| The chemical constituents from red alga Gymnogongrus flabelliformis Harv. |
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| 作者姓名： | 袁兆慧 韩丽君 苏华 史大永 孙杰 李帅 石建功 |
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| 作者单位： | Institute of Oceanology Chinese Academy of Sciences，Institute of Oceanology，Chinese Academy of Sciences，Institute of Oceanology，Chinese Academy of Sciences，Institute of Oceanology，Chinese Academy of Sciences，Institute of Oceanology，Chinese Academy of Sciences，Institute of Materia Medica，Chinese Academy of Medical Sciences and Peking Union Medical College，Institute of Materia Medica，Chinese Academy of Medical Sciences and Peking Union Medical College，Qingdao 266071，China，Qingdao 266071，China，Qingdao 266071，China Graduate School of Chinese Academy of Sciences，Beijing 100039，China，Qingdao 266071，China，Qingdao 266071，China，Beijing 10005，China，Beijing 10005，China |
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| 基金项目： | Funded by the Project NNSF of China (No.30530080 and 20432030) and the New Century Excellent Talent Supporting Program of Chinese Ministry of Education |
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| 摘 要： | Eight compounds were isolated from red alga Gymnogongrus flabelliformis Harv. In normal phase silica gel, Sephadex LH-20 gel column chromatography, reverse phase HPLC, and recrystallization. Based on MS and ID NMR spectroscopic data, their structures were determined as： stigmast-4-en-3-one （Ⅰ）, cholest-4-en-3-one （Ⅱ）, cholesterol （m）, uracil （Ⅳ）, uridine （V）, adenosine （Ⅵ）, succinic acid （Ⅶ）, and 5-hydroxy-4-methyl-5-pentyl-2,5-dihydro-furan-2-on （Ⅷ）. All of them were obtained from this species for the first time. Cytotoxicity of these compounds was screened using standard MTT method, but all the compounds were inactive （IC50 〉 10 μg/ml）.
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| 关 键 词： | 红藻 化学成分 MTT测量 海洋化学 |
| 收稿时间： | 4 October 2008 |
The chemical constituents from red alga <Emphasis Type="Italic">Gymnogongrus flabelliformis</Emphasis> Harv. |
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| Zhaohui?Yuan,Lijun?Han,Hua?Su,Dayong?Shi,Jie?Sun,Shuai?Li,Jiangong?Shi.The chemical constituents from red alga Gymnogongrus flabelliformis Harv.[J].Chinese Journal of Oceanology and Limnology,2008,26(2):190-192. |
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| Authors: | Zhaohui Yuan Lijun Han Hua Su Dayong Shi Jie Sun Shuai Li Jiangong Shi |
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| Institution: | [1]Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China [2]Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 10005, China [3]Graduate School of Chinese Academy of Sciences, Beijing 100039, China |
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| Abstract: | Eight compounds were isolated from red alga Gymnogongrus flabelliformis Harv. In normal phase silica gel, Sephadex LH-20 gel column chromatography, reverse phase HPLC, and recrystallization. Based
on MS and 1D NMR spectroscopic data, their structures were determined as: stigmast-4-en-3-one (I), cholest-4-en-3-one (II),
cholesterol (III), uracil (IV), uridine (V), adenosine (VI), succinic acid (VII), and 5-hydroxy-4-methyl-5-pentyl-2,5-dihydro-furan-2-on
(VIII). All of them were obtained from this species for the first time. Cytotoxicity of these compounds was screened using standard
MTT method, but all the compounds were inactive (IC50 > 10 μg/ml).
Funded by the Project NNSF of China (No. 30530080 and 20432030) and the New Century Excellent Talent Supporting Program of
Chinese Ministry of Education |
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| Keywords: | red algae Gymnogongrus flabelliformis Harv chemical constituents MTT assay |
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