Structures and antiviral activities of butyrolactone derivatives isolated from Aspergillus terreus MXH-23 |
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Authors: | Xinhua Ma Tianjiao Zhu Qianqun Gu Rui Xi Wei Wang Dehai Li |
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Institution: | 1. Key Laboratory of Marine Drugs of Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, P. R. China 2. Zhangqiu Maternity and Child Health Care Hospital, Jinan, 250200, P. R. China
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Abstract: | A new butyrolactone derivative, namely butyrolactone VIII (1), and six known butyrolactones (2–7) were separated from the ethyl acetate (EtOAc) extract of the fermentation broth of a fungus, Aspergillus terreus MXH-23. The chemical structures of these metabolites were identified by analyzing their nuclear magnetic resonance (NMR) and mass spectrometry (MS). Known butyrolactone derivatives contain an α,β-unsaturated γ-lactone ring with α-hydroxyl and γ-benzyl, and butyrolactone VIII (1) was the first butyrolactones contains α-benzyl and γ-hydroxyl on α,β-unsaturated lactone ring. All of the butyrolactone derivatives were tested for their anti-influenza (H1N1) effects. Derivatives 4 and 7 showed moderate antiviral activities while the newly-identified, derivative 1, did not. |
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Keywords: | sponge-derived fungus secondary metabolite butyrolactone anti-influenza activity |
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