| 抗菌渔药筛选中最佳参数的选择与论证 |
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| 引用本文： | 王晓洁,杨立红,安艳,梁建光,孙东红.抗菌渔药筛选中最佳参数的选择与论证[J].中国海洋大学学报(自然科学版),2007,37(5):775-780. |
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| 作者姓名： | 王晓洁 杨立红 安艳 梁建光 孙东红 |
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| 作者单位： | 鲁东大学,生命科学学院,山东,烟台,264025 |
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| 摘 要： | 采用二倍稀释法测定8种常用抗菌药对致病性鳗弧菌的最低抑菌浓度(MIC)。以MIC为单位,采用1,5,10,20倍MIC下抑菌圈直径为参数,分别比较8种常用抗菌药抑杀菌效果,通过分析比较优化最佳参数。利用优化出的最佳参数,比较8种常用抗菌渔药单独用药与联合用药对鳗弧菌的抑杀菌效果。结果表明:5倍MIC下抑菌圈直径是本实验筛选抗菌药的最佳参数。在此参数下,鳗弧菌对庆大霉素和氟哌酸高度敏感;对链霉素、土霉素、盐酸诺氟沙星、氟甲砜霉素和甲砜霉素中度敏感。盐酸诺氟沙星与甲砜霉素的联合效果最好。
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| 关 键 词： | 抗菌药 鳗弧菌 抑菌圈 |
| 文章编号： | 1672-5174（2007）05-775-06 |
| 修稿时间： | 2007-03-06 |
Determination of the Best Parameters in Selecting Antibacterials |
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| WANG Xiao-Jie,YANG Li-Hong,AN Yan,LIANG Jian-Guang,SUN Dong-Hong.Determination of the Best Parameters in Selecting Antibacterials[J].Periodical of Ocean University of China,2007,37(5):775-780. |
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| Authors: | WANG Xiao-Jie YANG Li-Hong AN Yan LIANG Jian-Guang SUN Dong-Hong |
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| Institution: | College of Life Science, LuDong University, Yantai 264025, China |
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| Abstract: | The double dilution method was used to determine the minimum inhibitory concentrations(MICs) of eight kinds of antibacterial drugs.Comparing the inhibiting and anti bactericidal effects on Vibrio anguillarum respectively in the inhibition zones of 1,5,10 and 20 MICs by using the MIC as a unit the best parameter was obtained.Then the best parameter was used to compare the the inhibiting and antibactericidal effects of the antibacterials in singles and in combinations.The results show that the inhibition zone of 5 MIC is the best parameter.Under this parameter,Vibrio anguillarum is most sensitive to Gentamicinum and Norfloxacinum,followed by Streptomycinum,Oxytetracylinnum and Hydrochloric Norfloxacinum,Florfenicol and Thiamphenicol.The combination of norfloxacin and thiamphenicol has the best effect. |
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| Keywords: | MIC |
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