Antiviral effects of Stichopus japonicus acid mucopolysaccharide on hepatitis B virus transgenic mice |
| |
Authors: | Yongning Xin Wei Li Linlin Lu Li Zhou David W. Victor Shiying Xuan |
| |
Affiliation: | XIN Yongning;LI Wei;LU Linlin;ZHOU Li;David W Victor;XUAN Shiying;Qingdao Municipal Hospital;Department of Gasteroenterology, Qingdao No.6 People’s Hospital;Taiyuan Infectious Diseases Hospital;Hepatology & Transplant Medicine, Department of Medicine, Houston Methodist Hospital; |
| |
Abstract: | Hepatitis B virus (HBV) is a significant global pathogen and efficient cure for HBV patients is still a challenging goal. We previously reported that acidic mucopolysaccharide from stichopus japonicus selenka (SJAMP) could inhibit HBsAg and HBeAg expression in vitro. However, the potential anti-HBV effects of SJAMP in vivo have not yet been explored. In this study, we show that SJAMP exhibits potent anti-HBV activity in HBV transgenic mice in a dose-dependent manner. Specifically, sixty HBV transgenic male BALB/c mice were randomly selected to receive the treatment of PBS, low dose SJAMP (30 mg kg?1), middle dose SJAMP (40 mg kg?1), high dose SJAMP (50 mg kg?1) and IFN (45 IU kg?1) for 30 d. SJAMP treatment suppressed serum HBV-DNA, and liver HBsAg and HBcAg levels in HBV-transgenic mice. The present study highlights the potential application of SJAMP in HBV therapy. |
| |
Keywords: | |
本文献已被 CNKI SpringerLink 等数据库收录! |
|