中国经济海藻提取物生物活性

分别采用MTT法、双碟法、酶标法、光度法和增重法测定了广西涠洲岛、广东硇洲岛、山东青岛和威海沿岸具有代表性的大型海藻提取物的抗肿瘤、抗菌、免疫、抗炎、抑制α-葡萄糖苷酶和抗氧化的活性。结果表明，鸭毛藻、松节藻、小粘膜藻和点叶藻的甲醇提取物具有选择性细胞毒活性；酸藻水相、鸭毛藻的乙酸乙酯相有较强的抗菌活性；金膜藻、网地藻、石莼和萱藻的甲醇提取物有较好的免疫抑制活性；三叉仙菜、龙须菜、海萝、绳藻和小粘膜藻的甲醇提取物有较好的免疫增强活性；细枝软骨藻、粗枝软骨藻和绳藻的甲醇提取物有显著的抗炎活性；松节藻、肠浒苔和扁江蓠的脂溶性提取物能有效地抑制α-葡萄糖苷酶的活性；褐藻多酚具有明显的抗氧化活性。

STUDY ON BIOACTIVITY OF CHINESE MARINE ALGA EXTRACTS

The extracts of 27 red alga, 27 brown alga and 8 green alga, which were collected from the coasts of Weizhou island off Guangxi Province, Naozhou island off Guangdong Province, Qingdao and Weihai in Shandong Province, were tested for anti tumor, antibacterial, immunity, anti inflammatory activity and the inhibitory effect against alpha glucosidase. Of the marine alga tested, methanol extracts of Symphyocladia latiuscula, Rhodomela confervoides, Leathesia nana and Punctaria latifolia showed marked selective cytotoxic activity; water portion of Desmarestia viridis and acetic ether portion of Symphyocladia latiuscula showed high antibacterial activity; methanol extracts of Chrysymenia wrightii, Dictyota dichotoma, Scytosiphon lomentarius and Ulva lactuca showed strong immune inhibitory activity, Ceramium kondoi, Gracilaria lemaneiformis, Gloiopeltis furcata, Chorda filum and Leathesia nana have strong immune enhancement activity; methanol extracts of Chondria tenuissima, Chondria crasscaulis and Chorda filum showed notable anti inflammatory activity; lipophilic extracts of Rhodomela confervoides, Enteromorpha intestinalis and Gracilaria textorii remarkably inhibited alpha glucosidase activity; polyphenols from brown alga could effectively prevent fish oil from being oxidized.