Smeared crack approach: back to the original track

This paper briefly reviews the formulations used over the last 40 years for the solution of problems involving tensile cracking, with both the discrete and the smeared crack approaches. The paper focuses on the smeared approach, identifying as its main drawbacks the observed mesh‐size and mesh‐bias spurious dependence when the method is applied ‘straightly’. A simple isotropic local damage constitutive model is considered, and the (exponential) softening modulus is regularized according to the material fracture energy and the element size. The continuum and discrete mechanical problems corresponding to both the weak discontinuity (smeared cracks) and the strong discontinuity (discrete cracks) approaches are analysed and the question of propagation of the strain localization band (crack) is identified as the main difficulty to be overcome in the numerical procedure. A tracking technique is used to ensure stability of the solution, attaining the necessary convergence properties of the corresponding discrete finite element formulation. Numerical examples show that the formulation derived is stable and remarkably robust. As a consequence, the results obtained do not suffer from spurious mesh‐size or mesh‐bias dependence, comparing very favourably with those obtained with other fracture and continuum mechanics approaches. Copyright © 2006 John Wiley & Sons, Ltd.     

基于网络药理学探究补阳还五汤治疗颈椎病的作用机制

目的：基于网络药理学与分子对接技术分析补阳还五汤治疗颈椎病的作用机制。方法：使用TCMSP、化学专业数据库获取补阳还五汤的活性成分,并对潜在靶点进行预测及规范。分别从PharmGKB、DisGeNET、OMIM、GeneCards数据库中得到颈椎病疾病靶点,利用韦恩图获取补阳还五汤与颈椎病的交集靶点。通过CytoScape软件构建中药-活性成分-疾病靶点和蛋白质-蛋白质相互作用（PPI）网络,获得核心有效成分与关键靶点,利用David数据库对潜在靶点进行富集分析。最后运用AutoDock Vina软件对补阳还五汤核心有效成分与关键靶点进行分子对接验证。结果：共获得补阳还五汤治疗颈椎病的有效活性成分97个,包括槲皮素、山柰酚、黄芩素、木犀草素等;交集靶点64个,关键靶点有白细胞介素-6（IL-6）、肿瘤坏死因子（TNF）、丝氨酸/苏氨酸蛋白激酶1（AKT1）、白细胞介素-1B（IL-1B）等;主要涉及肿瘤坏死因子（TNF）、白细胞介素-17（IL-17）、磷脂酰肌醇3-激酶（PI3K）/蛋白激酶B（Akt）等信号通路,分子对接结果显示核心有效成分与关键靶点之间结合紧密,为补阳还五汤治疗颈椎病提供相应条件。结论：该研究在总体上预测了补阳还五汤治疗颈椎病的活性成分、靶点和信号通路,作用途径广泛,为下一步的临床应用提供参考及思路。     

基于网络药理学与分子对接技术探讨青蛇方外用治疗湿疹的作用机制

目的：基于网络药理学与分子对接技术探讨青蛇方外用治疗湿疹的作用机制。方法：应用TCMSP和UniProt数据库平台查询青蛇方组方的有效活性成分及靶基因,与疾病靶基因取交集后构建蛋白质-蛋白质相互作用(PPI)网络;应用DAVID数据库,对潜在核心作用靶点基因进行基因本体（GO）功能、京都基因与基因组百科全书（KEGG）通路富集分析。利用分子对接原理论证青蛇方生物活性成分与核心靶点的分子结合能力。结果：筛选出青蛇方有效成分63种,作用靶点99个;主要有β-谷甾醇、2,4,7-三羟基-9,10-二氢菲、靛蓝素、豆甾醇、色氨酸等关键成分;转录因子AP-1（JUN）、肿瘤坏死因子（TNF）、原癌基因（RELA）、干扰素γ（IFNG）、转化生长因子-β1（TGF-β1）等核心基因。关键信号通路有癌症信号通路、恰加斯病通路、弓形体病通路、脂质和动脉粥样硬化通路等,分子对接结果显示活性成分与核心靶点基因结合能力较强。结论：青蛇方外用可以通过多种活性成分、多种通路有效抑制免疫炎症反应,促进免疫系统正常运行,从而达到治疗湿疹的目的。     

山西沁水盆地煤层气成藏的微观动力能条件研究

煤层气成藏的微观动力能条件主要包括煤储层的孔隙—裂隙系统、煤储层的生气作用和储气作用两个方面。以山西沁水盆地为例,深入剖析了煤储层的孔隙—裂隙系统及其发育历程、煤储层的生气作用与能量聚散,阐明了煤层气成藏的微观动力能对成藏效应的控制作用。结果表明:构造作用对储层渗透率具有明显的控制作用,成烃增压致使能量聚集,成为盖层突破作用的主要驱动力,而能量放散则主要是通过煤储层孔隙—裂隙系统的产生、发展。根据上述研究成果,沁水盆地煤层气成藏的地质区划结果为:盆地南部的有利区带为阳城和晋城的北部地区,包括潘庄、樊庄、郑庄等地区;盆地中部的有利区带为安泽—沁源地区,位于盆地西斜坡的中南部;盆地北部的可能有利区带为寿阳东南部地区,位于榆次东北部和阳泉西南部之间。     

西南某电站右岸倾坡内夹泥裂隙成因探讨

西南某拟建大型水电站的右岸岩体中存在倾向坡内的夹泥裂隙，通过对其的发育情况以及所处的地质环境进行系统的研究和认真剖析，认为该区内的倾坡内夹泥裂隙的成因并非正常卸荷引起，而是在构造的基础上，穹隆挽近期隆起的结果，为右岸坝肩稳定性评价提供了可靠的依据。     

结构设计地震作用效应影响因素及规律分析

基于现行《建筑抗震设计规范》（GB50011－2001），本文分析了现行抗震设计中影响结构设计地震作用效应的主要因素，以规则平面框架对例对新旧规范影响结构设计地震作用效应的因素进行了对比，给出了其间的重要变化和基本规律。     

Erosion rates of alpine bedrock summit surfaces deduced from in situ Be and Al

We have measured the concentration of in situ produced cosmogenic ¹⁰Be and ²⁶Al from bare bedrock surfaces on summit flats in four western U.S. mountain ranges. The maximum mean bare-bedrock erosion rate from these alpine environments is 7.6 ± 3.9 m My⁻¹. Individual measurements vary between 2 and 19 m My⁻¹. These erosion rates are similar to previous cosmogenic radionuclide (CRN) erosion rates measured in other environments, except for those from extremely arid regions. This indicates that bare bedrock is not weathered into transportable material more rapidly in alpine environments than in other environments, even though frost weathering should be intense in these areas. Our CRN-deduced point measurements of bedrock erosion are slower than typical basin-averaged denudation rates ( 50 m My⁻¹). If our measured CRN erosion rates are accurate indicators of the rate at which summit flats are lowered by erosion, then relief in the mountain ranges examined here is probably increasing.

We develop a model of outcrop erosion to investigate the magnitude of errors associated with applying the steady-state erosion model to episodically eroding outcrops. Our simulations show that interpreting measurements with the steady-state erosion model can yield erosion rates which are either greater or less than the actual long-term mean erosion rate. While errors resulting from episodic erosion are potentially greater than both measurement and production rate errors for single samples, the mean value of many steady-state erosion rate measurements provides a much better estimate of the long-term erosion rate.     

类石材料--灰泥的冻融过程

Serious failure on the slope of rock ground can be caused by a cyclic action of freezing and thawing in the cold regions. The frost susceptibility and the effect of freezing and thawing onthe rock material, however, have not been well investigated. In order to find out the freezing effect on the rock materials, mortar specimens are frozen as a pseudo-rock material under the constant rate of freezing by means of controlling the temperature of both ends of specimen. The freezing process is given one-dimensionally to the cylindrical samples in the laboratory to simulate the in-situ freezing phenomena in the natural ground. Formation of ice lens, frost heave and water intake during freezing process are observed on the mortar specimen under constant freezing rate, which probably causes cracks or large deformation in the real rock ground. The values of the velocity of elastic wave propagation are compared before and after freezing process to estimate the degree of weathering due to freezing and thawing.     

Preferential embrittlement of graphitic schists during extensional unroofing in the Alps: the effect of fluid composition on rheology in low-permeability rocks

Interlayered graphitic and non‐graphitic schists from the Tauern Window, Eastern Alps, record contrasting mechanical behaviour during extensional exhumation. Graphitic schists contain mesoscale extension fractures, pervasive microcracks in garnet, and abundant secondary fluid inclusion planes; all three types of structures are oriented perpendicular to the stretching lineation. Crack spacings in garnet from graphitic samples are tightly clustered around a mean of 180 μm. Non‐graphitic schists have fewer and more randomly oriented microcracks and fluid inclusion planes and maintained strain compatibility via crystal plasticity. The presence or absence of graphite appears to have exerted a fundamental control on rheology during unroofing. Calculations for a model graphitic rock at 500 °C and f_O2 = 10^?24 MPa show that the equilibrium metamorphic fluid evolves from X_CO2 = 0.07 to 0.38 during decompression from 700 to 400 MPa, in agreement with microcrack fluid inclusion data that show a change from X_CO2 < 0.1 to 0.45 in graphitic samples over the same pressure interval. This compositional shift results in >60% expansion of the pore fluid during decompression. H₂O‐rich fluid in non‐graphitic rocks expands <15% over the same pressure interval. The greater pore fluid expansion in low‐permeability graphitic horizons likely promoted tensile failure during unroofing. These results suggest that microcracking should be an inevitable consequence of decompression in many graphitic schists, whereas rocks that lack graphite are less likely to undergo microcracking. Microseismicity is predicted to be more common in graphitic than non‐graphitic rocks during unroofing of mountain belts.     

地幔柱构造研究概述

地幔柱构造理论是近年来构造地质学研究的新热点,是当今地球科学——地质学、构造学、矿床学、地球物理学、生物学、环境学和气象学等许多学科关注和研究的前沿领域。它的形成和演化及动力学观点被称为继大陆漂移和板块构造后的第3次地学浪潮,引起了中外地学者的高度重视。本文对地幔柱构造研究现状作了概略介绍,以期在铀矿地质领域内引起关注．起到传递信息和抛砖引玉的作用。