| 异枝麒麟菜硫酸多糖的降解及其对尿石矿物草酸钙的抑制作用 |
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| 引用本文： | 王 淼,于海燕,欧阳健明. 异枝麒麟菜硫酸多糖的降解及其对尿石矿物草酸钙的抑制作用[J]. 海洋科学, 2008, 32(8): 34-37 |
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| 作者姓名： | 王 淼 于海燕 欧阳健明 |
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| 作者单位： | 暨南大学,生物矿化与结石病防治研究所,广东,广州,510632;暨南大学,生物矿化与结石病防治研究所,广东,广州,510632;暨南大学,生物矿化与结石病防治研究所,广东,广州,510632 |
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| 基金项目： | 广东省科技攻关计划，国家自然科学基金，国家自然科学基金 |
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| 摘 要： | 采用过氧化氢法降解了相对分子质量约为141万±8.3万的海藻异枝麒麟菜(Eucheuma striatum Schmitz)硫酸多糖(ESPS),降解产物平均相对分子质量为4 819±440.降解后多糖的硫酸基(OSO2-3)质量分数稍有下降,由16.03%降至15.20%左右.同时,用体外模拟方法研究了降解前后ESPS对草酸钙(CaOxa)晶体生长的抑制作用,降解后的ESPS明显优于未降解多糖,其诱导生成的一水草酸钙(COM)晶体尺寸进一步减小,晶体数量减少,且棱角更为圆钝.表明低分子质量ESPS更能抑制CaOxa晶体的成核和生长.
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| 关 键 词： | 异枝麒麟菜(Eucheuma striatum Schmitz)多糖 降解 草酸钙 尿结石 |
| 收稿时间： | 2007-08-28 |
| 修稿时间： | 2008-02-29 |
Degradation of sulfated polysaccharide from Eucheuma striatum and its inhibition on urinary mineral calcium oxalate |
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| WANG Miao,YU Hai-yan,OUYANG Jian-ming. Degradation of sulfated polysaccharide from Eucheuma striatum and its inhibition on urinary mineral calcium oxalate[J]. Marine Sciences, 2008, 32(8): 34-37 |
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| Authors: | WANG Miao YU Hai-yan OUYANG Jian-ming |
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| Affiliation: | WANG Miao,YU Hai-yan,OUYANG Jian-ming (Institute of Biomineralization , Lithiasis Research,Jinan University,Guangzhou 510632,China) |
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| Abstract: | Algal Eucheuma striatum sulfated polysaccharide was degraded by hydrogen peroxide (H2O2) from average molecular weight of 1 410 000 ±83 000 to 4 819 ±440 or so. The mass fraction (w) of sulfate group (OSO2-3) decreased from 16.03% to 15.20%. The effects of ESPS before and after degradation on crystal growth of calcium oxalate (CaOxa) were investigated in vitro. The size and number of CaOxa crystals induced by degraded ESPS were much smaller than those of the undegraded polysaccharide, and the edges and angles of the former were much rounder and blunter. That is, the ESPS with a low molecular weight could more inhibit the nucleation and growth of CaOxa crystals. |
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| Keywords: | Eucheuma striatum polysaccharide degradation calcium oxalate urinary stones |
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