| Abstract: | Pyropia haitanensis poly saccharide(LP) have been found for having many excellent functions such as anti-aging.Using Caenorhabditis elegans models,we evaluated the anti-aging activity of LP by observing the lifespan,reproduction,pharyngeal pumping,stress response,quantitative fluorescence of poly glutamic acid,and nuclear localization of DAP-16 of worms.The results reveal that LP could extend the adult lifespan of wild-type and polyQ nematodes,indicating a connection of its anti-aging benefit with the toxicity-suppressing effect The number of polyglutamic acid aggregates in high concentration groups decreased by 24.39%(P0.05) to the control.The high-dose group strongly induced DAP-16 nuclear translocation over intermediate and cytosolic localizations compared with the control(P0.001).Therefore,we believe that LP could extend the lifespan and reduce the protein aggregation in C.elegans through nuclear DAF-16::GFP expression. |
