| The effects of TDI on mice bone marrow cells |
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| 作者姓名： | Lang LANG Yubin JI Jiang HUI |
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| 作者单位： | [1]Research Center on Life Science and Environmental Science of Harbin University of Commerce, Harbin 150002, China [2]Postdoctal Research of the Institute of Material Medical of Harbin University of Commerce, Harbin 150002, China |
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| 摘 要： | Objective： To test the effects of TDI on mice bone marrow cells. Methods： The effects of TDI were studied by laser scanning confocal microtechnique to investigate the form changing of the mice bone marrow cell and genotoxicity test-chromosomal aberration test and sister chromatic exchange （sce） test. Results： The 1/16 LC50 and 1/8 LC50 dosage of TDI had no significant effect on the fluorescence pixels of RNA/DNA by laser scanning confocal microtechnique to investigate the chromosoma laberration rate and the frequencies of sister chromatic exchange of the mice （P〉0.05）. But both 1/4 LC50 and 1/2 LC50 dosage had significant effect on the fluorescence pixels of RNA/DNA by laser scanning confocal microtechnique to investigate the chromosoma laberration rate and the frequencies of sister chromatic exchange of the mice （P〈0.01）. Conclusions： TDI has the genetic toxicity.
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| 关 键 词： | TDI 二异氰酸盐 激光扫描 染色体 骨髓 |
The effects of TDI on mice bone marrow cells |
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| Lang LANG Yubin JI Jiang HUI.The effects of TDI on mice bone marrow cells[J].Chinese Journal of Geochemistry,2006,25(B08):187-187. |
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| Abstract: | |
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| Keywords: | Toluene Diisocyanate laser scanning confocal microtechnique chromosomal aberration sister chromatic exchange DNA |
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