壳聚糖季铵盐的合成及性质研究

为开发利用壳聚糖及其衍生物，采用异相法合成了壳聚糖季铵盐——羟丙基三甲基氯化铵(HACC)，并分别用红外光谱、核磁共振对其结构进行了表征；通过扫描电镜图对比分析了CS和HACC的粒度和外貌形态变化。在此基础上，测定了HACC的取代度(DQ)，并对其溶液性质进行研究。结果表明：通过在壳聚糖分子结构中N上引入季铵盐侧链合成的HACC，具有较好的水溶性和较高的稳定性，室温下水中溶解度达10％，1％醋酸水溶液粘度在12d内、水溶液粘度在pH=3～9范围内几乎没有降低。

Synthesis and Studies on Properties of Quaternary Ammonium Salt of Chitosan

Quaternary ammonium salt of chitosan (HACC) was synthesized in the heterogeneous system.The structure of HACC was characterized by IR and NMR spectroscopy,The particle size and morphology of CS and HACC were analysised by comparing the photographs of scanning electron microscope (SEM).The degree of quaternization(DQ) of HACC was measured and the properties of HACC solution were studied. The results showed that HACC had good water solubility and high stability. Its solubility in water was 10% under room temperature. The viscosity of 1% acetum hardly decreased in 12 days. And the viscosity of its aqueous solution was almost constant at pH 3-9.