| 皱纹盘鲍多糖抗肿瘤药理作用研究 |
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| 引用本文： | 许东晖,许实波,王兵,林永成,邵志宇. 皱纹盘鲍多糖抗肿瘤药理作用研究[J]. 热带海洋学报, 1999, 0(4) |
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| 作者姓名： | 许东晖 许实波 王兵 林永成 邵志宇 |
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| 作者单位： | 中山大学药学系药理学研究室!广州510275(许东晖，许实波，王兵)，中山大学化学化工学院天然有机研究室!广州510275(林永成，邵志宇) |
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| 基金项目： | 国家海洋“86 3”专项资助课题!(项目批准号 :81 9-0 4 ) |
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| 摘 要： | 对从软体动物皱纹盘鲍HaliotisdiscushannaiIno中分离提取的纯多糖进行了抗肿瘤活性研究。药理实验表明,多糖对体外培养的小鼠移植性肿瘤肉瘤S180、肝癌HepA细胞无细胞毒作用,但能明显延长HepA小鼠的生存时间,抑制小鼠移植性肉瘤S180的生长;在抑瘤的同时,能明显提高免疫器官胸腺、脾脏的重量,降低荷瘤小鼠肝脏中过氧化脂质的水平。提示鲍鱼多糖可能是通过增强荷瘤小鼠的免疫功能和抗氧化作用而发挥其抗肿瘤活性的
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| 关 键 词： | 皱纹盘鲍多糖 抗肿瘤 免疫 过氧化脂质 |
A STUDY ON ANTI-TUMOR EFFECTS OF ABALONE POLYSACCHARIDE(AP) FROM HALIOTIS DISCUS HANNAI INO |
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| Xu Donghui Xu Shibo Wang Bing. A STUDY ON ANTI-TUMOR EFFECTS OF ABALONE POLYSACCHARIDE(AP) FROM HALIOTIS DISCUS HANNAI INO[J]. Journal of Tropical Oceanography, 1999, 0(4) |
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| Authors: | Xu Donghui Xu Shibo Wang Bing |
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| Abstract: | The effects of abalone polysaccharide (AP) extracted from Haliotis discus hannai Ino on tumor inhibition were studied.AP did not exhibit cytocidal action on S 180 and HepA cells cultured in vitro. AP prolonged the survival time of the HepA mice and inhibited the growth of S 180 markedly.While inhibiting the growth of S 180 ,AP increased the weights of the thymus and spleen,decreased the level of Hepatic LPO in tumor bearing mice obviously.It was suggested that AP gave play to its anti tumor activity by increasing the immunity and anti oxidation of host. |
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| Keywords: | Haliotis discus hannai Ino abalone polysaccharide anti tumor activity immunity lipid peroxidation |
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