| MECHANISM OF THE HYDROLYSIS OF ADENOSINE 5＇-TRIPHOSPHATE: A REGRESSION ANALYSIS OF KINETIC DATA |
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| 作者姓名： | D.BRYNNHIBBERT JOHNP.B.SANDALL |
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| 作者单位： | Department of Analvtical Chemistry University of New South Wales PO Box l Kensington NSW 2033 Australia AND，Departament of Chemistry Royal Holloway and Bedford New College University of London Egham Hill Egham Surrey TW20 OEX. U. K. |
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| 摘 要： | Data of the hydrolysis of adenosine 5'-triphosphate have been re-evaluated using a computer program thatnumerically integrates the differential rate equations within a routine that optimizes rate coefficients givena suitable model and concentration versus time data. The model is tested by calculation of Hamilton R-values, the Fisher F-statistic, a sensitivity analysis,the standard errors on the rate coefficients and by constructing contour maps of the objective functionversus two rate coefficients. An optimization using only phosphate concentration data cannot distinguish between a model in whichadenosine 5'-monophosphate is formed predominantly directly with a molecule of pyrophosphate, andone in which it is formed via adenosine 5'-diphosphate. A more accurate set of rate coefficients iscalculated from existing data and the relative importance of the two paths determined.
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