A high resolution,multiproxy Late‐glacial record of climate change and intrasystem responses in northwest England

A lacustrine carbonate sequence from Hawes Water, Lancashire, UK, has been studied using stable isotopic, lithological, pollen and mineral magnetic analysis. The data reveal four abrupt climatic oscillations in the Late‐glacial Interstadial leading up to the onset of the Loch Lomond Stadial. The data also point to climatic warming relatively early within the stadial, ca. 12 500 GRIP yr, prior to the onset of the Holocene. The oxygen isotope record is taken as a signature of climate forcing against which the response of the lake‐system can be monitored. By adopting this approach it is revealed that the response of the biological system to the rapid climatic oscillations is non‐linear and primarily a function of the antecedent conditions. A significant end‐Devensian isotopic excursion (A) is matched by only minor changes in the cold‐adapted floras and faunas. During the warmer interstadial, the response of the biological ecosystem (events B–D) is clearly influenced by thresholds: major changes in the catchment vegetation associated with relatively minor oscillations in the isotopic signature. The stratigraphical patterns reveal significant lag effects between the onset of climate deterioration and resulting changes in vegetation. Copyright © 2002 John Wiley & Sons, Ltd.     

基于生物信息学探讨骨质疏松症与2型糖尿病的关系

目的：基于生物信息学探讨骨质疏松症与 2 型糖尿病的关系。方法：通过基因表达汇编（GEO）数据库检索骨质疏松症和2型糖尿病的相关数据集,并筛选骨质疏松症-2型糖尿病共同差异表达基因,将数据导入STRING数据库找寻关键基因,以一个单细胞测序数据集作为检验集验证关键基因细胞层面的表达水平,对筛选结果进行基因本体（GO）功能及京都基因与基因组百科全书（KEGG）通路富集分析,并对关键靶点、相关中药进行频数统计及功效分类。结果：骨质疏松症与 2 型糖尿病相关通路集中在 ErbB信号通路、丝活化蛋白激酶（MAPK）信号通路、神经营养素信号通路、NOD样受体信号通路。频数统计结果显示,与骨质疏松症-2型糖尿病关键基因相关的中药有51味,以功效分类,可分为清热解毒药、止痛药、祛风药、补虚药、止呕药。结论：骨质疏松症和2型糖尿病都是复杂的代谢性疾病,涉及众多基因表达网络和信号通路。尽管两种疾病存在复杂的基因网络背景,但是分析结果表明两种疾病之间仍存在高度重合的差异基因表达和信号通路。这表明两种疾病的分子机制密切相关,可能存在共同调控的靶点,因此这些靶点可能成为药物同时干预两种疾病的治疗靶点。     

海上矿石运输最优船队的组建

针对海上矿石运输，介绍了一种完成定量任务并能使投资费用最少为目标的最优船队组建方法，同时对易变参数进行了灵敏度分析，使决策更加科学化     

基于坐标归一化和奇异值分解的直接线性变换解法

直接线性变换方法是数字摄影测量和计算机视觉领域最常用的解析处理方法之一,特别适用于未检校数码相机的三维测量,但直接线性参数间的相关性、物方控制的约束和设计矩阵元素数量级的较大差异,均可导致法矩阵严重病态,从而影响解的稳定性。本文借鉴改进的八点基本矩阵估计算法,采用基于坐标归一化和奇异值分解的解法,即首先将像点和物点坐标进行相似变换得到归一化坐标后组成法矩阵,其次利用矩阵奇异值分解方法代替常规的最小二乘方法,模拟和真实数据表明,此方法可以有效提高解算精度和稳定性。     

Association between multi-level inorganic arsenic exposure from drinking water and skin lesions in Inner Mongolia, China

Arsenic is one of the most important single-substance toxicants in the environment. In Inner Mongolia of China, 300000 residents are believed to drink water containing 〉50 μg/L. Skin lesions have been known as the most common consequences resulting from chronic exposure to arsenic. To clarify the prevalence of arsenic-induced skin lesions, it is important to assess the impact of this problem on the target population, and to make future planning. We evaluated the association between multi-level inorganic arsenic exposure from drinking water and skin lesions in an arsenic-affected area in Inner Mongolia, China. 109 and 32 subjects fi＇om high-level arsenic-affected （〉5 μg/L） village and low-level （≤50 μg/L） village were recruited and had detailed physical examination with special emphasis on arsenic-related skin lesions. Arsenic exposure was measured for each participant with As concentration of primary well and the duration of using the well was recorded. Arsenic-induced skin lesions including keratosis, pigmentation, and/or leucomelanosis were diagnosed in 56 and 3 subjects in the two villages, respectively. Logistic regression was conducted to calculate prevalence-odd ratios of skin lesions by levels of arsenic exposure with adjustment of sex, age group, smoking and duration of exposure. A consistent dose-response relationship between arsenic exposure level and skin lesion risk was observed.     

地缘经济关系测度与分析的理论方法探讨--以云南省为例

文章首先简要分析了地缘经济学的发展进程和研究内容，提出以保护国家利益增强综合国力为主要研究目的的地缘经济理论在一定程度上可以指导不同级别区域经济合作策略的制定。然后在探究了地缘经济关系涵义的前提下，设计了地缘经济关系的测度体系，并用该方法对云南省地缘经济关系进行了数量测度和类型判别，进而对该省地缘经济关系进行了分析和评价，对经济发展提出了建议。     

保持主分量变换结果信息的量化方法

从主分量变换后图像信息保持的角度出发，充分分析了变换结果存储导致信息丢失的原因；同时以直接线性变换为基础，提出了另外两种新的对主分量变换结果进行量化的方法；并对这3种方法进行了充分的比较，文中最后以信息熵为指标评价了3种方法的优劣。