| 抗鳗弧菌单克隆抗体免疫保护作用的实验研究 |
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| 引用本文： | 夏永娟,黄威权,金晓航,姜国良,刘云. 抗鳗弧菌单克隆抗体免疫保护作用的实验研究[J]. 海洋湖沼通报, 2000, 0(3): 6-9 |
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| 作者姓名： | 夏永娟 黄威权 金晓航 姜国良 刘云 |
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| 作者单位： | 1. 第四军医大学组织学与胚胎学教研室,西安710032
2. 青岛海洋大学海洋生命学院,青岛266003 |
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| 基金项目： | 新材料领域项目，816-02-06， |
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| 摘 要： | 本文对鳗弧菌感染牙鲆幼鱼为动物模型，对我们制备的五株抗鳗弧菌单抗４Ａ６，３Ｂ２，４Ｅ１２，３Ｅ７，３Ａ４的免疫保护效果进行了研究，结果表明：４Ａ６，３Ｂ２和４Ｅ１２具有明显提高受５ＬＤ＾５０鳗弧菌感染的牙鲆存活率的作用，同时它们还可明显延长受大齐量鳗弧菌（１０ＬＤ＾５０）感染的牙鲆的平均存活时间，揭示：４Ａ６，３Ｂ２和４Ｅ１２具有中和或减弱鳗弧菌毒性的作用。
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| 关 键 词： | 鳗弧菌 单克隆抗体 免疫保护 鱼类 |
| 文章编号： | 1003-6482(2000)03-0006-04 |
PROTECTIVE PROPERTIES OF MONOCLONAL ANTIBODIES AGAINST VIBRIO ANGUILLARUM IN EXPERIMENTAL FLOUNDER |
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| XIA Yongjuan,HUANG Weiquan,JIN Xiaohang,JIANG Guoliang,LIU Yun. PROTECTIVE PROPERTIES OF MONOCLONAL ANTIBODIES AGAINST VIBRIO ANGUILLARUM IN EXPERIMENTAL FLOUNDER[J]. Transaction of Oceanology and Limnology, 2000, 0(3): 6-9 |
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| Authors: | XIA Yongjuan HUANG Weiquan JIN Xiaohang JIANG Guoliang LIU Yun |
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| Affiliation: | XIA Yongjuan,HUANG Weiquan,JIN Xiaohang(Department of Histology and Embryology, Fourth Military Medical University, Xi'an 710032) JIANG Guoliang,LIU Yun(College of Marine Life Sciences, Ocean University of Qingdao, Qingdao, 266003) |
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| Abstract: | The protective properties of monoclonal antibodies (mAbs) against V. anguillarum were studied in experimental flounder paralichthys olivaceus. The results showed that: (l) the survival rate of flounder challenged with 5LD50 of V. anguillarum was significantly higher in 4A6, 3B2,and 4E12 groups than in the control group (P<0.01). (2) 4A6, 3B2 and 4E12 mAbs were effective in extending the mean time of survival of 'flounders challenged with 10LD50 of V anguillarum. These results indicated that 4A6, 3B2 and 4E12 mAbs had the ability to neutralize the pathological effects of V. anguillarum. |
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| Keywords: | vibrio anguillarum monoclonal antibody immunoprotection |
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