基于生物信息学探讨骨质疏松症与2型糖尿病的关系

目的：基于生物信息学探讨骨质疏松症与 2 型糖尿病的关系。方法：通过基因表达汇编（GEO）数据库检索骨质疏松症和2型糖尿病的相关数据集,并筛选骨质疏松症-2型糖尿病共同差异表达基因,将数据导入STRING数据库找寻关键基因,以一个单细胞测序数据集作为检验集验证关键基因细胞层面的表达水平,对筛选结果进行基因本体（GO）功能及京都基因与基因组百科全书（KEGG）通路富集分析,并对关键靶点、相关中药进行频数统计及功效分类。结果：骨质疏松症与 2 型糖尿病相关通路集中在 ErbB信号通路、丝活化蛋白激酶（MAPK）信号通路、神经营养素信号通路、NOD样受体信号通路。频数统计结果显示,与骨质疏松症-2型糖尿病关键基因相关的中药有51味,以功效分类,可分为清热解毒药、止痛药、祛风药、补虚药、止呕药。结论：骨质疏松症和2型糖尿病都是复杂的代谢性疾病,涉及众多基因表达网络和信号通路。尽管两种疾病存在复杂的基因网络背景,但是分析结果表明两种疾病之间仍存在高度重合的差异基因表达和信号通路。这表明两种疾病的分子机制密切相关,可能存在共同调控的靶点,因此这些靶点可能成为药物同时干预两种疾病的治疗靶点。     

南海北部主要经济鱼类体长与体重关系

文中根据1997～1999年和2001～2002年期间在南海北部底拖网调查的43种共33 389尾鱼的体长（叉长、肛长）和体重数据,应用统计分析方法对各鱼种体长与体重关系进行分析.结果表明,43种鱼分别隶属于4目16科25属,相关系数R^2的范围为0.764～0.993,相关系数R^2值相对较高,其中58%的R^2值超过0.95.幂指数b值范围为2.50～3.44,平均2.90.盒须图分析表明,50%的b值在2.79～3.01范围.经初步分析,43种主要经济鱼类中,有16种为等速生长、22种负的异速生长和5种正的异速生长.     

Study on copper complexing ligand concentrations in several China’s coastal waters

Copper complexing ligand concentrations in the Daya Bay, Qingdao coast, Jiaozhou Bay, South China Sea and Huanghe Estuary waters were determined by the anodic stripping voltammetry technique. The distribution regularity and the relationship with other parameters were discussed. The results were as follows: Copper complexing ligand concentrations of the South China Sea were a little higher than those of other sea areas, and they were apparently higher than those of the ocean. Compared with the subsurface layer (SSL) in the sea surface microlayer copper complexing ligand concentrations showed an enrichment phenomenon, of which the mechanism is similar to dissolved organic matter. The metal complexing ligand concentration profiles of the South China Sea showed that the value in the sea surface was the highest, then it decreased with depth accruing, and a higher value appeared at the bottom. Copper complexing ligand concentrations were higher than those of cadmium and lead. Ligands in each sea area exhibited a complicated property. In short, the distribution regularity of copper complexing ligand concentrations in China' s coastal waters was consistent with that of other regions in the world. Meanwhile, the positive relationship between the copper complexing ligand concentrations and biological oxygen demand, chemical oxygen demand, dissolved organic carbon, and viscosity were found clearly.     

利用归一化层速度预测和研究储层物性的方法

归一化层速度是对任意深度处的层速度进行归一化处理的一种速度形式，归一化处理的目的是把任意深度处的层速度转换为与深度无关的格式，归一化后层速度的横向变化主要取决于地层岩性，孔隙度等物性的变化，利用这一特点可以方便地利用已知钻井资料对其进行标定，比较简单地进行地层岩性，孔隙度等特性的预测。实际应用表明，其预测结果与钻井揭示吻合较好，预测效果令人满意。     

对虾封闭式工厂化养殖水环境要素的变化特征及其相互关系

根据2002年8月7～8日对虾工厂化养成中后期A、B代表池的实测数据，分析讨论了该时期养殖水体中环境要素的变化特征及其相互关系．结果表明：研究水体水温、盐度和溶解氧含量适宜．日变化幅度不大．但pH值略为偏低，而COD值明显偏高．与该时期投饵量大，残饵及排泄物明显增加有关．但对A池来说，生物作用的影响占主导地位，而对B池而言．则以化学过程影响为主．     

中国西部地区基于经验模型的土壤水分反演

地表土壤水分含量的时空分布信息是十分重要的,常常作为水文模型、气候模型、生态模型的输入参数,同时,也是干旱预报、农作物估产等工作的重要指标。被动微波遥感是监测土壤含水量最有效的手段之一。相比红外与可见光,它具有波长长,穿透能力强的优势。相比主动微波雷达,被动微波辐射计具有监测面积大、周期短,受粗糙度影响小,对土壤水分更为敏感,算法更为成熟的优势。目前,已研究出许多反演土壤水分的方法.本课题的主要内容是借助AMSR-E土壤水分影像数据、MODIS归一化植被指数(NDVI)影像数据和MODIS分类影像数据,利用ENVI软件进行遥感图像数据处理,运用统计分析方法建立NDVI与土壤水分的经验模型,研究中国西部地区稀疏植被覆盖区土壤水分的反演。     

基于MODIS数据的雪面温度遥感反演(英文)

On the basis of simplification of the Planck function in a low temperature range, this paper revises the practical split-window algorithm and presents a method for retrieving snow surface temperature （Ts） based on MODIS data in the middle-latitude region. The application of this method in Qinghai Lake region reveals that it is feasible for the retrieval of Ts. Results of correlation analysis indicate that there was strong negative relationship between Ts and altitude. By analyzing three typical areas in which land cover was relatively homogenous, this paper discusses the relationship between Ts and normalized difference snow index （NDSI） and then presents a new concept named ＂NDSI-Ts space＂.