| 磺胺甲噁唑在黑鲪肌肉中药代动力学及残留研究 |
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| 引用本文： | 任利强,王茂剑,宫向红,孙玉增,张长坤.磺胺甲噁唑在黑鲪肌肉中药代动力学及残留研究[J].海洋湖沼通报,2009(4). |
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| 作者姓名： | 任利强 王茂剑 宫向红 孙玉增 张长坤 |
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| 作者单位： | 1. 山东省海洋水产研究所,山东,烟台,264006;上海水产大学,上海,200090
2. 山东省海洋水产研究所,山东,烟台,264006 |
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| 基金项目： | 山东省科学发展计划项目，山东省水产品质量安全监测计划，山东省‘泰山学者'建设工程专项经费资助 |
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| 摘 要： | 在13℃条件下,采用单剂量灌服的方法给黑鲪100mg/kg体重的磺胺甲噁唑(SMZ),以HPLC法测定黑鲪肌肉中的药物浓度,用DAS2.0药物代谢动力学分析软件处理药时数据,结果表明:在13℃条件下,黑鲪单次灌服SMZ的药动学房室模型符合无时滞的二房室模型,分布半衰期t_(1/2α)为5.947h,消除半衰期t_(1/2β)为12.882h,达峰时间T_(max)为8h,峰值C_(max)为40.880μg/g.经过71d的代谢,肌肉中的药物含量下降到无公害食品中所规定的＜0.1mg/kg鱼体重.
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| 关 键 词： | 黑鲪 磺胺甲噁唑 药物代谢动力学 残留 |
PHARMACOKINETICS AND RESIDUES OF SULFAMETH -OXAZOLE IN SEBASTODES FUSCESCENS MUSCLE |
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| REN Liqiang,WANG Maojian,GONG Xianghong,SUN Yuzeng,ZHANG Changkun.PHARMACOKINETICS AND RESIDUES OF SULFAMETH -OXAZOLE IN SEBASTODES FUSCESCENS MUSCLE[J].Transaction of Oceanology and Limnology,2009(4). |
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| Authors: | REN Liqiang WANG Maojian GONG Xianghong SUN Yuzeng ZHANG Changkun |
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| Abstract: | In this paper, Sebastodes fuscescens was treated orally with SMZ via stomach tube at a single dose of 100mg/kg at 13℃. The concentration was determined by High Performance Liquid Chromatography (HPLC). The concentration-time data were analyzed with DAS2.0. The results are as followed: The SMZ of muscle concentration-time data were best described by two-compartment model with no time lag. The distribution half-life (t_(1/2α)) was 5.947h, and the elimination half-life (t_(1/2β)) was 12.882h. The time of peak concentration (T_(max)) was 8h, the maximum SMZ concentration (C_(max)) was 40.88μg/g. After metabolism time of 71d, the concentration of SMZ in muscle was lower than the limit of 0.1mg/kg in organic fish product. |
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| Keywords: | Sebastodes fuscescens sulfamethoxazole pharmacokinetics residues |
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