昆布寡糖对2型糖尿病大鼠的实验作用

从沿海藻类昆布(Thallus laminariae)中提取昆布多糖,经降解后得昆布寡糖。采用高脂饲料加小剂量链脲佐菌素法诱导SD大鼠2型糖尿病动物模型,成模后大鼠分为正常对照组,阴性对照组,二甲双胍组,昆布寡糖高、中、低剂量组,灌胃给予寡糖溶液8周,定期观察体重并采集血液标本进行检测。结果表明,昆布寡糖对糖尿病大鼠有明显的降低血糖,升高胰岛素,增加体重,降低甘油三酯、总胆固醇、游离脂肪酸,升高高密度脂蛋白胆固醇的作用,但对低密度脂蛋白胆固醇的影响不明显。可见,昆布寡糖对2型糖尿病大鼠具有明显治疗作用。

Antidiabetic Effect of Thallus laminariae Oligosaccharide on Type 2 Diabetic Rats

Thallus laminariae oligosaccharide was extracted and cut from Thallus laminariae.High-fat chow and streptozotocin were used to induce type 2 diabetc animal model of rat,then rats were divided into six groups: Normal group,Negative control group,Dimethylbiguanide group,High-dose group,Middle-dose group and Low-dose group,Thallus laminariae oligosaccharide solution was orally administered for 8 weeks,and body weight and blood were collected and detected.Results are as follows: Significant decreases in blood glucose,triglyceride,total cholesterol,free fatty acids and significant increases in body weight,insulin level,HDL-C were detected in oligosaccharide-treated rats compared with negative control group rats,but the effect on LDL-C was not significant.These results indicated that Thallus laminariae oligosaccharide has significant therapeutic effect on type 2 diabetic rats.