导HepG2细胞凋亡机制[J].广东海洋大学学报,2019(1):78-83. |
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| 作者姓名： | 陈建平 钟赛意 秦小明 谌素华 李三宝 |
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| 作者单位： | 广东海洋大学食品科技学院;赣南师范大学地理与环境工程学院 |
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| 基金项目： | 广东省自然科学基金博士启动项目(2016A30310332);国家自然科学基金青年科学基金项目(21602034);广东海洋大学科研启动项目(R17034) |
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| 摘 要： | 【目的】考察负载姜黄素的环糊精功能化纳米银(Ag@β-CD@Cur)诱导HepG2细胞凋亡的分子机制。【方法】采用荧光法测定Caspase 3酶活力,利用Western blotting实验测定Akt-p53-caspase3及其信号通路上的关键性的上游蛋白蛋白激酶B(Akt)蛋白、中游蛋白p53。【结果】Ag@β-CD@Cur能够诱导caspase3活性显著性的升高。Western blotting实验发现,Ag@β-CD@Cur能够通过下调Akt蛋白表达量和上调p53蛋白表达量来降低caspase 3的表达从而诱导细胞发生凋亡。【结论】Ag@β-CD@Cur通过Akt-p53-caspase3信号通路诱导Hep G2细胞凋亡。
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| 关 键 词： | Ag@β-CD@Cur HEPG2细胞 细胞凋亡 Akt-p53-caspase3信号通路 |
Preliminary study on the Molecular Mechanism of Cyclodextrin Functional Silver Nanoparticles-Loaded Curcumin Induced HepG2 Cells Apoptosis |
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| CHEN Jian-ping,ZHONG Sai-yi,QIN Xiao-ming,CHEN Su-hua,LI San-bao.Preliminary study on the Molecular Mechanism of Cyclodextrin Functional Silver Nanoparticles-Loaded Curcumin Induced HepG2 Cells Apoptosis[J].Journal of Zhanjiang Ocean University,2019(1):78-83. |
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| Authors: | CHEN Jian-ping ZHONG Sai-yi QIN Xiao-ming CHEN Su-hua LI San-bao |
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| Institution: | (College of Food and Technology,Guangdong Ocean University,Zhanjiang 524088 China;College of Geography and Environmental Engineering,Gannan Normal University,Ganzhou 314000,China) |
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| Abstract: | CHEN Jian-ping;ZHONG Sai-yi;QIN Xiao-ming;CHEN Su-hua;LI San-bao(College of Food and Technology,Guangdong Ocean University,Zhanjiang 524088 China;College of Geography and Environmental Engineering,Gannan Normal University,Ganzhou 314000,China) |
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| Keywords: | Ag@β-CD@Cur HepG2 cells cells apoptosis Akt-p53-caspase3 signal transduction pathway |
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