基于生物信息学探讨骨质疏松症与2型糖尿病的关系

目的：基于生物信息学探讨骨质疏松症与 2 型糖尿病的关系。方法：通过基因表达汇编（GEO）数据库检索骨质疏松症和2型糖尿病的相关数据集,并筛选骨质疏松症-2型糖尿病共同差异表达基因,将数据导入STRING数据库找寻关键基因,以一个单细胞测序数据集作为检验集验证关键基因细胞层面的表达水平,对筛选结果进行基因本体（GO）功能及京都基因与基因组百科全书（KEGG）通路富集分析,并对关键靶点、相关中药进行频数统计及功效分类。结果：骨质疏松症与 2 型糖尿病相关通路集中在 ErbB信号通路、丝活化蛋白激酶（MAPK）信号通路、神经营养素信号通路、NOD样受体信号通路。频数统计结果显示,与骨质疏松症-2型糖尿病关键基因相关的中药有51味,以功效分类,可分为清热解毒药、止痛药、祛风药、补虚药、止呕药。结论：骨质疏松症和2型糖尿病都是复杂的代谢性疾病,涉及众多基因表达网络和信号通路。尽管两种疾病存在复杂的基因网络背景,但是分析结果表明两种疾病之间仍存在高度重合的差异基因表达和信号通路。这表明两种疾病的分子机制密切相关,可能存在共同调控的靶点,因此这些靶点可能成为药物同时干预两种疾病的治疗靶点。     

大鹏湾潮流数值计算

应用分步杂交方法建立了大鹏湾边界潮流数值模型，并对其进行了模拟计算，重现了该区域潮波及潮流的分布规律，并根据实测资料对其进行了验证，从而可系统地了解这一海区的潮波系统及潮流场等海洋要素的分布情况。     

太湖表面定振波的数值计算和最大熵谱分析

利用水动力学方程对太湖表面的定振波进行计算，算得定振波周期约为４５２ｍｉｎ，另外，利用１９９２年８月２９－３１日在太湖西山观测到的水位资料，采用最大熵谱法，分析太湖表面的定振波，得周期值约为４５０ｍｉｎ。计算和分析的周期值基本吻合，取熵谱分析结果得太湖表面的单节点定振波周期值为４５０ｍｉｎ。     

北部湾三维潮流场数值研究(英文)

本文对北部湾三维潮波进行了数值研究,并将所得结果与现有观测资料作了比较。通过比较发现两者相当一致。文中还绘制了M_2和K_1分潮的同潮图,并对其作了讨论。可以断定,北部湾的日潮优势是由日潮共振所引起的。M_2和K_1分潮流的水平分布表明,强流区位于它们各自的蜕化无潮点附近。还讨论了分潮流的铅直结构,可以看出这种结构十分接近实际分潮流场的特征。     

分潮波模型多资料数值计算方法研究 Ⅱ.有限差分最小二乘方法

对含多资料的分潮波模型的超定问题进行探讨，建立一种有限差分—最小二乘方法，该方法使得岸边资料直接进入了计算方程，并保证岸界法向流速为零条件。通过对渤海的四大分潮的试算，证实本方法可行。     

南海北部主要经济鱼类体长与体重关系

文中根据1997～1999年和2001～2002年期间在南海北部底拖网调查的43种共33 389尾鱼的体长（叉长、肛长）和体重数据,应用统计分析方法对各鱼种体长与体重关系进行分析.结果表明,43种鱼分别隶属于4目16科25属,相关系数R^2的范围为0.764～0.993,相关系数R^2值相对较高,其中58%的R^2值超过0.95.幂指数b值范围为2.50～3.44,平均2.90.盒须图分析表明,50%的b值在2.79～3.01范围.经初步分析,43种主要经济鱼类中,有16种为等速生长、22种负的异速生长和5种正的异速生长.     

Study on copper complexing ligand concentrations in several China’s coastal waters

Copper complexing ligand concentrations in the Daya Bay, Qingdao coast, Jiaozhou Bay, South China Sea and Huanghe Estuary waters were determined by the anodic stripping voltammetry technique. The distribution regularity and the relationship with other parameters were discussed. The results were as follows: Copper complexing ligand concentrations of the South China Sea were a little higher than those of other sea areas, and they were apparently higher than those of the ocean. Compared with the subsurface layer (SSL) in the sea surface microlayer copper complexing ligand concentrations showed an enrichment phenomenon, of which the mechanism is similar to dissolved organic matter. The metal complexing ligand concentration profiles of the South China Sea showed that the value in the sea surface was the highest, then it decreased with depth accruing, and a higher value appeared at the bottom. Copper complexing ligand concentrations were higher than those of cadmium and lead. Ligands in each sea area exhibited a complicated property. In short, the distribution regularity of copper complexing ligand concentrations in China' s coastal waters was consistent with that of other regions in the world. Meanwhile, the positive relationship between the copper complexing ligand concentrations and biological oxygen demand, chemical oxygen demand, dissolved organic carbon, and viscosity were found clearly.     

受陆岸影响浅水区台风风浪的计算方案

在我国港口工程技术规范的波浪成长理论基础上，考虑到台风波浪的基本特点、等效水深的概念、浅水区波浪的折射、不规则波的能量分布特性、受陆岸和岛屿影响角度范围内的有效能量风区长度等因素，提出了受陆岸、岛屿影响浅水区（包括海湾区）台风风浪的计算方案。本方案只需台风中心位置、中心气压和计算点于各方位的风区长度（受陆岸影响部分）等资料，便可快速地得到计算点的波浪要素。经实测资料验证，效果良好。     

Influence of Approach Channel on Wave Propagation with Varying Incident Angles

- The variation of the amplitude of waves with varying incident angles when waves propagate through a typical approach channel is discussed by a numerical calculation method, the result of which shows that the influence of the channel on wave propagation is obvious. When the wave propagation direction is in coincidence with the channel axis, the wave amplitude ratio will decrease with the increase of propagation distance. When the incident angle is 15 - 30 , there appears an area of larger wave amplitude ratio on the side slope facing the waves, but at the another side, the wave amplitude ratio is generally small, indicating that the channel has a shielding effect. When waves propagate across the channel perpendicularly, the wave amplitude ratio can be calculated with the shallow water coefficient.