| 丙脒盐酸盐的合成工艺研究 |
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| 引用本文： | 欧春艳,陈声宗. 丙脒盐酸盐的合成工艺研究[J]. 广东海洋大学学报, 2007, 27(6): 71-73 |
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| 作者姓名： | 欧春艳 陈声宗 |
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| 作者单位： | 1. 广东海洋大学理学院,广东,湛江,524088
2. 湖南大学化学化工学院,湖南,长沙,410082 |
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| 摘 要： | 采用单因子实验及均匀实验设计,考察了影响丙脒盐酸盐收率的因素,经回归分析,得出了合成丙脒盐酸盐的优化工艺条件:物料配比n(CH3CH2CN)﹕n(CH3OH)﹕n(HCl)=1﹕1.1﹕1.1;整个反应体系为无水体系;在反应前期,溶液温度为0~10℃,pH值为4.0左右,反应时间为9 h;在反应后期,溶液温度为0~20℃,pH值为8.0~8.5;氨-甲醇溶液的质量分数为15.0%。在此优化工艺条件下,丙脒盐酸盐的收率为94.0%,含量≥99%。
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| 关 键 词： | 丙腈 丙脒盐酸盐 均匀实验设计 单因子实验 |
| 文章编号： | 1673-9159(2007)06-0071-03 |
| 修稿时间： | 2007-03-14 |
Synthesis of Propionamidine Hydrochloride |
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| OU Chun-yan,CHEN Sheng-zong. Synthesis of Propionamidine Hydrochloride[J]. Journal of Zhanjiang Ocean University, 2007, 27(6): 71-73 |
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| Authors: | OU Chun-yan CHEN Sheng-zong |
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| Abstract: | The factors influencing synthesizing propionamidine hydrochloride were investigated by single factor experiment and uniform test design.The optimum process conditions were obtained by regression analysis.The optimum conditions are as follows: molar ratio of propionitrile to anhydrous methanol to hydrogen chloride 1:1.1:1.1,without any moisture,at the beginning reaction temperature 0~10℃,pH value of the solution 4.0,reaction time 9 hours;later reaction temperature 0~20℃,pH value 8.0~8.5;concentration of ammonia-methanol solution 15%.As a result,yield of propionamidine hydrochloride was up to 94.0%,with the purity of 99%. |
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| Keywords: | propionitrile propionamidine hydrochloride uniform test design single factor experiment |
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