| Immunosuppressive Activities of Fucoidan from Laminaria japonica |
| |
| 作者姓名： | 张全斌 李智恩 周革非 牛锡珍 张虹 |
| |
| 作者单位： | InstituteofOceanology,ChineseAcademyofSciences,Qingdao266071,China |
| |
| 基金项目： | ThisstudywassupportedbyNationalFoundationforNewDrugResearch&Development (NFND)No .1 4 4. |
| |
| 摘 要： | Effects of fucoidan from Laminariajaponica on 2,4-dinitrochlorobenzene induced de-layed-type hypersensitivity (DTH) reaction and the serum levels of IgG, IgM, complement C3 and C4 were investigated in the present study. Results showed that oral administration of fucoidan atdose of 1.50 and 300 mg/(kg*d) for 9 days before the hapten challenge significantly inhibited 2,4-dinitrochlorobenzene induced delayed-type hypersensitivity reaction; and also inhibited the humoral immunity. Serum C3 and C4 levels were markedly reduced by fucoidan at dose of 1.50 and 300 mg/kg; and serum IgG and IgM levels were reduced by fucoidan at dose of 300 mg/kg. The inhibitory effects of fucoidan on delayed-type hypersensitivity suggested that it may be potential medication for chronic inflammatory diseases in the future.
|
| 关 键 词： | 免抑制疫力 放射性 岩藻依聚糖 昆布属植物 |
Immunosuppressive Activities of Fucoidan from Laminaria japonica |
| |
| Abstract: | Effects of fucoidan from Laminaria japonica on 2,4-dinitrochlorobenzene induced delayed-type hypersensitivity (DTH) reaction and the serum levels of IgG, IgM, complement C3 and C4 were investigated in the present study. Results showed that oral administration of fucoidan at dose of 150 and 300 mg/(kg*d) for 9 days before the hapten challenge significantly inhibited 2,4-dinitrochlorobenzene induced delayed-type hypersensitivity reaction; and also inhibited the humoral immunity. Serum C3 and C4 levels were markedly reduced by fucoidan at dose of 150 and 300 mg/kg; and serum IgG and IgM levels were reduced by fucoidan at dose of 300 mg/kg. The inhibitory effects of fucoidan on delayed-type hypersensitivity suggested that it may be potential medication for chronic inflammatory diseases in the future. |
| |
| Keywords: | Laminaria japonica fucoidan delayed type hypersensitivity humoral immunity |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
