Behavioral effects of titanium dioxide nanoparticles on larval zebrafish (Danio rerio) |
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| Institution: | 1. Shenzhen Key Laboratory of Organia Pollution Prevention and Control, State Key Laboratory of Urban Water Resource and Environment of Harbin Institute of Technology (Shenzhen), 518055, China;2. Tianjin Key Laboratory of Marine Resources and Chemistry, College of Marine and Environmental Sciences, Tianjin University of Science and Technology, Tianjin, China;3. Graduate School at Shenzhen, Tsinghua University, Shenzhen, China |
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| Abstract: | In this study, zebrafish embryos were exposed to titanium dioxide nanoparticles (TiO2 NPs at 0.1, 0.5, 1, 5, 10 mg/L or control) from fertilization to free swimming stage. Hatchability, survival, and malformation rate were not affected by TiO2 NPs at these exposure levels. However, larval swimming parameters, including average and maximum velocity and activity level were significantly affected by TiO2 NPs. Co-exposure to either the glutathione precursor, N-acetylcysteine (NAC), or the glutathione synthesis inhibitor, buthionine sulfoximine (BSO), did not significantly alter the behavioral effects resulting from TiO2 NPs, suggesting that other factor(s) besides oxidative stress may contribute to the behavioral toxicity of TiO2 NPs. Our study also demonstrated that the behavioral endpoints were more sensitive than the others (e.g., hatchability and survival) to detect toxicity of TiO2 NPs on developing fish. |
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