Selenium distribution in the local environment of selected villages of the Keshan Disease belt,Zhangjiakou District,Hebei Province,People's Republic of China |
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| Institution: | 1. Analytical and regional Geochemistry Group, British Geological Survey, Keyworth, Nottingham NG12 5GG, UK;2. Institute of Rock and Mineral Analysis, Chinese Academy of Geological Sciences, Beijing, People''s Republic of China;1. Institute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin University, Geelong, Victoria, Australia;2. Melbourne Dementia Research Centre, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, 30 Royal Parade, 3052, Parkville, Victoria, Australia;3. Department of Medicine, Royal Melbourne Hospital, Melbourne, Victoria, Australia;4. Melbourne School of Psychological Sciences, The University of Melbourne, Parkville, Victoria, Australia;5. Developmental Imaging, Murdoch Children''s Research Institute, Melbourne, Victoria, Australia;6. Departments of Neuroscience and Neurology, The Central Clinical School and The Alfred Hospital, Monash University, Melbourne, Victoria, Australia;7. Department of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia;8. Department of Radiology, Royal Melbourne Hospital, University of Melbourne, Melbourne, Victoria, Australia;9. Centre for Molecular Imaging, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia;10. Eastern Cognitive Disorders Clinic, Department of Neurology, Eastern Health, Monash University, Melbourne, Victoria, Australia;11. Department of Clinical Neurosciences and Neurological Research, St Vincent''s Hospital, Fitzroy, Victoria, Australia;12. Caulfield Hospital, Alfred Health, Caulfield, Victoria, Australia;13. Department of Surgery, Royal Melbourne Hospital, Melbourne, Victoria, Australia;14. Department of Psychiatry, The University of Melbourne, Parkville, Victoria, Australia;1. 2nd Department of Cardiology and Cardiovascular Interventions, University Hospital, Cracow, Poland;2. Department of Clinical Rehabilitation, University of Physical Education, Cracow, Poland;3. Unit of Rehabilitation in Internal Diseases, Institute of Physiotherapy, Faculty of Health Sciences, Jagiellonian University School of Medicine, Cracow, Poland;4. Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland;5. Jagiellonian Center for Experimental Therapeutics, Jagiellonian University, Cracow, Poland;6. Department of Internal Medicine, Jagiellonian University School of Medicine, Cracow, Poland |
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| Abstract: | The distribution of Se in cultivated topsoils, grains, human hair and drinking water has been studied in 15 villages from a Keshan disease area of the People's Republic of China, villages being classified into 3 groups according to the Keshan disease incidence in the local population. In grain, hair and water the total Se follows expected trends; i.e. the highest concentrations are found in the villages where there is no incidence of Keshan disease. However, the soils from the high-incidence Keshan disease villages have the highest total Se content, an apparent contradiction, as Keshan disease is a response to a Se deficient environment. Soil analyses suggest that the organic content of the soils is a major factor in controlling the availability of Se and it is the high-incidence Keshan disease villages that have the most organic-rich soils. Although higher in total Se, the organic-rich soils have little bioavailable Se resulting in a Se deficient food chain. Soil pH is also seen to be a related factor in restricting the availability of Se and all the grain samples collected on soils with a pH <7.6 had a total Se content of less than 10% of the total soil Se. In an environment that can be classified as Se deficient small changes in the soil organic content and pH can have a critical affect on the Keshan disease status of a village. |
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