P‐wave transmission across fractures with nonlinear deformational behaviour

Stress wave attenuation across fractured rock masses is a great concern of underground structure safety. When the wave amplitude is large, fractures experience nonlinear deformation during the wave propagation. This paper presents a study on normal transmission of P‐wave across parallel fractures with nonlinear deformational behaviour (static Barton–Bandis model). The results show that the magnitude of transmission coefficient is a function of incident wave amplitude, nondimensional fracture spacing and number of fractures. Two important indices of nondimensional fracture spacing are identified, and they divide the area of nondimensional fracture spacing into three parts (individual fracture area, transition area and small spacing area). In the different areas, the magnitude of transmission coefficient has different trends with nondimensional fracture spacing and number of fractures. In addition, the study reveals that under some circumstances, the magnitude of transmission coefficient increases with increasing number of fractures, and is larger than 1. Copyright © 2006 John Wiley & Sons, Ltd.     

Freely floating-body simulation by a 2D fully nonlinear numerical wave tank

Nonlinear interactions between large waves and freely floating bodies are investigated by a 2D fully nonlinear numerical wave tank (NWT). The fully nonlinear 2D NWT is developed based on the potential theory, MEL/material-node time-marching approach, and boundary element method (BEM). A robust and stable 4th-order Runge–Kutta fully updated time-integration scheme is used with regriding (every time step) and smoothing (every five steps). A special φ_n-η type numerical beach on the free surface is developed to minimize wave reflection from end-wall and wave maker. The acceleration-potential formulation and direct mode-decomposition method are used for calculating the time derivative of velocity potential. The indirect mode-decomposition method is also independently developed for cross-checking. The present fully nonlinear simulations for a 2D freely floating barge are compared with the corresponding linear results, Nojiri and Murayama’s (Trans. West-Jpn. Soc. Nav. Archit. 51 (1975)) experimental results, and Tanizawa and Minami’s (Abstract for the 6th Symposium on Nonlinear and Free-surface Flow, 1998) fully nonlinear simulation results. It is shown that the fully nonlinear results converge to the corresponding linear results as incident wave heights decrease. A noticeable discrepancy between linear and fully nonlinear simulations is observed near the resonance area, where the second and third harmonic sway forces are even bigger than the first harmonic component causing highly nonlinear features in sway time series. The surprisingly large second harmonic heave forces in short waves are also successfully reproduced. The fully updated time-marching scheme is found to be much more robust than the frozen-coefficient method in fully nonlinear simulations with floating bodies. To compare the role of free-surface and body-surface nonlinearities, the body-nonlinear-only case with linearized free-surface condition was separately developed and simulated.     

基于网络药理学探究补阳还五汤治疗颈椎病的作用机制

目的：基于网络药理学与分子对接技术分析补阳还五汤治疗颈椎病的作用机制。方法：使用TCMSP、化学专业数据库获取补阳还五汤的活性成分,并对潜在靶点进行预测及规范。分别从PharmGKB、DisGeNET、OMIM、GeneCards数据库中得到颈椎病疾病靶点,利用韦恩图获取补阳还五汤与颈椎病的交集靶点。通过CytoScape软件构建中药-活性成分-疾病靶点和蛋白质-蛋白质相互作用（PPI）网络,获得核心有效成分与关键靶点,利用David数据库对潜在靶点进行富集分析。最后运用AutoDock Vina软件对补阳还五汤核心有效成分与关键靶点进行分子对接验证。结果：共获得补阳还五汤治疗颈椎病的有效活性成分97个,包括槲皮素、山柰酚、黄芩素、木犀草素等;交集靶点64个,关键靶点有白细胞介素-6（IL-6）、肿瘤坏死因子（TNF）、丝氨酸/苏氨酸蛋白激酶1（AKT1）、白细胞介素-1B（IL-1B）等;主要涉及肿瘤坏死因子（TNF）、白细胞介素-17（IL-17）、磷脂酰肌醇3-激酶（PI3K）/蛋白激酶B（Akt）等信号通路,分子对接结果显示核心有效成分与关键靶点之间结合紧密,为补阳还五汤治疗颈椎病提供相应条件。结论：该研究在总体上预测了补阳还五汤治疗颈椎病的活性成分、靶点和信号通路,作用途径广泛,为下一步的临床应用提供参考及思路。     

Variational iteration solving method for El Nio phenomenon atmospheric physics of nonlinear model

1 IntroductionThe El Ni’o atmospheric physics oscillation is anabnormal phenomenon involved in the tropical Pacificocean- atmosphere interactions. Studies on the El Ni(ophenomenon are very attractive (Lin et al., 2000; Linet al., 2001, 2002; Wang, 2001; Feng et al., 2001;Feng et al., 2002; Liu et al., 2002; Wei and Chen,2003; Xie et al., 2002; Zhu et al., 2002; Pu et al.,2003; Gu et al., 2004; Yu and Liu, 2004). Lin and Mo(2004), Mo and Lin (2004) and Mo et al. (2004) alsostudied a s…     

Fully nonlinear numerical wave tank (NWT) simulations and wave run-up prediction around 3-D structures

A finite-difference scheme and a modified marker-and-cell (MAC) algorithm have been developed to investigate the interactions of fully nonlinear waves with two- or three-dimensional structures of arbitrary shape. The Navier–Stokes (NS) and continuity equations are solved in the computational domain and the boundary values are updated at each time step by the finite-difference time-marching scheme in the framework of a rectangular coordinate system. The fully nonlinear kinematic free-surface condition is implemented by the marker-density function (MDF) technique developed for two fluid layers.To demonstrate the capability and accuracy of the present method, the numerical simulation of backstep flows with free-surface, and the numerical tests of the MDF technique with limit functions are conducted. The 3D program was then applied to nonlinear wave interactions with conical gravity platforms of circular and octagonal cross-sections. The numerical prediction of maximum wave run-up on arctic structures is compared with the prediction of the Shore Protection Manual (SPM) method and those of linear and second-order diffraction analyses based on potential theory and boundary element method (BEM). Through this comparison, the effects of non-linearity and viscosity on wave loading and run-up are discussed.     

基于网络药理学与分子对接技术探讨青蛇方外用治疗湿疹的作用机制

目的：基于网络药理学与分子对接技术探讨青蛇方外用治疗湿疹的作用机制。方法：应用TCMSP和UniProt数据库平台查询青蛇方组方的有效活性成分及靶基因,与疾病靶基因取交集后构建蛋白质-蛋白质相互作用(PPI)网络;应用DAVID数据库,对潜在核心作用靶点基因进行基因本体（GO）功能、京都基因与基因组百科全书（KEGG）通路富集分析。利用分子对接原理论证青蛇方生物活性成分与核心靶点的分子结合能力。结果：筛选出青蛇方有效成分63种,作用靶点99个;主要有β-谷甾醇、2,4,7-三羟基-9,10-二氢菲、靛蓝素、豆甾醇、色氨酸等关键成分;转录因子AP-1（JUN）、肿瘤坏死因子（TNF）、原癌基因（RELA）、干扰素γ（IFNG）、转化生长因子-β1（TGF-β1）等核心基因。关键信号通路有癌症信号通路、恰加斯病通路、弓形体病通路、脂质和动脉粥样硬化通路等,分子对接结果显示活性成分与核心靶点基因结合能力较强。结论：青蛇方外用可以通过多种活性成分、多种通路有效抑制免疫炎症反应,促进免疫系统正常运行,从而达到治疗湿疹的目的。     

Semi-analytical solutions of a contaminant transport equation with nonlinear sorption in 1D

A new method to determine semi-analytical solutions of one-dimensional contaminant transport problem with nonlinear sorption is described. This method is based on operator splitting approach where the convective transport is solved exactly and the diffusive transport by finite volume method. The exact solutions for all sorption isotherms of Freundlich and Langmuir type are presented for the case of piecewise constant initial profile and zero diffusion. Very precise numerical results for transport with small diffusion can be obtained even for larger time steps (e.g., when the Courant-Friedrichs-Lewy (CFL) condition failed).     

山西沁水盆地煤层气成藏的微观动力能条件研究

煤层气成藏的微观动力能条件主要包括煤储层的孔隙—裂隙系统、煤储层的生气作用和储气作用两个方面。以山西沁水盆地为例,深入剖析了煤储层的孔隙—裂隙系统及其发育历程、煤储层的生气作用与能量聚散,阐明了煤层气成藏的微观动力能对成藏效应的控制作用。结果表明:构造作用对储层渗透率具有明显的控制作用,成烃增压致使能量聚集,成为盖层突破作用的主要驱动力,而能量放散则主要是通过煤储层孔隙—裂隙系统的产生、发展。根据上述研究成果,沁水盆地煤层气成藏的地质区划结果为:盆地南部的有利区带为阳城和晋城的北部地区,包括潘庄、樊庄、郑庄等地区;盆地中部的有利区带为安泽—沁源地区,位于盆地西斜坡的中南部;盆地北部的可能有利区带为寿阳东南部地区,位于榆次东北部和阳泉西南部之间。     

有限弹性变形地壳中的地震波

地壳由半无限大的基岩上一层厚度为H^-的表土层组成，入射地震波为垂直的SH波，产生水平地面运动。当浅源大地震发生时，在极震区以外行波传播产生地面运动将使地壳介质有非线性的有限弹性变形。用小参数摄动法使非线性控制方程为线性化的小参数各阶控制方程，得出头两阶线性控制方程的解析解。     

Development of site-specific design ground motions in Western and Eastern North America

This paper presents results recently obtained for generating site-specific ground motions needed for design of critical facilities. The general approach followed in developing these ground motions using either deterministic or probabilistic criteria is specification of motions for rock outcrop or very firm soil conditions followed by adjustments for site-specific conditions. Central issues in this process include development of appropriate attenuation relations and their uncertainties, differences in expected motions between Western and Eastern North America, and incorporation of site-specific adjustments that maintain the same hazard level as the control motions, while incorporating uncertainties in local dynamic material properties. For tectonically active regions, such as the Western United States (WUS), sufficient strong motion data exist to constrain empirical attenuation relations for M up to about 7 and for distances greater than about 10–15 km. Motions for larger magnitudes and closer distances are largely driven by extrapolations of empirical relations and uncertainties need to be substantially increased for these cases.

For the Eastern United States (CEUS), due to the paucity of strong motion data for cratonic regions worldwide, estimation of strong ground motions for engineering design is based entirely on calibrated models. The models are usually calibrated and validated in the WUS where sufficient strong motion data are available and then recalibrated for applications to the CEUS. Recalibration generally entails revising parameters based on available CEUS ground motion data as well as indirect inferences through intensity observations. Known differences in model parameters such as crustal structure between WUS and CEUS are generally accommodated as well. These procedures are examined and discussed.