| 碳水化合物的组合合成 |
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| 引用本文： | 王群,于广利. 碳水化合物的组合合成[J]. 中国海洋大学学报(自然科学版), 2001, 31(1): 45 |
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| 作者姓名： | 王群 于广利 |
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| 作者单位： | 美国爱荷华大学药学院,药物与天然产物化学系, |
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| 摘 要： | 碳水化合物的组合合成是一项新兴技术，该技术可以在短时间内合成大量用于进行生物活性筛选的寡糖及拟糖物。液相与固相合成技术可以极大地加快药物研究与开发进程。作者针对该技术在碳水化合物合成方面的研究进展情况进行讨论。
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| 关 键 词： | 组合化学；液相与固相合成；寡糖；拟糖物 |
| 文章编号： | 1001-1862(2001)01-045-08 |
| 修稿时间： | 2000-03-10 |
Combinatorial Synthesis ofCarbohydrates |
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| Wang Qun Wang Yu Guangli Division of Medicinal and Natural Products Chemistry,College of Pharmacy,The University of Iowa,IA,,USA). Combinatorial Synthesis ofCarbohydrates[J]. Periodical of Ocean University of China, 2001, 31(1): 45 |
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| Authors: | Wang Qun Wang Yu Guangli Division of Medicinal Natural Products Chemistry College of Pharmacy The University of Iowa IA USA) |
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| Affiliation: | Wang Qun Wang Yu Guangli Division of Medicinal and Natural Products Chemistry,College of Pharmacy,The University of Iowa,IA,52242,USA) |
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| Abstract: | Combinatorial synthesis of carbohydrates is the newly formed technique to synthesize and biologically screen large set of oligosaccharides and glycomimetics in a very short time. Solution phase and solid phase methodology have been used in this technique to tremendously accelerate drug development process. In this paper, current approaches regarding carbohydrate synthesis in this field will be discussed. |
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| Keywords: | combinatorial chemistry solution phase and solid phase synthesis oligosaccharides glycomimetic |
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