Tephrochronology and tephrostratigraphy of two Pleistocene continental fossiliferous successions from central Italy

The stratigraphical context of two Middle Pleistocene fossiliferous palaeosols from Central Italy (Abruzzo and Tuscany) have been studied. Small mammals and molluscs occur in both palaeosols, which are covered by tephra layers that were analysed using an interdisciplinary approach. Application of fission‐track dating to apatites separated from the Case Picconetto tephra (Pescara, Abruzzo), yielded an age of 0.48 ± 0.04 Ma, indistinguishable from those previously determined for the Campani Quarry (Lower Valdarno, Tuscany) (0.46 ± 0.05 Ma and 0.48 ± 0.05 Ma). Geochemical and petrographic investigations indicate that these tephra originated from different volcanoes, the Alban Hills Volcanic Complex and the Vico Volcano (Latium) respectively. Small mammal and mollusc assemblages indicate different palaeoclimatic and palaeoenvironmental conditions for the Case Picconetto and Campani Quarry palaeosols. Warm and humid conditions can be inferred for the Campani Quarry site, whereas open and cold conditions can be inferred for Case Picconetto. On the basis of faunal data, fission‐track dates and attribution of tephra to specific volcanic eruptions, we suggest a correlation of these faunas with marine oxygen isotope stage 14 (Case Picconetto) and with marine oxygen isotope stage 11 (Campani Quarry), respectively. Copyright © 2003 John Wiley & Sons, Ltd.     

Sea‐surface temperature and salinity changes in the northwest Pacific since the Last Glacial Maximum

The oxygen isotope records of both benthic and planktonic Foraminifera in five piston cores, collected from the region between the Oyashio and Kuroshio Currents near Japan, clearly show the marked latitudinal shifts of these two currents during the past 25 kyr. Under the present hydrographic condition, a clear relationship between the sea‐surface temperature (SST) and oxygen isotope differences from benthic to planktonic Foraminifera is observed in this region. Using this relationship, we find decreased SSTs of 12–13°C (maximum 15°C) in the southernmost core site at the Last Glacial Maximum (LGM), indicating the Oyashio Current shifted southward. The SSTs at the southern two core sites abruptly increased more than 10°C at 10–11 ka, suggesting the Kuroshio Current shifted northward over these sites at 10–11 ka. In contrast, the northern two core sites have remained under the influence of the cold Oyashio Current for the past 25 kyr. With the reasonable estimate of bottom‐water temperature decrease of 2.5°C at the LGM, the SSTs estimated by this new method give exactly the same SST values calculated from Mg/Ca ratio of planktonic Foraminifera, allowing palaeosea‐surface salinities to be reconstructed. The result suggests that the ice volume effect was 1.0 ± 0.1‰ at the LGM. Copyright © 2004 John Wiley & Sons, Ltd.     

基于生物信息学探讨骨质疏松症与2型糖尿病的关系

目的：基于生物信息学探讨骨质疏松症与 2 型糖尿病的关系。方法：通过基因表达汇编（GEO）数据库检索骨质疏松症和2型糖尿病的相关数据集,并筛选骨质疏松症-2型糖尿病共同差异表达基因,将数据导入STRING数据库找寻关键基因,以一个单细胞测序数据集作为检验集验证关键基因细胞层面的表达水平,对筛选结果进行基因本体（GO）功能及京都基因与基因组百科全书（KEGG）通路富集分析,并对关键靶点、相关中药进行频数统计及功效分类。结果：骨质疏松症与 2 型糖尿病相关通路集中在 ErbB信号通路、丝活化蛋白激酶（MAPK）信号通路、神经营养素信号通路、NOD样受体信号通路。频数统计结果显示,与骨质疏松症-2型糖尿病关键基因相关的中药有51味,以功效分类,可分为清热解毒药、止痛药、祛风药、补虚药、止呕药。结论：骨质疏松症和2型糖尿病都是复杂的代谢性疾病,涉及众多基因表达网络和信号通路。尽管两种疾病存在复杂的基因网络背景,但是分析结果表明两种疾病之间仍存在高度重合的差异基因表达和信号通路。这表明两种疾病的分子机制密切相关,可能存在共同调控的靶点,因此这些靶点可能成为药物同时干预两种疾病的治疗靶点。     

The impact of the M2 internal tide on data-assimilative model estimates of the surface tide

We use a synthetic data experiment to assess the accuracy of ocean tides estimated from satellite altimetry data, with emphasis on the impact of the phase-locked internal tide, which has a surface expression of several centimeters near its sites of genesis. Previous tidal estimates have regarded this signal as a random measurement error; however, it is deterministic and not scale-separated from the barotropic (surface) tide around complex bathymetric features. The synthetic data experiments show that the internal tide has a negligible impact on the barotropic tidal fields inferred under these circumstances, and the barotropic dissipation (a quadratic functional of the tidal fields) is in good agreement with the energetics of the three-dimensional regional primitive equations model which is the source of the synthetic data.     

Seasonal variations in river discharge and nutrient export to a Northeastern Pacific estuary

Seasonal variations in dissolved nitrogen and silica loadings were related to seasonal variability in river discharge. Dissolved nutrient concentrations measured weekly at three stations in the Yaquina River, Oregon from 1999 through 2001, and then monthly in 2002 were used as the basis for developing a nutrient loading regression as part of a larger agency program for evaluating nutrient processes. Because realistic models of nutrient transport require dense data sets to capture both long and short term fluctuations in nutrient concentrations, data at one freshwater station also were collected hourly for the same years using an in-stream monitor.The effects of storm events on dissolved nutrient transport were examined during three storms, including one in a high rainfall-discharge year, and two in average years, one of which followed a drought year. During the drought year (WY2001), total dissolved nitrate input was considerably less than in wetter years. Dissolved nitrate concentrations, however, were unusually high in the first winter storm runoff after the drought. The freshwater dissolved nitrate nitrogen loads varied from 40,380 kg day⁻¹ during a high-flow storm event to 0.11 kg day⁻¹ during late summer, low flow conditions. Dissolved silica dynamics differed from those of nitrate because during storm events, silica concentrations in the Yaquina River decreased to near zero at the storm height, probably due to dilution by near surface or overland flow, and later recovered.During the time interval studied, over 94% of the dissolved nitrate and silica were transported from the watershed during the winter months of greater rainfall, indicating that seasonality and river flow are primary factors when considering nutrient loadings from this watershed system.     

Outflow of the Intermediate Oyashio Water from Sagami Bay to the Shikoku Basin

Since the Intermediate Oyashio Water (IOW) gradually accumulates in Sagami Bay, it can reasonably be supposed that the IOW also flows out from Sagami Bay, even though it may be altered by mixing with other waters. We have occasionally observed a water less than 34.2 psu with a potential density of 26.8 at the southeastern area off Izu Peninsula in July 1993 by the training vessel Seisui-maru of Mie University. Observational data supplied by the Japan Meteorological Agency and the Kanagawa Prefectural Fisheries Experimental Station show that the IOW of less than 34.1 psu was observed at northern stations of the line PT (KJ) off the Boso Peninsula and to the east of Oshima in the late spring 1993. Based upon these observations, it is concluded that the IOW flows out from Sagami Bay into the Shikoku Basin along southeastern area off the Izu Peninsula. The less saline water (<34.2 psu) was also observed to the west of Miyake-jima during the same cruise, and the westward intrusion of IOW from south of the Boso Peninsula to the Shikoku Basin through the gate area of the Kuroshio path over the Izu Ridge was detected. This event indicated that the IOW branched south of the Boso Peninsula and flowed into Sagami Bay and/or into the gate area over the Izu Ridge. The southward intrusion of IOW into the south of the Boso Peninsula is discussed in relation to the latitudinal location of the main axes of the Kuroshio and the Oyashio. This revised version was published online in July 2006 with corrections to the Cover Date.     

Study on the characteristics of the marine boundary layer in the Equatorial Pacific

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Numerical study of the meridional overturning circulation with “mixing hotspots” in the Pacific Ocean

Using an idealized ocean general circulation model, we examine the effect of “mixing hotspots” (localized regions of intense diapycnal mixing) predicted based on internal wave-wave interaction theory (Hibiya et al., 2006) on the meridional overturning circulation of the Pacific Ocean. Although the assumed diapycnal diffusivity in the mixing hotspots is a little larger than the predicted value, the upwelling in the mixing hotspots is not sufficient to balance the deep-water production; out of 17 Sv of the downwelled water along the southern boundary, only 9.2 Sv is found to upwell in the mixing hotspots. The imbalance as much as 7.8 Sv is compensated by entrainment into the surface mixed layer in the vicinity of the downwelling region. As a result, the northward transport of the deep water crossing the equator is limited to 5.5 Sv, much less than estimated from previous current meter moorings and hydrographic surveys. One plausible explanation for this is that the magnitude of the meridional overturning circulation of the Pacific Ocean has been overestimated by these observations. We raise doubts about the validity of the previous ocean general circulation models where diapycnal diffusivity is assigned ad hoc to attain the current magnitude suggested from current meter moorings and hydrographic surveys.     

南海西沙西南海域表层沉积物特征

西沙西南海域表层沉积物样品矿物成分，地球化学，微体古生物分析测试结果表明：沉积物可分为７种类型，沉积环境主要是陆坡，部分为深海平原，海洋生物，海洋化学以及火山物质的沉积起到了积极的作用，陆源物质的影响较小，它们主要来源于北部大陆和南部岛礁等物源区。