Molecular staging of marine medaka: A model organism for marine ecotoxicity study |
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| Institution: | 1. State Key Laboratory in Marine Pollution, Department of Biology and Chemistry, City University of Hong Kong, Tat Chee Avenue, Hong Kong;2. Department of Biology, Ghent University, Ledeganckstraat 35, B-9000 Ghent, Belgium;3. Institute for Advancing Translational Medicine in Bone & Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong;4. Shenzhen Key Laboratory for the Sustainable Use of Marine Biodiversity, Research Centre for the Oceans and Human Health, City University of Hong Kong, Shenzhen Research Institute, Shenzhen 518057, China;1. Department of Biological Science, College of Science, Sungkyunkwan University, Suwon 440-746, South Korea;2. National Instrumentation Center for Environmental Management, College of Agriculture and Life Sciences, Seoul National University, Seoul 151-921, South Korea;3. Department of Marine Science, College of Natural Sciences, Incheon National University, Incheon 406-772, South Korea;4. State Key Laboratory on Marine Pollution, City University of Hong Kong, Kowloon, Hong Kong, China;5. School of Biological Sciences, University of Hong Kong, Hong Kong SAR, China;1. State Key Laboratory of Marine Environmental Science, Xiamen University, Xiamen 361102, China;2. Key Laboratory of the Ministry of Education for Coastal and Wetland Ecosystems, Xiamen University, Xiamen 361102, China;3. College of the Environment and Ecology, Xiamen University, Xiamen 361102, China |
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| Abstract: | Oryzias melastigma, also called O. dancena, is becoming a very useful model for estuarine and marine ecotoxicity studies. With O. melastigma being adopted by ILSI Health and Environmental Science Institute (HESI) for embryo toxicity testing, improved knowledge of biomarker based embryonic development becomes especially important for mechanism-based toxicity evaluations. Using whole mount in situ hybridization and immunostaining techniques together with widely used molecular markers, this study describes the molecular development of marine medaka embryos, focusing on the brain, eye, heart, pectoral fin, pancreas, liver, muscle and neuron system. These organs are targets of environmental pollutants that disrupt normal embryonic development in medaka and other fish. |
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