16层螺旋CT灌注成像在胰腺病变诊断中的应用

目的：应用多层螺旋CT（MSCT）灌注扫描成像技术评价正常人胰腺，胰腺炎与胰腺癌的血流动力学表现，并探讨其临床应用价值。方法：从26例行多层螺旋CT胰腺灌注扫描者中选出20例分析。胰腺癌组10例，正常胰腺组5例（志愿者），急性水肿性胰腺炎组5例。采用GE light speed 16层CT电影模式（0．5·s^-1），120kV，60mA，5mm×4；注射流率3．0mL·s^-1，延迟5s，扫描时间50s。应用GE ADW 4．2工作站Perfusion3灌注软件包分析，分别测量Qb，Vb,tmt和κps，采用t检验并进行统计学分析结果：所选20例受检者均获得满意的伪彩灌注图、灌注参数。胰腺癌组和正常胰腺组的灌注参数Qb、Vb、tmt和κps。均有统计学差异（P〈0．05）胰腺癌组和胰腺炎组的灌注参数Qb、Vb及tmt均有统计学差异（P〈0．05），κps均值差异无统计学意义（P〉0．05）。胰腺炎组和正常胰腺组的灌注参数Qb、K、及κps均有统计学差异（P〈0．05）。结论：胰腺MSCT灌注成像为胰腺疾病的诊断提供了新方法，并且为治疗提供了新的理论依据。胰腺癌的血流灌注与正常胰腺和胰腺炎的血流灌注相比明显减少，MSCT灌注成像对胰腺癌血流变化的分析有一定的临床应用价值。

16-Slice Spiral CT Perfusion Imaging in Diagnosis of Pancreatic Pancreatic Disease Abstract

Objective： To assess the characteristics of blood flow for normal pancreas pancreatitis and pancreatic cancer, and to discuss the clinical application value of MSCT perfusion technology. Methods： Selects 20 cases analyses from 26 example MSCT pancreatic perfusion scan. The CT perfusion imaging were obtained using GE Light speed 16 slice spiral CT scanner in 10 patients with pancreatic cancer, 5 patients with normal pancreas tissue and 5 patients with pancreatitis. With 16-CT ADW 4.2 work station apply GE light speed-16 slices CT perfusion for pancreatic with cine mode.（ 0. 5 s ^-1） 120 kV, 60 mA, 5 mm × 4. Contrast injection was done by using 50 mL nonionic contrast agent （300 nag. mLJ）, at a flow rate of 3 mL·s^-1 with power injector, 5 s delay, and data collection lasted for 50 seconds. Then perfusion 3 pancreatic software package and the mean Qb, Vb, tmt and κps were measured and t analysis was made. Results： The mean Qb, Vb and κps between pancreatic carcinoma and normal group were statistically significant （P〈0.05）, The mean Qb, Vb and tmt between pancreatic carcinoma and pancreatitis group were statistically significant （P〈0.05）.The mean PS was not statistically significant （P〉0.05）.The mean Qb, Vb, and κps between pancreatitis group and normal group were statistically significant （P〈0.05）. Conclusion： MSCT perfusion imaging provides a new method for the diagnosis of pancreatic diseases, and affords new basis for therapy. Qb, Vb of pancreatic cancer shorten significantly and tmt, κps increase markedly. It is significant that MSCT perfusion imaging analyzes the change of the blood flow for pancreatic carcinoma.