Effects of polypeptide from<Emphasis Type="Italic">Chlamys farreri</Emphasis> on amino acid content in guinea pig skin irradiated by chronic ultraviolet A and B |
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Authors: | Yu?Guoying Cao?Pengli Guo?Kun Wang?Yuejun Sun?Mi Email author" target="_blank">Wang?ChunboEmail author |
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Institution: | (1) Affiliated Hospital of Medical College, Qingdao University, 266003 Qingdao, China;(2) Department of Pharmacology, Medical College, Qingdao University, 266021 Qingdao, China |
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Abstract: | We examined the effects of polypeptide fromChlamys farreri (PCF) on the amount of hydroxyproline in guinea pig skin irradiated by chronic ultraviolet A (UVA) and ultraviolet B (UVB)
radiation. PCF was applied locally before repeated exposure of guinea pig to UVA and UVB. The contents of hydroxyproline and
other amino acids in guinea pig skin were determined by automatic amino acid analyzer. Our results showed that: (1) long-time
UVA and UVB radiation can reduce dramatically the amounts of hydroxyproline, aspartic acid, threonine, glycine, phenylalanine
and lysine in guinea pig skin in comparison with the control group (P<0.05); (2) Compared with model group, pre-treatment with 5% and 20% PCF prior to UVA and UVB radiation can inhibit the decline
of amino acids content in guinea pig skin in a dose-dependent manner (P<0.05). As the decrease of hydroxyproline, glycine and lysine contents in the skin directly reflexes type I collagen degeneration,
our results indicated that the chronic application of PCF can protect skin type I collagen against UV radiation, and thus
protect skin from photoaging.
Project No. 39970638 supported by the NSFC, and also supported by the Science and Technology Bureau of Qingdao (No: 2001-28-50). |
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Keywords: | polypeptide fromChlamys farreri ultraviolet radiation hydroxyproline photoaging guinea pig |
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