| Facile Conversion of Alcohols to Olefins by Tosylation and Subsequent SiO2-promoted β-elimination |
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| 引用本文： | RUAN Xiaohong SONG Gaopeng ZHANG Yichun LI Yingxia. Facile Conversion of Alcohols to Olefins by Tosylation and Subsequent SiO2-promoted β-elimination[J]. 中国海洋大学学报(英文版), 2007, 6(2): 196-198. DOI: 10.1007/s11802-007-0196-1 |
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| 作者姓名： | RUAN Xiaohong SONG Gaopeng ZHANG Yichun LI Yingxia |
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| 作者单位： | Key Laboratory of Marine Drugs of the Ministry of Education of China, School of Pharmacy, Ocean University of China, Qingdao 266003, P. R. China |
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| 基金项目： | This work is supported by the National Basic Research Program of China （2003CB716400）. |
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| 摘 要： | A convenient and effective procedure was developed for the conversion of alcohol to olefin by tosylation and subsequent β-elimination promoted by silica gel in this study. Treatment of the alcohols with p-toluenesulfonyl chloride in pyridine at 0℃ affords tosylates which undergo β-elimination with silica gel in dichloromethane or chloroform at room temperature, yielding olefinswith high productivity.
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| 关 键 词： | 醇类 石蜡 简易转化 甲苯磺酰基化 β-消去反应 二氧化硫 |
| 收稿时间： | 2006-04-13 |
| 修稿时间： | 2006-11-29 |
Facile conversion of alcohols to olefins by tosylation and subsequent SiO2-promoted β-elimination |
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| Ruan Xiaohong,Song Gaopeng,Zhang Yichun,Li Yingxia. Facile conversion of alcohols to olefins by tosylation and subsequent SiO2-promoted β-elimination[J]. Journal of Ocean University of China, 2007, 6(2): 196-198. DOI: 10.1007/s11802-007-0196-1 |
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| Authors: | Ruan Xiaohong Song Gaopeng Zhang Yichun Li Yingxia |
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| Affiliation: | (1) Key Laboratory of Marine Drugs of the Ministry of Education of China, School of Pharmacy, Ocean University of China, Qingdao, 266003, P. R. China |
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| Abstract: | A convenient and effective procedure was developed for the conversion of alcohol to olefin by tosylation and subsequent β-elimination promoted by silica gel in this study. Treatment of the alcohols with p-toluenesulfonyl chloride in pyridine at 0°C affords tosylates which undergo β-elimination with silica gel in dichloromethane or chloroform at room temperature, yielding olefins with high productivity. |
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| Keywords: | alcohol tosylation silica gel olefin β -elimination |
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