海洋真菌来源吲哚生物碱类化合物的结构和活性研究

近年来，海洋真菌因其能够产生大量结构新颖、活性显著的代谢产物而受到广泛关注。本文综述了1991?2010年间从海洋真菌分离得到的134个新吲哚生物碱的结构和活性研究情况，其中包括fumitremorgin类19个、notoamide类22个、细胞松弛素类18个、吲哚喹唑啉类9个、吲哚萜类11个、肽类及其他单吲哚类21个和双吲哚类化合物34个。海洋真菌来源的吲哚生物碱不仅结构奇特，并且表现出多种重要的生物活性，具有潜在的研究和应用价值。

Indole alkaloids from marine-derived fungi: structures and activities

In recent years, marine natural products of fungal origin have gained considerable recognition, as many of them possess novel structures and interesting biological and pharmacological properties. This review includes 134 indole alkaloids of marine-derived fungi with their structures and activities published during 1991-2010. Of the indole alkaloids, there were 19 fumitremorgins, 22 notoamides, 18 cytochalasans, 9 fumiquinazolines, 11 indole terpenes, 21 peptides and other single indole alkaloids, and 34 bisindole alkaloids. These indole alkaloids showed not only unique structures but also a variety of important biological activities and had potential values in application.