Chemical profile of the secondary metabolites produced by a deep-sea sediment-derived fungus Penicillium commune SD-118 |
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Authors: | Zhuo Shang Xiaoming Li Li Meng Chunshun Li Shushan Gao Caiguo Huang Bingui Wang |
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Institution: | 1. Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao, 266071, China 2. Graduate University of Chinese Academy of Sciences, Beijing, 100049, China 3. Department of Biochemistry and Molecular Biology, Second Military Medical University, Shanghai, 200433, China
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Abstract: | Bioassay-guided fractionation of the crude extract from Penicillium commune SD-118, a fungus obtained from a deep-sea sediment sample, resulted in the isolation of a known antibacterial compound, xanthocillin X (1), and 14 other known compounds comprising three steroids (2?C4), two ceramides (5 and 6), six aromatic compounds (7?C12), and three alkaloids (13?C15). Xanthocillin X (1) was isolated for the first time from a marine fungus. In the bioassay, xanthocillin X (1) displayed remarkable antimicrobial activity against Staphylococcus aureus and Escherichia coli, and significant cytotoxicity against MCF-7, HepG2, H460, Hela, Du145, and MDA-MB-231 cell lines. Meleagrin (15) exhibited cytotoxicity against HepG2, Hela, Du145, and MDA-MB-231 cell lines. This is the first report of the cytotoxicity of xanthocillin X (1). |
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Keywords: | bioguided isolation deep-sea sediment-derived fungus Penicillium commune xanthocillin X antibacterial activity cytotoxicity |
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