DTI及SWI在早期原发性帕金森病患者脑黑质改变中的应用研究

目的:探讨磁共振扩散张量成像（DTI）及磁敏感加权成像（SWI）在早期原发性帕金森病（PD）患者脑黑质改变中的应用价值。方法:采用3.0 T磁共振成像系统对早期原发性PD患者组及正常对照组进行常规序列、DTI及SWI序列扫描，其中原发性早期PD患者13例，正常对照组13例。测量两组间脑黑质的FA值、ADC值及黑质致密带大小。结果:两组间双侧黑质的FA值比较，PD组较对照组减低，差异有统计学意义（P<0.05）。两组间黑质ADC值比较，差异无统计学意义P>0.05）。PD组黑质致密带大小较对照组减小，差异有统计学意义（P<0.05）。结论:黑质的FA值及黑质致密带大小有助于PD的早期诊断，DTI与SWI具有协同作用，可为PD的早期诊断提供有价值的线索。 

The Application of DTI and SWI for Substantia Nigra in Early Primary Parkinson's Disease

Objective: To investigate the application of diffusion tensor imaging (DTI) and susceptibility weighted imaging (SWI) in the changes of substantia nigra in patients with early primary Parkinson's disease. Methods: Conventional sequence, DTI, and SWI scans were performed on 13 patients with early primary Parkinson's disease and 13 volunteers as controls using a 3 T magnetic resonance imaging system. The FA and ADC values of the substantia nigra of the two groups and the size of the substantia nigra pars compacta were measured. Results: The FA values of bilateral substantia nigra were reduced in the PD group compared with the control group, the difference was statistically meaning (P<0.05). There was no significant difference in the ADC values of the substantia nigra between the two groups (P>0.05). The size of the substantia nigra pars compact in the PD group was smaller than that in the control group, the difference was statistically meaning (P<0.05). Conclusions: The FA value of the substantia nigra and the size of the substantia nigra pars compacta contribute to the early diagnosis of PD. DTI and SWI have a synergistic effect and may provide valuable clues for the early diagnosis of PD.